Gene: RARRES3

5920
HRASLS4|HRSL4|PLA1/2-3|RIG1|TIG3
retinoic acid receptor responder 3
protein-coding
11q12.3
Ensembl:ENSG00000133321 MIM:605092 Vega:OTTHUMG00000167850 UniprotKB:Q9UL19
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.837e-1 (AD)  4.156e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMB80.89
AGTRAP0.877
IGFLR10.873
PSMB90.865
IFI350.861
IFITM30.859
C1R0.859
VAMP50.852
NPC20.843
SERPING10.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA1D-0.611
ABCC12-0.598
MARCH4-0.596
PPEF1-0.579
F7-0.573
SLC7A4-0.571
GPR61-0.571
XKR4-0.562
NEUROD6-0.562
TPBGL-0.556

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of RARRES3 mRNA19041380
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of RARRES3 mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of RARRES3 mRNA17034753
D000082AcetaminophenAcetaminophen results in decreased expression of RARRES3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RARRES3 protein20106945
C103303alitretinoinalitretinoin results in increased expression of RARRES3 mRNA17034753
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RARRES3 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RARRES3 mRNA24449571
C004984apocarotenalapocarotenal results in decreased expression of RARRES3 mRNA17034753
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RARRES3 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of RARRES3 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of RARRES3 mRNA22576693|2768578
C006780bisphenol Abisphenol A results in increased expression of RARRES3 mRNA24586524
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARRES3 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of RARRES3 mRNA26191083
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNA12634122
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNA12634122
D016572CyclosporineCyclosporine results in increased expression of RARRES3 mRNA20106945
C014347decitabinedecitabine affects the expression of RARRES3 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of RARRES3 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARRES3 mRNA28628672
D002945CisplatinCisplatin affects the expression of RARRES3 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RARRES3 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of RARRES3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of RARRES3 mRNA21592394
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of RARRES3 mRNA"23811387
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RARRES3 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of RARRES3 mRNA23649840
D019833GenisteinGenistein results in increased expression of RARRES3 mRNA15256057
C492448ICG 001ICG 001 results in increased expression of RARRES3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARRES3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARRES3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RARRES3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RARRES3 mRNA23086925
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNA12634122
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of RARRES3 mRNA12634122
D009151Mustard GasMustard Gas results in increased expression of RARRES3 mRNA25102026
D009285NaphthoquinonesNaphthoquinones results in increased expression of RARRES3 mRNA23811387
D009532NickelNickel results in increased expression of RARRES3 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of RARRES3 mRNA22714537
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of RARRES3 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RARRES3 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of RARRES3 mRNA12727804
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RARRES3 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of RARRES3 mRNA12634122|1272780
C017947sodium arsenitesodium arsenite results in increased expression of RARRES3 mRNA22714537
C061133tamibarotenetamibarotene results in increased expression of RARRES3 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of RARRES3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of RARRES3 mRNA21592394
D014212TretinoinTretinoin results in increased expression of RARRES3 mRNA15498508|1605412
D014635Valproic AcidValproic Acid results in decreased expression of RARRES3 mRNA29154799
D014801Vitamin AVitamin A results in increased expression of RARRES3 mRNA17034753
D014810Vitamin EVitamin E results in increased expression of RARRES3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004623phospholipase A2 activity-IDA20100577  
GO:0005515protein binding-IPI22908223  25416956  
GO:0016746transferase activity, transferring acyl groups-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-IDA20100577  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0016042lipid catabolic process-IEA-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26594007Differential gene expression patterns between smokers and non-smokers: cause or consequence? (2017 Mar)Vink JMAddict Biol