Gene: ACE2

59272
ACEH
angiotensin I converting enzyme 2
protein-coding
Xp22.2
Ensembl:ENSG00000130234 MIM:300335 Vega:OTTHUMG00000021177 UniprotKB:Q9BYF1
NG_012575.1
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCL150.729
OR51A40.724
DAZ40.721
ALX30.706
PI150.679
DEFB4B0.661
TGIF2LY0.643
ABCA60.636
HYAL40.63
OR4K20.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOG-0.383
C15orf59-0.382
ASPDH-0.376
CPLX3-0.375
HRH3-0.361
NEUROD6-0.361
C1orf53-0.36
KCNIP3-0.36
DBNDD1-0.356
DLX1-0.355

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00691MoexiprilSmall Molecule103775-10-6ApprovedTarget
DB05203SPP1148Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein]"27428043
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACE2 mRNA"19114083
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of ACE2 mRNA"28940058
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of ACE2 mRNA25716159
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ACE2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ACE2 mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ACE2 mRNA28522335
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNA17639512
C044946benazeprilACE2 gene SNP affects the susceptibility to benazepril20559404
C044946benazepril[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril21449848
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ACE2 mRNA26377693
D001623BetamethasoneBetamethasone results in decreased expression of ACE2 protein19047579
C006780bisphenol Abisphenol A results in decreased expression of ACE2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ACE2 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ACE2 promoter22457795
C081643candesartancandesartan results in decreased expression of ACE2 mRNA18796534
C077793candesartan cilexetilcandesartan cilexetil results in increased expression of ACE2 protein22120037
D000068579CelecoxibCelecoxib results in increased expression of ACE2 mRNA28201806
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ACE2 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACE2 mRNA25511041
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACE2 protein25511041
D019327Copper SulfateCopper Sulfate results in decreased expression of ACE2 mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of ACE2 mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of ACE2 mRNA21865292
D004041Dietary FatsDietary Fats affects the expression of ACE2 mRNA18796534
C003915diminazene aceturatediminazene aceturate results in increased expression of ACE2 mRNA25301841
C003915diminazene aceturatediminazene aceturate results in increased expression of ACE2 protein25301841
D004317DoxorubicinDoxorubicin results in increased expression of ACE2 mRNA28940058
C556151DX600 peptideDX600 peptide results in decreased activity of ACE2 protein20178811
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of ACE2 mRNA25198161
D017316FadrozoleFadrozole results in increased expression of ACE2 protein18586661
C412815GW 4064GW 4064 results in increased expression of ACE2 mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ACE2 mRNA26846883
C081309irbesartanACE2 gene polymorphism affects the susceptibility to irbesartan11593098
D007545IsoproterenolIsoproterenol results in increased expression of ACE2 mRNA20003209
D007545IsoproterenolIsoproterenol results in increased expression of ACE2 protein20409916
C008261lead acetatelead acetate results in decreased expression of ACE2 mRNA22613225
D019808LosartanLosartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]25511041
D019808LosartanLosartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]16176966
D019808LosartanLosartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]16176966
D019808LosartanLosartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]20178811
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACE2 mRNA"25554681
D009532NickelNickel results in increased expression of ACE2 mRNA24768652
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ACE2 mRNA19074003
C437965olmesartanolmesartan results in increased expression of ACE2 mRNA19171689
D009966OrphenadrineOrphenadrine affects the expression of ACE2 mRNA23665939
D010100OxygenLosartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]25511041
D010100OxygenOxygen deficiency results in decreased expression of ACE2 mRNA25511041
D010100OxygenOxygen deficiency results in decreased expression of ACE2 protein25511041
D010269ParaquatParaquat results in decreased expression of ACE2 mRNA20465954
D010269ParaquatUnithiol inhibits the reaction [Paraquat results in decreased expression of ACE2 mRNA]20465954
C046012pentanalpentanal results in increased expression of ACE2 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ACE2 mRNA24667235
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ACE2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACE2 mRNA19710929
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNA17639512
D012834SilverSilver results in increased expression of ACE2 mRNA26277626
D020123SirolimusSirolimus results in decreased expression of ACE2 mRNA21865292
C016104sodium bichromatesodium bichromate results in decreased expression of ACE2 mRNA24612858
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of ACE2 mRNA"18796534
D053260SootSoot results in decreased expression of ACE2 mRNA26551751
D013148SpironolactoneSpironolactone results in increased expression of ACE2 protein18586661
D013311StreptozocinStreptozocin results in decreased expression of ACE2 protein21381899
D013311Streptozocintelmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]21381899
D013311StreptozocinACE2 inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]20844835
D013311StreptozocinACE2 inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]20844835
D013311StreptozocinACE2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]20844835
D016559TacrolimusTacrolimus results in decreased expression of ACE2 mRNA21865292
C084178telmisartantelmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]21381899
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ACE2 mRNA19074003
C009495titanium dioxidetitanium dioxide results in increased expression of ACE2 mRNA26277626
C009495titanium dioxidetitanium dioxide results in increased expression of ACE2 protein26277626
D014028Tobacco Smoke PollutionLosartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]20178811
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACE2 protein20178811
C052035trandolapriltrandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein]27428043
D014260TriclosanTriclosan results in decreased expression of ACE2 mRNA28940058
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACE2 mRNA"26743178
D014494UnithiolUnithiol inhibits the reaction [Paraquat results in decreased expression of ACE2 mRNA]20465954
D014635Valproic AcidValproic Acid affects the expression of ACE2 mRNA25979313
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]16176966
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of ACE2 mRNA"25198161
C009689xanthonexanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]25205467
C009689xanthonexanthone inhibits the reaction [LEP protein results in increased expression of ACE2]25205467

