Gene: RECQL

5965
RECQL1|RecQ1
RecQ like helicase
protein-coding
12p12.1
Ensembl:ENSG00000004700 MIM:600537 Vega:OTTHUMG00000169131 UniprotKB:P46063
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.632e-1 (AD)  3.345e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAM90.845
SCAF110.842
AQR0.831
BTAF10.83
DDX210.83
HIPK30.826
TRAM10.824
CALU0.82
KLHL200.819
CTTNBP2NL0.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.383
OR4F29-0.371
FAM186A-0.305
ARSF-0.296
HES5-0.293
NANOS3-0.279
ASPDH-0.277
C19orf73-0.25
NEU4-0.242
BTBD17-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RECQL mRNA"16269432
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RECQL mRNA"28903501
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of RECQL mRNA"19031421
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of RECQL mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RECQL mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of RECQL mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of RECQL mRNA17585979
D020106AcrylamideAcrylamide results in increased expression of RECQL mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RECQL protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RECQL gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of RECQL mRNA"23195993
D000447AldehydesAldehydes results in decreased expression of RECQL mRNA25014914
D001151ArsenicArsenic affects the methylation of RECQL gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of RECQL mRNA]"19446018
C547126AZM551248AZM551248 results in decreased expression of RECQL mRNA22323515
D001554BenzeneBenzene affects the expression of RECQL mRNA16188086
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RECQL mRNA"20018196
D004958EstradiolEstradiol affects the expression of RECQL mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of RECQL mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RECQL gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RECQL mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of RECQL mRNA26079696
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RECQL mRNA17602206
D003042CocaineCocaine affects the expression of RECQL mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of RECQL mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of RECQL mRNA21878529
D016572CyclosporineCyclosporine affects the expression of RECQL mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of RECQL mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RECQL mRNA17602206
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RECQL protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RECQL mRNA17942748
D005485FlutamideFlutamide results in increased expression of RECQL mRNA24136188
D005897GlafenineGlafenine results in increased expression of RECQL mRNA24136188
D017313FenretinideFenretinide results in decreased expression of RECQL mRNA28973697
D007649KetamineKetamine results in decreased expression of RECQL mRNA20080153
C011890kojic acidkojic acid results in decreased expression of RECQL mRNA16595896
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RECQL mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RECQL mRNA23649840
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RECQL mRNA22401849
D009532NickelNickel results in decreased expression of RECQL mRNA23195993
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of RECQL mRNA19074003
C046012pentanalpentanal results in decreased expression of RECQL mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of RECQL mRNA27153767
D010894PiroxicamPiroxicam results in decreased expression of RECQL mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of RECQL mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of RECQL mRNA26079696
D011794QuercetinQuercetin results in increased expression of RECQL mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of RECQL mRNA19244175
D012643SeleniumSelenium results in decreased expression of RECQL mRNA19244175
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of RECQL mRNA15601916
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of RECQL mRNA19074003
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RECQL mRNA17942748
D013853ThioacetamideThioacetamide results in increased expression of RECQL mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of RECQL mRNA17656681
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of RECQL mRNA"17951470
D014635Valproic AcidValproic Acid results in increased expression of RECQL mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RECQL gene25560391
C025643vinclozolinvinclozolin results in decreased expression of RECQL mRNA23555832
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of RECQL mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of RECQL mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003678DNA helicase activity-IDA11562355  
GO:0004003ATP-dependent DNA helicase activity-TAS7961977  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI9168958  15886194  23396353  
GO:0005524ATP binding-IEA-  
GO:0009378four-way junction helicase activity-IBA21873635  
GO:0036310annealing helicase activity-IBA21873635  
GO:0036310annealing helicase activity-IDA19177149  
GO:0043140ATP-dependent 3'-5' DNA helicase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IBA21873635  
GO:0000733DNA strand renaturation-IDA19177149  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-TAS7961977  
GO:0006310DNA recombination-IBA21873635  
GO:0032508DNA duplex unwinding-IBA21873635  
GO:0032508DNA duplex unwinding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005694chromosome-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147782DNA repair gene polymorphisms and risk of pancreatic cancer. (2009 Jan 15)Li DClin Cancer Res