Gene: RARRES2

5919
HP10433|TIG2
retinoic acid receptor responder 2
protein-coding
7q36.1
Ensembl:ENSG00000106538 MIM:601973 Vega:OTTHUMG00000158325 UniprotKB:Q99969
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.027e-1 (AD)  1.096e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11327659chr7:150037044RARRES24.800e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSC22D40.835
DDAH20.826
ECI10.821
EIF4EBP30.82
TAX1BP30.818
BCL7C0.812
SIGIRR0.811
METRN0.804
FAM181B0.799
EFEMP20.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1QL3-0.553
SCN8A-0.543
MCHR2-0.543
GRM5-0.538
KCNH1-0.537
GRIN2A-0.533
PPM1E-0.533
MTUS2-0.531
GABRG3-0.526
PCDHAC2-0.526

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RARRES2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of RARRES2 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RARRES2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RARRES2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RARRES2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RARRES2 mRNA19770486
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of RARRES2 mRNA22948218
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of RARRES2 protein23254195
D013196DihydrotestosteroneRARRES2 protein promotes the reaction [Dihydrotestosterone results in decreased abundance of Estradiol]22948218
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Particulate Matter] results in increased expression of RARRES2 protein"26773141
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Vehicle Emissions] results in increased expression of RARRES2 protein"26773141
C547126AZM551248AZM551248 results in increased expression of RARRES2 mRNA22323515
C487081belinostatbelinostat results in increased expression of RARRES2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RARRES2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RARRES2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RARRES2 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RARRES2 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RARRES2 mRNA]25566086
D004958EstradiolEstradiol results in decreased expression of RARRES2 mRNA23019147
D004958EstradiolRARRES2 protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]22948218
D004958EstradiolRARRES2 protein promotes the reaction [Dihydrotestosterone results in decreased abundance of Estradiol]22948218
D004958EstradiolRARRES2 protein results in decreased abundance of Estradiol22948218
C006780bisphenol Abisphenol A results in increased expression of RARRES2 mRNA25181051
D001786Blood GlucoseRARRES2 protein affects the abundance of Blood Glucose22355640
D001786Blood GlucoseRARRES2 protein affects the reaction [Blood Glucose affects the secretion of INS1 protein]22355640
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RARRES2 mRNA22079614
D002211CapsaicinRARRES2 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]20383154
D002220CarbamazepineCarbamazepine affects the expression of RARRES2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RARRES2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of RARRES2 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of RARRES2 mRNA23650126
D005576ColforsinRARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]22948218
D005576ColforsinRARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein]22948218
D019327Copper SulfateCopper Sulfate results in decreased expression of RARRES2 mRNA19549813
D003513CycloheximideCycloheximide results in increased expression of RARRES2 mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RARRES2 mRNA19684285
D016572CyclosporineCyclosporine results in decreased expression of RARRES2 mRNA20106945|2163298
D003907DexamethasoneDexamethasone results in decreased expression of RARRES2 mRNA25047013
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of RARRES2 mRNA23428407
D004041Dietary FatsDietary Fats results in decreased expression of RARRES2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of RARRES2 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of RARRES2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of RARRES2 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of RARRES2 mRNA19638242
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of RARRES2 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RARRES2 mRNA"19480007
D004237DiuronDiuron results in decreased expression of RARRES2 mRNA25152437
C118739entinostatentinostat results in increased expression of RARRES2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RARRES2 mRNA17557909
C024565ethylene dichlorideethylene dichloride results in decreased expression of RARRES2 mRNA28189721
D005472FluorouracilFluorouracil results in decreased expression of RARRES2 mRNA16709241
D005485FlutamideFlutamide results in increased expression of RARRES2 mRNA24793618
C576694GKT137831GKT137831 inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]25617244
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to RARRES2 gene]20091679
C412815GW 4064GW 4064 results in increased expression of RARRES2 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of RARRES2 mRNA28973697
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of RARRES2 mRNA23428407
C410337K 7174K 7174 results in decreased expression of RARRES2 mRNA24086573
C005219methyl cellosolvemethyl cellosolve results in decreased expression of RARRES2 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RARRES2 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RARRES2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RARRES2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of RARRES2 mRNA24136188
