Gene: CPLX3

594855
CPX-III|CPXIII|Nbla11589
complexin 3
protein-coding
15q24.1
Ensembl:ENSG00000213578 MIM:609585 Vega:OTTHUMG00000142816 UniprotKB:Q8WVH0
NC_000015.10
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.746e-1 (AD)  4.025e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIT0.788
KCNIP30.756
VIP0.744
ELFN10.717
PTHLH0.71
DLX10.709
NPAS10.685
FLRT10.683
WNT7A0.681
CAMK2N20.681

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC4E-0.572
CP-0.569
MPZL2-0.552
C1orf87-0.549
CDA-0.534
OSMR-0.534
IL4R-0.533
GABRE-0.531
RNASE2-0.527
CLEC2B-0.522

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of CPLX3 mRNA17562736
D001280AtrazineAtrazine results in increased expression of CPLX3 mRNA22378314
D003300CopperCopper deficiency results in increased expression of CPLX3 mRNA26033743
D003976DiazinonDiazinon results in increased expression of CPLX3 mRNA29108742
D019422Dietary SucroseDietary Sucrose results in increased expression of CPLX3 mRNA26033743
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CPLX3 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CPLX3 mRNA18936297
C029310lardlard results in increased expression of CPLX3 mRNA26115784
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CPLX3 mRNA24810058
D010936Plant ExtractsPlant Extracts results in decreased expression of CPLX3 mRNA23557933
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of CPLX3 mRNA23274088
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of CPLX3 mRNA23274088
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CPLX3 mRNA28973375
D014212TretinoinTretinoin results in decreased expression of CPLX3 mRNA23724009
C011559tributyltintributyltin results in increased expression of CPLX3 mRNA21683754
D014635Valproic AcidValproic Acid results in increased methylation of CPLX3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005326neurotransmitter transporter activity-IEA-  
GO:0019905syntaxin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IEA-  
GO:0030073insulin secretion-IEA-  
GO:0046928regulation of neurotransmitter secretion-IBA21873635  
GO:0046928regulation of neurotransmitter secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0031201SNARE complex-IBA21873635  
GO:0043195terminal bouton-IBA21873635  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry