Gene: HRH4

59340
AXOR35|BG26|GPCR105|GPRv53|H4|H4R|HH4R
histamine receptor H4
protein-coding
18q11.2
Ensembl:ENSG00000134489 MIM:606792 Vega:OTTHUMG00000131945 UniprotKB:Q9H3N8
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.641e-1 (AD)  6.286e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LTA0.55
RAX20.545
SIX40.523
EPPIN0.499
JMJD60.498
P4HA20.495
CHORDC10.487
MICB0.485
C9orf1520.482
DNAJB40.477

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC29-0.318
ISM1-0.3
CYB561D2-0.294
ZSCAN1-0.287
CHMP6-0.277
SLC25A10-0.276
HMGB3-0.275
CRYBB1-0.273
C10orf67-0.272
NUDT18-0.27

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB05032REV131Small Molecule-InvestigationalTarget
DB05381HistamineSmall Molecule51-45-6Approved|InvestigationalTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4843091-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]17507084
C4843091-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]17507084
C4843091-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to clobenpropit]22363581
C4843091-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to Histamine]22363581
C4843091-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine binds to and results in decreased activity of HRH4 protein18782117|1965246
C0857554-(1H-imidazol-4-ylmethyl)piperidine4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH4 protein12065605
C0255664-methylhistamine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]17507084
C0255664-methylhistamine4-methylhistamine binds to and results in increased activity of HRH4 protein17507084
C0255664-methylhistamine[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium17507084
C069357alpha-methylhistaminealpha-methylhistamine binds to and results in increased activity of HRH4 protein11181941
C069357alpha-methylhistamine[alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
C069357alpha-methylhistamineHRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein]12235264
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HRH4 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HRH4 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of HRH4 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of HRH4 mRNA24586524
C006780bisphenol Abisphenol A results in increased expression of HRH4 mRNA25181051
D002118Calcium1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]17507084
D002118Calcium1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]17507084
D002118Calcium[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium17507084
D002118Calcium[alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
D002118Calcium[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium17507084
D002118Calcium[Histamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
D002118Calcium[imetit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
D002118Calcium[N-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
C086108clobenpropit1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]17507084
C086108clobenpropit1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to clobenpropit]22363581
C086108clobenpropitclobenpropit binds to and results in increased activity of HRH4 protein17507084
C086108clobenpropit[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium17507084
C086108clobenpropitclobenpropit binds to HRH4 protein22003888
C086108clobenpropitHRH4 protein results in increased susceptibility to clobenpropit22363581
C086108clobenpropit[HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein22363581
C086108clobenpropit[HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein22363581
C086108clobenpropit[HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein22363581
C086108clobenpropit[HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein22363581
C086108clobenpropitclobenpropit binds to and results in increased activity of HRH4 protein17346280|2236358
D003024ClozapineClozapine binds to and results in increased activity of HRH4 protein17346280
D003471CuprizoneCuprizone affects the expression of HRH4 mRNA27523638
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of HRH4 mRNA]21095227
D004041Dietary FatsDietary Fats results in increased expression of HRH4 mRNA25016146
D017259DimapritDimaprit binds to and results in increased activity of HRH4 protein17346280
C069837fullerene C60fullerene C60 results in decreased expression of HRH4 mRNA19167457
D016244Guanosine 5'-O-(3-Thiotriphosphate)Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein11181941
D016244Guanosine 5'-O-(3-Thiotriphosphate)Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein]11181941
D006632Histamine1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to Histamine]22363581
D006632HistamineHistamine binds to and results in increased activity of HRH4 protein11181941
D006632Histamine[Histamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
D006632Histamine[Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein11181941
D006632Histamine[Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein11181941
D006632HistamineHistamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein]11181941
D006632HistamineHistamine results in increased activity of HRH4 protein15843518
D006632Histamine[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein15843518
D006632Histamine[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein15843518
D006632HistamineHRH4 protein results in increased susceptibility to Histamine22363581
D006632Histamine[HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein22363581
D006632Histamine[HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein22363581
D006632Histamine[HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein22363581
D006632Histamine[HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein22363581
D006632HistamineU 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]15843518
D006632HistamineU 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein]15843518
D006632HistamineHistamine results in increased activity of HRH4 protein22363581
C077430imetitimetit binds to and results in increased activity of HRH4 protein11181941
C077430imetit[imetit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HRH4 mRNA15665042
D008727MethotrexateMethotrexate results in decreased expression of HRH4 mRNA24449571
C028007nickel monoxidenickel monoxide results in decreased expression of HRH4 mRNA19167457
C048140N-methylhistamineN-methylhistamine binds to and results in increased activity of HRH4 protein11181941
C048140N-methylhistamine[N-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium11181941
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [HRH4 protein results in increased expression of IL16 protein]12235264
D010795Phthalic AcidsPhthalic Acids results in decreased expression of HRH4 mRNA21061450
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of HRH4 mRNA]21095227
C052075thioperamidethioperamide results in decreased activity of HRH4 protein22995146
C052075thioperamidethioperamide binds to and results in decreased activity of HRH4 protein19703484|2292604
D014212TretinoinTretinoin results in decreased expression of HRH4 mRNA27368152
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of HRH4 mRNA24561612
C113580U 0126U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]15843518
C113580U 0126U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein]15843518
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HRH4 gene25560391
D019287Zinc SulfateZinc Sulfate results in decreased expression of HRH4 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004969histamine receptor activity-NAS10973974  11118334  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0016907G-protein coupled acetylcholine receptor activity-IBA21873635  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007197adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0008150biological_process-ND-  
GO:0043408regulation of MAPK cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390650Histamine receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27421833Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test. (2016)Zuiker RGEur Clin Respir J