D009532NickelNickel results in decreased expression of RARRES2 mRNA25583101
C520337NSC 74859NSC 74859 inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]25617244
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RARRES2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of RARRES2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of RARRES2 mRNA20880076
D000073878Palm OilPalm Oil results in decreased expression of RARRES2 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RARRES2 mRNA26272509
D052638Particulate Matter"[Antigens, Dermatophagoides co-treated with Particulate Matter] results in increased expression of RARRES2 protein"26773141
D052638Particulate MatterParticulate Matter results in increased expression of RARRES2 protein26773141
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of RARRES2 mRNA23602845
D010795Phthalic AcidsPhthalic Acids results in decreased expression of RARRES2 mRNA21061450
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of RARRES2 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of RARRES2 mRNA18037150
D011374ProgesteroneRARRES2 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]22948218
D011441PropylthiouracilPropylthiouracil results in decreased expression of RARRES2 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of RARRES2 mRNA25626140
D011794QuercetinQuercetin results in increased expression of RARRES2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RARRES2 mRNA25895662
D012834SilverSilver results in increased expression of RARRES2 mRNA27131904
D012999SomanSoman results in decreased expression of RARRES2 mRNA19281266
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RARRES2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RARRES2 mRNA19684285|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RARRES2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RARRES2 mRNA18465118|2121527
C009495titanium dioxidetitanium dioxide affects the expression of RARRES2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RARRES2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of RARRES2 mRNA25729387
C483909torcetrapibGKT137831 inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]25617244
C483909torcetrapibNSC 74859 inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]25617244
C483909torcetrapibtorcetrapib results in increased expression of RARRES2 mRNA25617244
D014212TretinoinTretinoin results in decreased expression of RARRES2 mRNA23724009
C011559tributyltintributyltin results in increased expression of RARRES2 mRNA23428407
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RARRES2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of RARRES2 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of RARRES2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARRES2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of RARRES2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of RARRES2 mRNA24383497|2627250
D014640VancomycinVancomycin results in decreased expression of RARRES2 mRNA18930951
D001335Vehicle Emissions"[Antigens, Dermatophagoides co-treated with Vehicle Emissions] results in increased expression of RARRES2 protein"26773141
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RARRES2 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of RARRES2 protein26773141
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of RARRES2 mRNA19165385
C029297vinylidene chloridevinylidene chloride results in increased expression of RARRES2 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of RARRES2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-IPI14530373  
GO:0005515protein binding-IPI14530373  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-IDA9204961  
GO:0001701in utero embryonic development-IEP19443732  
GO:0001934positive regulation of protein phosphorylation-IDA17635925  
GO:0002576platelet degranulation-TAS-  
GO:0006935chemotaxis-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0010759positive regulation of macrophage chemotaxis-IMP19443732  
GO:0019732antifungal humoral response-IMP23527010  
GO:0030154cell differentiation-IEA-  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-IMP23527010  
GO:0045600positive regulation of fat cell differentiation-ISS-  
GO:0048566embryonic digestive tract development-IMP19443732  
GO:0050829defense response to Gram-negative bacterium-IMP23527010  
GO:0050830defense response to Gram-positive bacterium-IMP23527010  
GO:0050921positive regulation of chemotaxis-IBA21873635  
GO:0050921positive regulation of chemotaxis-ISS-  
GO:0050994regulation of lipid catabolic process-IBA21873635  
GO:0050994regulation of lipid catabolic process-ISS-  
GO:0061760antifungal innate immune response-IMP23527010  
GO:2001275positive regulation of glucose import in response to insulin stimulus-IBA21873635  
GO:2001275positive regulation of glucose import in response to insulin stimulus-IDA18242188  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-ISS-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA23527010  
GO:0031012extracellular matrix-IBA21873635  
GO:0031012extracellular matrix-IDA19443732  
GO:0031089platelet dense granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27446956Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese. (2016)Huang HWBiomed Res Int