Gene: PRDM12

59335
HSAN8|PFM9
PR/SET domain 12
protein-coding
9q34.12
Ensembl:ENSG00000130711 MIM:616458 Vega:OTTHUMG00000020808 UniprotKB:Q9H4Q4
NG_053081.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.268e-2 (AD)  8.871e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11244096chr9:130675957 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ORC60.761
HENMT10.76
JAKMIP10.759
WDR540.757
EID2B0.755
EID20.752
KLHL350.749
CYP4X10.748
NUDT100.747
FAM216A0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CARD8-0.528
FYCO1-0.479
SYDE1-0.469
RAI14-0.468
MAML2-0.455
REST-0.455
MTRNR2L9-0.452
EBF1-0.446
HVCN1-0.446
YES1-0.443

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of PRDM12 mRNA]24530881
D000082AcetaminophenAcetaminophen results in increased expression of PRDM12 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRDM12 mRNA21641981
C015001arsenitearsenite results in increased methylation of PRDM12 promoter23974009
D001280AtrazineAtrazine results in decreased expression of PRDM12 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PRDM12 gene25435355
C006780bisphenol Abisphenol A affects the expression of PRDM12 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDM12 mRNA26472689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRDM12 gene20938992
D003300CopperCopper deficiency results in increased expression of PRDM12 mRNA26033743
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PRDM12 mRNA23550701
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRDM12 gene20938992
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of PRDM12 mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of PRDM12 mRNA24530881
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRDM12 mRNA27432991
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRDM12 gene20938992
D010936Plant ExtractsPlant Extracts results in decreased expression of PRDM12 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of PRDM12 mRNA18070364
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PRDM12 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of PRDM12 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of PRDM12 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of PRDM12 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of PRDM12 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0008168methyltransferase activity-IEA-  
GO:0031490chromatin DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:1990226histone methyltransferase binding-IBA21873635  
GO:1990226histone methyltransferase binding-IDA26005867  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0019233sensory perception of pain-IMP26005867  
GO:0022008neurogenesis-IBA21873635  
GO:0031175neuron projection development-IMP26005867  
GO:0032259methylation-IEA-  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-IMP26005867  
GO:0051574positive regulation of histone H3-K9 methylation-IBA21873635  
GO:0051574positive regulation of histone H3-K9 methylation-IDA26005867  
GO:1900111positive regulation of histone H3-K9 dimethylation-IBA21873635  
GO:1900111positive regulation of histone H3-K9 dimethylation-IMP26005867  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA26005867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal