Gene: NPS

594857
-
neuropeptide S
protein-coding
10q26.2
Ensembl:ENSG00000214285 MIM:609513 Vega:OTTHUMG00000188145 UniprotKB:P0C0P6
NC_000010.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.301e-1 (AD)  7.996e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4C110.78
OR4D50.718
OR4S20.714
OR4A150.702
OR5A10.692
TCHHL10.689
OR4C50.684
OR51B20.684
KRTAP6-20.677
OR5T20.677

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BGLAP-0.229
C1orf134-0.226
HSPB2-0.219
NTSR2-0.191
FAM43B-0.191
ATP6AP1L-0.187
MMP15-0.185
NDP-0.185
SOX15-0.178
CHST5-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5294933-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide"3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate]"21466221
C006780bisphenol Abisphenol A results in decreased expression of NPS mRNA25181051
D016291Dizocilpine Maleate"3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate]"21466221
D016291Dizocilpine MaleateNPS protein results in decreased activity of Dizocilpine Maleate21466221
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of NPS mRNA22563483
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of NPS mRNA22563483
D010269ParaquatParaquat results in increased expression of NPS mRNA22563483
C428725pyridabenpyridaben results in increased expression of NPS mRNA22563483

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0008542visual learning-IEA-  
GO:0010841positive regulation of circadian sleep/wake cycle, wakefulness-IEA-  
GO:0032230positive regulation of synaptic transmission, GABAergic-IBA21873635  
GO:0032230positive regulation of synaptic transmission, GABAergic-IEA-  
GO:0045760positive regulation of action potential-IBA21873635  
GO:0045760positive regulation of action potential-IEA-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IBA21873635  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19251112Effects of forced alcohol drinking on alcohol-water choice in three pairs of rat lines selectively bred for differences in alcohol preference. (2009 Mar)Timberlake WAlcohol
8698472Influence of smoking and race on immunoglobulin G subclass concentrations in early-onset periodontitis patients. (1996 Jul)Quinn SMInfect Immun
267481051-Adamantylamine a simple urine marker for screening for third generation adamantyl-type synthetic cannabinoids by ultra-performance liquid chromatography tandem mass spectrometry. (2016 Nov)Ford LTAnn Clin Biochem
19322167Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system. (2009 Aug)Cannella NNeuropsychopharmacology
19860802Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats. (2010 Jan)Ruggeri BAlcohol Clin Exp Res
25023357Identification of two clinical hepatocellular carcinoma patient phenotypes from results of standard screening parameters. (2014 Jun)Carr BISemin Oncol
22982682Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats. (2012 Dec)Schmoutz CDPharmacol Biochem Behav
29488437Investigating the relationship between plasma neuropeptide-S levels and clinical depression. (2018 Feb 28)Baykan HNord J Psychiatry
23149909Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat. (2013 Mar)Kallupi MPsychopharmacology (Berl)
24170639Low-density lipoprotein cholesterol control rates in the type-2 diabetic patient population within independent nurse practitioner settings. (2013 Aug)Gray KJ Am Assoc Nurse Pract
24723498Cardio-adipose tissue cross-talk: relationship between adiponectin, plasma pro brain natriuretic peptide and incident heart failure. (2014 Jun)Lindberg SEur J Heart Fail
24170653Therapeutic options for lowering LDL-C in type 2 diabetes: a nurse practitioner's perspective. (2013 Sep)Lew KNJ Am Assoc Nurse Pract
28302012Targeting NPY, CRF/UCNs and NPS Neuropeptide Systems to Treat Alcohol Use Disorder (AUD). (2017)Rodriguez FDCurr Med Chem
22739468Chronic ethanol potentiates the effect of neuropeptide s in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects. (2012 Oct)Enquist JNeuropsychopharmacology
24245839Neighborhood problems and nocturnal blood pressure dipping. (2014 Nov)Euteneuer FHealth Psychol
25653234Nanoparticles increase the efficacy of cancer chemopreventive agents in cells exposed to cigarette smoke condensate. (2015 Mar)Pulliero ACarcinogenesis
20739649Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. (2010 Aug 31)Matsuzaki TNeurology
25220242Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats. (2014 Nov 15)Bonano JSEur J Pharmacol
12657373Cardiac structure and function after short-term ethanol consumption in rats. (2003 Jan)Kim SDAlcohol
24431189Nasal polyp chitinolytic activity associated with smoking or allergy. (2014 May)Heo KWInt Forum Allergy Rhinol