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IDA18343844  
GO:0001618virus receptor activity-IMP24227843  
GO:0004175endopeptidase activity-IDA15283675  
GO:0004180carboxypeptidase activity-IBA21873635  
GO:0004180carboxypeptidase activity-IDA10924499  10969042  15283675  15380922  18258853  
GO:0004181metallocarboxypeptidase activity-EXP10924499  10969042  11815627  
GO:0005515protein binding-IPI18343844  19185582  21068237  
GO:0008237metallopeptidase activityNOTIDA10924499  
GO:0008238exopeptidase activity-IBA21873635  
GO:0008241peptidyl-dipeptidase activityNOTIDA10924499  
GO:0008270zinc ion binding-TAS10924499  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-IC15380922  
GO:0002003angiotensin maturation-IC10924499  
GO:0002003angiotensin maturation-TAS-  
GO:0003051angiotensin-mediated drinking behavior-IMP18258853  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IBA21873635  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IC10924499  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IMP18258853  
GO:0015827tryptophan transport-IEA-  
GO:0019229regulation of vasoconstriction-IC15380922  
GO:0032800receptor biosynthetic process-IMP18258853  
GO:0042127regulation of cell proliferation-TAS17703127  
GO:0046718viral entry into host cell-TAS15165741  
GO:0046813receptor-mediated virion attachment to host cell-IDA18343844  
GO:0050727regulation of inflammatory response-IC15380922  
GO:0051957positive regulation of amino acid transport-IMP19185582  
GO:0060452positive regulation of cardiac muscle contraction-IEA-  
GO:0097746regulation of blood vessel diameter-IC15380922  
GO:1903598positive regulation of gap junction assembly-IMP12967627  
GO:1903779regulation of cardiac conduction-IMP12967627  
GO:2000379positive regulation of reactive oxygen species metabolic process-IC15380922  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA10969042  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA18258853  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA21068237  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA18343844  24227843  
GO:0016021integral component of membrane-IEA-  
GO:0031526brush border membrane-IEA-  
GO:0045121membrane raft-TAS18279660  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04614Renin-angiotensin system
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-2022377Metabolism of Angiotensinogen to AngiotensinsTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24636159Association between serum angiotensin-converting enzyme 2 level with postoperative morbidity and mortality after major pulmonary resection in non-small cell lung cancer patients. (2014 Jul)Li XHeart Lung Circ
12419208Just the beginning: novel functions for angiotensin-converting enzymes. (2002 Oct 29)Eriksson UCurr Biol
23477970Impact of interaction of cigarette smoking with angiotensin-converting enzyme polymorphisms on end-stage renal disease risk in a Han Chinese population. (2015 Mar)Yang HYJ Renin Angiotensin Aldosterone Syst
24417403Angiotensin-converting enzyme-2 overexpression attenuates inflammation in rat model of chronic obstructive pulmonary disease. (2014 Jan)Xue TInhal Toxicol
24191856The association between the Angiotensin-Converting Enzyme-2 gene and blood pressure in a cohort study of adolescents. (2013 Nov 5)Malard LBMC Med Genet
24926374Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting. (2014 Jun)Wang MExp Ther Med
26112236Association Between Angiotensin-Converting Enzyme 2 and Coronary Artery Calcification in Patients on Maintenance Hemodialysis Therapy. (2015 Oct)Zhang QTher Apher Dial
20178811Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2. (2010 May 15)Han SXToxicol Appl Pharmacol
25795458Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats. (2015 Jun)Yuan YMJ Renin Angiotensin Aldosterone Syst
27615597Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease. (2016 Oct)Anguiano LAtherosclerosis
28223093Association between circulating angiotensin-converting enzyme 2 and cardiac remodeling in hypertensive patients. (2017 Apr)Li SPeptides