Gene: RASA1

5921
CM-AVM|CMAVM|GAP|PKWS|RASA|RASGAP|p120|p120GAP|p120RASGAP
RAS p21 protein activator 1
protein-coding
5q14.3
Ensembl:ENSG00000145715 MIM:139150 Vega:OTTHUMG00000162605 UniprotKB:P20936
NG_011650.1
PubMed
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.313e-2 (AD)  6.589e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3752862chr5:87338156 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAPG0.969
BCAP290.964
PIK3CB0.964
VPS350.963
WDR470.962
VPS360.961
PDS5B0.959
MTMR90.958
CAND10.957
GSK3B0.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.525
OR4F29-0.493
CSAG1-0.457
MTRNR2L10-0.419
MTRNR2L6-0.414
HEY2-0.399
AQP5-0.398
RAB13-0.398
MTRNR2L9-0.396
RNF135-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RASA1 mRNA"21394737
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the expression of RASA1 mRNA17367762
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RASA1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RASA1 mRNA"12606953
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RASA1 protein"12606953
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of RASA1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of RASA1 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of RASA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RASA1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RASA1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RASA1 mRNA21298039
D001151ArsenicArsenic results in increased methylation of RASA1 promoter21291286
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RASA1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RASA1 mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of RASA1 mRNA19264808
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RASA1 mRNA28628672
C037123cadmium sulfatecadmium sulfate results in decreased expression of RASA1 mRNA19274763
D002220CarbamazepineCarbamazepine affects the expression of RASA1 mRNA24752500
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of RASA1 mRNA18636392
C018021cobaltous chloridecobaltous chloride results in decreased expression of RASA1 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of RASA1 mRNA24690739
D003375CoumestrolCoumestrol results in decreased expression of RASA1 mRNA19167446
C402665CP 31398CP 31398 results in increased expression of RASA1 mRNA15155752
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RASA1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of RASA1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RASA1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RASA1 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of RASA1 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of RASA1 mRNA]27392435
D004008DiclofenacDiclofenac affects the expression of RASA1 mRNA24752500
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of RASA1 mRNA24690739
D004317DoxorubicinDoxorubicin affects the expression of RASA1 mRNA17367762
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of RASA1 mRNA19118595
D018120FinasterideFinasteride results in increased expression of RASA1 mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of RASA1 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of RASA1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of RASA1 mRNA24136188
D005492Folic AcidFolic Acid affects the expression of RASA1 mRNA16361273
D006160Guanosine TriphosphateKRAS protein mutant form inhibits the reaction [RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]]28154176
D006160Guanosine TriphosphateRASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]28154176
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RASA1 mRNA28628672
C051890irinotecanirinotecan analog results in decreased expression of RASA1 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RASA1 mRNA28628672
D007545IsoproterenolIsoproterenol affects the localization of RASA1 protein1382416
D007545IsoproterenolIsoproterenol results in increased expression of and results in increased phosphorylation of RASA1 protein1382416
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of RASA1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of RASA1 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of RASA1 mRNA27392435
D007649KetamineKetamine results in decreased expression of RASA1 mRNA20080153
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RASA1 mRNA"15329391
D015735MifepristoneMifepristone results in decreased expression of RASA1 mRNA19439560
D015735MifepristoneMifepristone results in increased expression of RASA1 mRNA19439560
D008942MitoxantroneRASA1 mRNA affects the susceptibility to Mitoxantrone16044152
C108709oleoyl-estroneoleoyl-estrone results in increased expression of RASA1 mRNA17725831
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RASA1 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of RASA1 mRNA18636392
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of RASA1 mRNA17616710
D010634PhenobarbitalPhenobarbital results in decreased expression of RASA1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of RASA1 mRNA18445702
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RASA1 mRNA22714537
D011794QuercetinQuercetin results in decreased expression of RASA1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of RASA1 mRNA15576828
C116926rofecoxibrofecoxib affects the expression of RASA1 mRNA17070997
C017947sodium arsenitesodium arsenite results in increased expression of RASA1 mRNA12016162
D012969Sodium FluorideSodium Fluoride results in decreased expression of RASA1 mRNA27862939
D013467SulindacSulindac results in decreased expression of RASA1 mRNA24136188
D013629TamoxifenTamoxifen affects the expression of RASA1 mRNA14699072
C003377taxifolintaxifolin results in decreased expression of RASA1 mRNA17541156
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RASA1 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RASA1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RASA1 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of RASA1 mRNA17367762
D014635Valproic AcidValproic Acid affects the expression of RASA1 mRNA25979313
D014638VanadatesVanadates results in increased expression of RASA1 mRNA22714537
C025643vinclozolinvinclozolin affects the expression of RASA1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0003924GTPase activity-TAS-  
GO:0005096GTPase activator activity-EXP7478585  
GO:0005102signaling receptor binding-IPI2157284  2176151  
GO:0005515protein binding-IPI1314164  1375321  1689011  8382774  8618896  8649363  
9219684  15077193  15504032  15574420  16273093  18761085  
19151751  20598684  20808760  21664272  24412244  24728074  
GO:0019870potassium channel inhibitor activity-NAS1553544  
GO:0051020GTPase binding-IPI2122974  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0000281mitotic cytokinesis-ISS-  
GO:0001570vasculogenesis-ISS-  
GO:0001953negative regulation of cell-matrix adhesion-IDA8344248  
GO:0007162negative regulation of cell adhesion-IDA8344248  
GO:0007165signal transduction-IDA1756860  
GO:0008360regulation of cell shape-NAS9113414  
GO:0030833regulation of actin filament polymerization-IDA8344248  
GO:0035556intracellular signal transduction-NAS1581965  
GO:0043066negative regulation of apoptotic process-IDA15542850  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048514blood vessel morphogenesis-IMP23687085  
GO:0051252regulation of RNA metabolic process-NAS9113414  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005737cytoplasm-NAS2821624  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29127119RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition. (2018 Mar 15)Hayashi TClin Cancer Res
26834999Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence. (2015)Krishnan NF1000Res