Gene: LGR6

59352
GPCR|VTS20631
leucine rich repeat containing G protein-coupled receptor 6
protein-coding
1q32.1
Ensembl:ENSG00000133067 MIM:606653 Vega:OTTHUMG00000041383 UniprotKB:Q9HBX8
NC_000001.11
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.260e-1 (AD)  8.552e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs116439821chr1:202215693 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13385220chr1:202250453LGR61.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC60.405
SLC22A60.399
HCRTR10.379
DNAJB50.377
CRABP10.373
NDNF0.369
GPC30.369
OR1L30.367
PDGFD0.364
TXNDC170.357

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTN5-0.249
ZNF732-0.247
C12orf56-0.246
IGFALS-0.244
IQCF1-0.237
CNGA4-0.234
PVRIG-0.234
OXCT2-0.233
FUT7-0.231
SPATA21-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LGR6 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LGR6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LGR6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LGR6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LGR6 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LGR6 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LGR6 mRNA19770486
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LGR6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LGR6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LGR6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LGR6 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of LGR6 mRNA20003209
C523799MRK 003MRK 003 results in increased expression of LGR6 mRNA21169257
D009532NickelNickel results in decreased expression of LGR6 mRNA24768652|2558310
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LGR6 mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LGR6 mRNA19710929
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LGR6 mRNA25895662
D012834SilverSilver results in increased expression of LGR6 mRNA27131904
D013849ThimerosalThimerosal results in increased expression of LGR6 mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of LGR6 mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LGR6 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of LGR6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of LGR6 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-ISS-  
GO:0004930G-protein coupled receptor activityNOTISS-  
GO:0005515protein binding-IPI21727895  22615920  
GO:0016500protein-hormone receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-IDA22615920  
GO:0030335positive regulation of cell migration-IDA22615920  
GO:0090263positive regulation of canonical Wnt signaling pathway-ISS-  
GO:1990523bone regeneration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0031982vesicle-IDA22615920  
GO:0032588trans-Golgi network membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal