Gene: REL

5966
C-Rel
REL proto-oncogene, NF-kB subunit
protein-coding
2p16.1
Ensembl:ENSG00000162924 MIM:164910 Vega:OTTHUMG00000129418 UniprotKB:Q04864
NC_000002.12
PubMed
0   ANCO-SNPs
CD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.486e-1 (AD)  8.354e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTTNBP2NL0.719
B3GNT50.708
KDM5A0.707
SLC4A70.704
DSE0.702
ANKRD440.699
ZNF810.698
KLHL60.695
TNFRSF10A0.691
ZNF2640.687

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.303
NANOS3-0.302
GSG1-0.284
ZSCAN1-0.282
FBLL1-0.281
CDT1-0.271
TEX29-0.268
HAGHL-0.264
ALG1L-0.263
SLC27A5-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4172072,2',4,6,6'-pentachlorobiphenyl"2,2',4,6,6'-pentachlorobiphenyl results in increased activity of REL protein"16611624
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [REL protein binds to NFKB1 protein]21173233
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of REL mRNA"21703328
C0038982-anisidine2-anisidine affects the expression of REL mRNA28089782
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of REL mRNA16014739
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]"23452621
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of REL protein]"15772366
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of REL mRNA12419474
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of REL mRNA]"26546572
D000082AcetaminophenAcetaminophen affects the expression of REL mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of REL mRNA24449571
D001151ArsenicArsenic results in decreased expression of REL mRNA27838757
C006632arsenic trioxidearsenic trioxide results in decreased expression of REL protein18349030
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
D001507BeclomethasoneBeclomethasone results in increased expression of REL mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of REL mRNA28651000
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of REL mRNA18192240
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]23114885
C006780bisphenol Abisphenol A affects the expression of REL mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of REL promoter27334623
C006780bisphenol Abisphenol A affects the expression of REL mRNA21786754
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852|1243305
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of REL mRNA12419474
D002248Carbon Monoxide[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]11880364
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of REL protein15978749
D002330CarmustineCarmustine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852|1243305
C503589cis-9, trans-11-conjugated linoleic acid"cis-9, trans-11-conjugated linoleic acid affects the activity of REL protein"17327424
D003042CocaineCocaine affects the expression of REL protein16179556
D003042CocaineCocaine results in decreased activity of REL protein20477932
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D003609Dactinomycin[RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]11880364
D003703DemecolcineDemecolcine results in increased expression of REL mRNA23649840
C007262deoxynivalenol"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of REL protein]"15772366
C007262deoxynivalenoldeoxynivalenol affects the localization of REL protein12604842
C007262deoxynivalenoldeoxynivalenol results in decreased activity of [REL protein binds to NFKB1 protein]8887449
C007262deoxynivalenoldeoxynivalenol results in increased activity of REL protein15772366
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of REL mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of REL mRNA27392435
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of REL mRNA]"26546572
D002945CisplatinCisplatin results in increased expression of REL mRNA26546572
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of REL protein27589886
D004041Dietary FatsDietary Fats results in decreased expression of REL mRNA18042831
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to NFKB1 protein] which binds to IL6 promoter]]"14678569
D004147DioxinsDioxins affects the expression of REL mRNA20463971
D004317DoxorubicinDoxorubicin affects the localization of REL protein15870702
D004317DoxorubicinDoxorubicin results in decreased expression of REL mRNA16404146
D004317DoxorubicinREL protein affects the susceptibility to Doxorubicin17890907
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of REL mRNA19118595
D005033EthylmaleimideEthylmaleimide results in decreased phosphorylation of REL protein11085954
D005557FormaldehydeFormaldehyde results in decreased expression of REL mRNA20655997
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of REL mRNA12400877
C007789fucoidanfucoidan results in decreased activity of REL protein16201850
C056507gemcitabinegemcitabine results in decreased expression of REL protein20940707
C056507gemcitabinesulforafan promotes the reaction [gemcitabine results in decreased expression of REL protein]20940707
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D017313FenretinideFenretinide results in decreased expression of REL mRNA28973697
D017313FenretinideFenretinide results in increased expression of REL mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased localization of REL protein16249388
D006861Hydrogen PeroxideTrifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]16249388
C082359imidaclopridREL protein affects the susceptibility to imidacloprid28578396
