Gene info: ID 59341

Gene: TRPV4

GENE ID: 59341

Description: transient receptor potential cation channel subfamily V member 4

Gene type: protein-coding

Location: 12q24.11

dbXrefs: Ensembl:ENSG00000111199 MIM:605427 Vega:OTTHUMG00000169277 UniprotKB:Q9HBA0

RefSeq: NG_017090.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.237e-1 (AD) 7.918e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LILRB2	0.821
EMILIN2	0.818
ALPK1	0.809
SPTLC3	0.8
SLC16A5	0.797
PARP15	0.796
TNFAIP8	0.794
SLFN12	0.787
CASP4	0.787
CIITA	0.786

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.517
NEUROD6	-0.502
EXTL1	-0.493
TMEM179	-0.482
WNT7A	-0.479
MYADML2	-0.472
ASPDH	-0.47
ATOH7	-0.464
RTN4R	-0.462
LRTM2	-0.46

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of TRPV4 mRNA"	26377693
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cyclic AMP results in increased expression of TRPV4 mRNA]	22187434
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cyclic AMP results in increased expression of TRPV4 protein]	22187434
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of TRPV4 mRNA	19191707
C040776	5,6-epoxy-8,11,14-eicosatrienoic acid	"5,6-epoxy-8,11,14-eicosatrienoic acid results in increased activity of TRPV4 protein"	22187434
C040776	5,6-epoxy-8,11,14-eicosatrienoic acid	"[5,6-epoxy-8,11,14-eicosatrienoic acid results in increased activity of TRPV4 protein] which results in increased transport of Calcium"	22187434
D000082	Acetaminophen	Acetaminophen results in increased expression of TRPV4 mRNA	22230336
D020106	Acrylamide	Acrylamide results in decreased expression of TRPV4 mRNA	28959563
D000242	Cyclic AMP	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cyclic AMP results in increased expression of TRPV4 mRNA]	22187434
D000242	Cyclic AMP	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cyclic AMP results in increased expression of TRPV4 protein]	22187434
D000242	Cyclic AMP	Cyclic AMP results in increased expression of TRPV4 mRNA	22187434
D000242	Cyclic AMP	Cyclic AMP results in increased expression of TRPV4 protein	22187434
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of TRPV4 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TRPV4 mRNA	16483693
C078814	anandamide	anandamide results in increased activity of TRPV4 protein	22187434
D016718	Arachidonic Acid	Arachidonic Acid results in increased activity of TRPV4 protein	20956320
D016718	Arachidonic Acid	Arachidonic Acid results in increased activity of TRPV4 protein	22187434
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TRPV4 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TRPV4 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of TRPV4 mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TRPV4 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TRPV4 mRNA	27195522
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRPV4 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of TRPV4 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased methylation of TRPV4 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of TRPV4 mRNA	25181051
D019328	Buthionine Sulfoximine	[Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine	20064552
D019328	Buthionine Sulfoximine	[Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine	20064552
D002118	Calcium	"TRPV4 protein promotes the reaction [phorbol-12,13-didecanoate results in increased import of Calcium]"	18355916
D002118	Calcium	TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]	18234883
D002118	Calcium	"[5,6-epoxy-8,11,14-eicosatrienoic acid results in increased activity of TRPV4 protein] which results in increased transport of Calcium"	22187434
D002211	Capsaicin	Capsaicin results in increased expression of TRPV4 mRNA	16278290
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPV4 mRNA	20938992
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TRPV4 mRNA	27858113
C012843	cinnamic aldehyde	cinnamic aldehyde inhibits the reaction [IL1B protein results in increased expression of TRPV4 mRNA]	18310904
C012843	cinnamic aldehyde	cinnamic aldehyde inhibits the reaction [IL1B protein results in increased expression of TRPV4 protein]	18310904
D003471	Cuprizone	Cuprizone results in increased expression of TRPV4 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of TRPV4 mRNA	27989131
D016047	Zalcitabine	TRPV4 protein results in increased susceptibility to Zalcitabine	18234883
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRPV4 mRNA	28628672
D004237	Diuron	Diuron results in increased expression of TRPV4 mRNA	21551480
D015777	Eicosanoids	Eicosanoids affects the activity of TRPV4 protein	19666518
D000431	Ethanol	Ethanol results in increased expression of [ITGA2 protein binds to LYN protein binds to TRPV4 protein]	18234883
D000431	Ethanol	TRPV4 protein results in increased susceptibility to Ethanol	18234883
