Gene: RBBP7

5931
RbAp46
RB binding protein 7, chromatin remodeling factor
protein-coding
Xp22.2
Ensembl:ENSG00000102054 MIM:300825 Vega:OTTHUMG00000021198 UniprotKB:Q16576
NC_000023.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XRCC60.936
CDC1230.936
UBR70.931
PSMD60.931
PSMC20.93
GLT8D10.928
GDI20.928
KPNB10.926
FHL10.926
HNRNPH20.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.785
OR4F29-0.744
MTRNR2L6-0.263
MTRNR2L9-0.242
MTRNR2L10-0.22
KLRB1-0.214
C9orf153-0.207
TTLL10-0.2
ZBTB20-0.193
C8orf74-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RBBP7 mRNA"21354444
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RBBP7 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RBBP7 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of RBBP7 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of RBBP7 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RBBP7 mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of RBBP7 mRNA16514628
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RBBP7 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RBBP7 mRNA22342234
D004958EstradiolEstradiol promotes the reaction [RBBP7 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in increased expression of RBBP7 mRNA16514628
C006780bisphenol Abisphenol A results in decreased expression of RBBP7 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of RBBP7 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of RBBP7 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of RBBP7 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RBBP7 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of RBBP7 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RBBP7 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of RBBP7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RBBP7 mRNA25562108
D002945CisplatinCisplatin results in increased phosphorylation of RBBP7 protein22006019
C000944dicrotophosdicrotophos results in decreased expression of RBBP7 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RBBP7 mRNA"22485181
D011397Promegestonemethoxyacetic acid promotes the reaction [Promegestone results in increased expression of RBBP7 mRNA]15103026
D011397PromegestonePromegestone results in increased expression of RBBP7 mRNA15103026
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBBP7 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBBP7 mRNA17942748
D018120FinasterideFinasteride results in increased expression of RBBP7 mRNA24136188
D005485FlutamideFlutamide results in increased expression of RBBP7 mRNA24136188
C070081fulvestrantfulvestrant results in decreased expression of RBBP7 mRNA16514628
C039281furanfuran results in increased expression of RBBP7 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of RBBP7 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of RBBP7 mRNA22634610
D017313FenretinideFenretinide results in increased expression of RBBP7 mRNA28973697
D006854HydrocortisoneRBBP7 protein affects the susceptibility to Hydrocortisone12767060
D019266Iron, Dietary"Iron, Dietary affects the expression of RBBP7 mRNA"15637178
C045463leflunomideleflunomide results in decreased expression of RBBP7 mRNA28988120
C013598methoxyacetic acidmethoxyacetic acid promotes the reaction [Promegestone results in increased expression of RBBP7 mRNA]15103026
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to RBBP7 promoter]20348232
D016685MitomycinMitomycin results in increased expression of RBBP7 mRNA12760830
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of RBBP7 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of RBBP7 mRNA21195148
C051752nefazodonenefazodone results in increased expression of RBBP7 mRNA24136188
C017557nickel subsulfidenickel subsulfide results in increased expression of RBBP7 mRNA21086188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RBBP7 mRNA20971185
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RBBP7 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of RBBP7 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of RBBP7 mRNA23811191
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of RBBP7 protein15798086
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of RBBP7 mRNA16514628
C016104sodium bichromatesodium bichromate results in increased expression of RBBP7 mRNA12760830
D013467SulindacSulindac results in increased expression of RBBP7 mRNA24136188
D013739TestosteroneTestosterone results in increased expression of RBBP7 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RBBP7 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBBP7 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RBBP7 mRNA17949056
D013853ThioacetamideThioacetamide results in increased expression of RBBP7 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of RBBP7 mRNA16604517
D014501UraniumUranium affects the expression of RBBP7 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of RBBP7 mRNA15672453

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0004407histone deacetylase activity-TAS-  
GO:0005515protein binding-IPI7503932  9150135  18571423  19497860  19703393  19862764  
21258344  22720776  23752268  25150861  26496610  27705803  
28179136  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006260DNA replication-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-TAS7503932  
GO:0008283cell proliferation-TAS7503932  
GO:0016575histone deacetylation-IEA-  
GO:0030308negative regulation of cell growth-IDA9765217  
GO:0034080CENP-A containing nucleosome assembly-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0045814negative regulation of gene expression, epigenetic-TAS-  
GO:0048545response to steroid hormone-IEA-  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO:0070370cellular heat acclimation-IDA7503932  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA16791210  
GO:0005634nucleus-IDA22720776  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0016581NuRD complex-IDA19644445  22926524  
GO:0035098ESC/E(Z) complex-IDA20075857  23104054  23273982  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212300PRC2 methylates histones and DNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3214847HATs acetylate histonesTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionIEA
R-HSA-4839726Chromatin organizationTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionIEA
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromereTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-774815Nucleosome assemblyTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8951664NeddylationTAS
R-HSA-8953750Transcriptional Regulation by E2F6TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17295719Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. (2007 Mar)Wang JAlcohol Clin Exp Res