C082360	fipronil	fipronil results in decreased expression of TRPV4 mRNA	23962444
D005419	Flavonoids	Flavonoids results in decreased expression of TRPV4 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPV4 mRNA	20938992
C039281	furan	furan results in increased expression of TRPV4 mRNA	27387713
D005682	Gadolinium	Gadolinium results in decreased activity of TRPV4 protein	20064552
D005682	Gadolinium	[Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine	20064552
D005839	Gentamicins	Gentamicins results in increased expression of TRPV4 mRNA	22061828
D005944	Glucosamine	Glucosamine results in increased expression of TRPV4 mRNA	17178593
D017313	Fenretinide	Fenretinide results in increased expression of TRPV4 mRNA	28973697
D012701	Serotonin	TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]	18234883
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of TRPV4 mRNA"	26377693
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRPV4 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TRPV4 mRNA	28628672
C008261	lead acetate	lead acetate affects the expression of TRPV4 mRNA	21864555
C008261	lead acetate	lead acetate results in decreased expression of TRPV4 mRNA	22641619
C045463	leflunomide	leflunomide results in increased expression of TRPV4 mRNA	28988120
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPV4 mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to TRPV4 promoter]	20348232
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TRPV4 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRPV4 mRNA"	26251327
C530602	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	"N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide binds to and results in increased activity of TRPV4 protein"	21964574
C530602	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	"N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide results in increased activity of TRPV4 protein"	20956320
D015232	Dinoprostone	TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]	18234883
C008876	phorbol-12,13-didecanoate	"phorbol-12,13-didecanoate binds to and results in increased activity of TRPV4 protein"	18587396\|2196457
C008876	phorbol-12,13-didecanoate	"phorbol-12,13-didecanoate results in increased activity of TRPV4 protein"	20956320
C008876	phorbol-12,13-didecanoate	"TRPV4 protein promotes the reaction [phorbol-12,13-didecanoate results in increased import of Calcium]"	18355916
C008876	phorbol-12,13-didecanoate	"phorbol-12,13-didecanoate binds to and results in increased activity of TRPV4 protein"	19029406
C008876	phorbol-12,13-didecanoate	"phorbol-12,13-didecanoate results in increased activity of TRPV4 protein"	19075100\|1920825
D059808	Polyphenols	Polyphenols results in increased expression of TRPV4 mRNA	16293270
D012430	Ruthenium Red	Ruthenium Red results in decreased activity of TRPV4 protein	20064552
D012430	Ruthenium Red	[Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine	20064552
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [IL1B protein results in increased expression of TRPV4 mRNA]	18310904
D012430	Ruthenium Red	Ruthenium Red inhibits the reaction [IL1B protein results in increased expression of TRPV4 protein]	18310904
D012430	Ruthenium Red	Ruthenium Red results in decreased activity of TRPV4 protein	19075100
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of TRPV4 mRNA	25895662
D012964	Sodium	TRPV4 gene polymorphism affects the abundance of Sodium	19666518
C017947	sodium arsenite	sodium arsenite results in decreased expression of TRPV4 mRNA	24570342
C017947	sodium arsenite	sodium arsenite results in increased methylation of TRPV4 gene	24570342
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in increased expression of TRPV4 protein"	19075100
D013311	Streptozocin	TRPV4 protein results in increased susceptibility to Streptozocin	18234883
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRPV4 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRPV4 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRPV4 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRPV4 mRNA	26290441
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of TRPV4 mRNA	22882778
C057693	troglitazone	troglitazone results in increased expression of TRPV4 mRNA	28973697
D001335	Vehicle Emissions	TRPV4 mutant form inhibits the reaction [F2RL1 protein modified form promotes the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]]	21245013
D001335	Vehicle Emissions	TRPV4 mutant form inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]	21245013
D001335	Vehicle Emissions	TRPV4 mutant form inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]	21245013
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [PLCB3 protein binds to TRPV4 protein]	21245013
D014750	Vincristine	TRPV4 protein results in increased susceptibility to Vincristine	18234883

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003779	actin binding	-	ISS	-
GO:0005034	osmosensor activity	-	IEA	-
GO:0005080	protein kinase C binding	-	ISS	-
GO:0005216	ion channel activity	-	IBA	21873635
GO:0005261	cation channel activity	-	IDA	12724311
GO:0005262	calcium channel activity	-	IBA	21873635
GO:0005262	calcium channel activity	-	IDA	18458941
GO:0005262	calcium channel activity	-	TAS	-
GO:0005515	protein binding	-	IPI	16293632 21262839
GO:0005516	calmodulin binding	-	IMP	12724311
GO:0005524	ATP binding	-	IEA	-
GO:0008017	microtubule binding	-	ISS	-
GO:0008289	lipid binding	-	IEA	-
GO:0015275	stretch-activated, cation-selective, calcium channel activity	-	IMP	23136043
GO:0019901	protein kinase binding	-	IPI	12538589
GO:0042169	SH2 domain binding	-	ISS	-
GO:0042802	identical protein binding	-	IPI	26146187
GO:0043014	alpha-tubulin binding	-	ISS	-
GO:0046872	metal ion binding	-	IEA	-
GO:0048487	beta-tubulin binding	-	ISS	-
GO:0051015	actin filament binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0002024	diet induced thermogenesis	-	IEA	-
GO:0006816	calcium ion transport	-	IDA	18458941
GO:0006816	calcium ion transport	-	NAS	11025659
GO:0006874	cellular calcium ion homeostasis	-	IBA	21873635
GO:0006874	cellular calcium ion homeostasis	-	IDA	12724311
GO:0006884	cell volume homeostasis	-	TAS	12724311
GO:0007015	actin filament organization	-	IBA	21873635
GO:0007015	actin filament organization	-	ISS	-
GO:0007043	cell-cell junction assembly	-	ISS	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IDA	18458941
GO:0007231	osmosensory signaling pathway	-	IBA	21873635
GO:0007231	osmosensory signaling pathway	-	ISS	-
GO:0007231	osmosensory signaling pathway	-	TAS	12724311
GO:0009612	response to mechanical stimulus	-	TAS	15753126
GO:0010628	positive regulation of gene expression	-	IEA	-
GO:0010759	positive regulation of macrophage chemotaxis	-	IEA	-
GO:0010977	negative regulation of neuron projection development	-	ISS	-
GO:0030103	vasopressin secretion	-	IEA	-
GO:0031117	positive regulation of microtubule depolymerization	-	ISS	-
GO:0031532	actin cytoskeleton reorganization	-	ISS	-
GO:0032868	response to insulin	-	IEA	-
GO:0034605	cellular response to heat	-	ISS	-
GO:0042538	hyperosmotic salinity response	-	IEA	-
GO:0042593	glucose homeostasis	-	IEA	-
GO:0043117	positive regulation of vascular permeability	-	IMP	23136043
GO:0043622	cortical microtubule organization	-	ISS	-
GO:0046330	positive regulation of JNK cascade	-	IEA	-
GO:0046785	microtubule polymerization	-	ISS	-
GO:0047484	regulation of response to osmotic stress	-	IEA	-
GO:0050729	positive regulation of inflammatory response	-	IEA	-
GO:0050891	multicellular organismal water homeostasis	-	IMP	23136043
GO:0060351	cartilage development involved in endochondral bone morphogenesis	-	IMP	26249260
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0070509	calcium ion import	-	ISS	-
GO:0070588	calcium ion transmembrane transport	-	IMP	23136043
GO:0070588	calcium ion transmembrane transport	-	TAS	-
GO:0071470	cellular response to osmotic stress	-	ISS	-
GO:0071476	cellular hypotonic response	-	IBA	21873635
GO:0071476	cellular hypotonic response	-	IMP	23136043
GO:0071476	cellular hypotonic response	-	ISS	-
GO:0071477	cellular hypotonic salinity response	-	IEA	-
GO:0071639	positive regulation of monocyte chemotactic protein-1 production	-	IEA	-
GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	-	IEA	-
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	-	IEA	-
GO:0097009	energy homeostasis	-	IEA	-
GO:0097497	blood vessel endothelial cell delamination	-	IMP	23136043
GO:1903444	negative regulation of brown fat cell differentiation	-	IEA	-
GO:1903759	signal transduction involved in regulation of aerobic respiration	-	IEA	-
GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	-	IEA	-
GO:2000778	positive regulation of interleukin-6 secretion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005881	cytoplasmic microtubule	colocalizes_with	ISS	-
GO:0005886	plasma membrane	-	IDA	15753126 23136043
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005912	adherens junction	-	ISS	-
GO:0005925	focal adhesion	-	ISS	-
GO:0005929	cilium	-	IBA	21873635
GO:0009986	cell surface	-	IEA	-
GO:0016021	integral component of membrane	-	NAS	11025659
GO:0016324	apical plasma membrane	-	IEA	-
GO:0030027	lamellipodium	-	ISS	-
GO:0030175	filopodium	-	ISS	-
GO:0030426	growth cone	-	ISS	-
GO:0030864	cortical actin cytoskeleton	-	ISS	-
GO:0031410	cytoplasmic vesicle	-	IEA	-
GO:0032587	ruffle membrane	-	ISS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-3295583	TRP channels	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22443337	Transient receptor potential genes, smoking, occupational exposures and cough in adults. (2012 Mar 23)	Smit LA	Respir Res
18234883	Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. (2008 Jan 30)	Alessandri-Haber N	J Neurosci
25301060	Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung. (2014 Dec)	Baxter M	Thorax