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of REL mRNA27392435
C544151jinfukangjinfukang results in decreased expression of REL mRNA27392435
C008261lead acetatelead acetate results in increased expression of REL mRNA24260418
C050016lipoarabinomannanlipoarabinomannan results in decreased localization of and results in decreased activity of REL protein16263713
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of REL mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of REL mRNA"18930950
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of REL mRNA9122163
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of REL mRNA23724058
D008070Lipopolysaccharides[Nickel co-treated with Lipopolysaccharides] affects the localization of REL protein22287454
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]23724058
D008070Lipopolysaccharides"9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to NFKB1 protein] which binds to IL6 promoter]]"14678569
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [[REL protein binds to NFKB1 protein] which binds to IL6 promoter]14678569
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of and results in increased localization of REL protein10188978|1915968
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of REL mRNA10975854|1205791
D008070LipopolysaccharidesLithium promotes the reaction [Lipopolysaccharides results in increased localization of REL protein]19159680
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]20423518
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased localization of REL protein]10188978
D008070LipopolysaccharidesAcetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852
D008070LipopolysaccharidesButhionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852|1243305
D008070LipopolysaccharidesCarmustine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852|1243305
D008070LipopolysaccharidesLipopolysaccharides affects the localization of REL protein11970852|1243305
D008070Lipopolysaccharidespyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852
D008094LithiumLithium promotes the reaction [Lipopolysaccharides results in increased localization of REL protein]19159680
D009532Nickel[Nickel co-treated with Lipopolysaccharides] affects the localization of REL protein22287454
C029938nickel sulfatenickel sulfate results in decreased expression of REL mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of REL mRNA16780908
D009638NorepinephrineAcetylcysteine inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D009638NorepinephrineAscorbic Acid inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]23114885
D009638NorepinephrineNorepinephrine affects the localization of REL protein23114885
D009638NorepinephrineNorepinephrine promotes the reaction [REL protein binds to F3 promoter]23114885
D009638NorepinephrineNorepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]23114885
D009638Norepinephrineprolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D009638NorepinephrineREL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]23114885
D009638NorepinephrineREL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]23114885
D009638NorepinephrineVitamin E inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D009638Norepinephrinewortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D009638Norepinephrinewortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]23114885
D009761NystatinNystatin results in increased activity of REL protein16374455
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of REL mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D000073878Palm OilPalm Oil results in decreased expression of REL mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of REL mRNA27153767
D010575PesticidesPesticides results in decreased methylation of REL gene28396702
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]23724058
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]20423518
C008922piperinepiperine results in decreased localization of REL protein15531295
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
D011374ProgesteroneProgesterone promotes the reaction [HLTF protein binds to REL protein]18631131
D011374ProgesteroneProgesterone promotes the reaction [[HLTF protein co-treated with REL protein co-treated with EGR1 protein] binds to HLTF promoter]18631131
D011374ProgesteroneREL protein inhibits the reaction [Progesterone results in increased expression of HLTF mRNA]18631131
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased activity of [REL protein binds to NFKB1 protein]21173233
C526689punarnavinepunarnavine results in decreased localization of REL protein20192578
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]11970852
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]23452621
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased localization of REL protein]10188978
D015474IsotretinoinIsotretinoin affects the localization of and results in decreased activity of REL protein18652567|1906612
D019438RitonavirRitonavir results in decreased activity of REL protein16174765
C018145scoparonescoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein]16376386
D012822Silicon DioxideSilicon Dioxide results in increased expression of REL mRNA19073995
C017947sodium arsenitesodium arsenite results in increased expression of REL mRNA16014739
D012969Sodium FluorideSodium Fluoride results in decreased expression of REL protein28918527
D013311StreptozocinStreptozocin affects the localization of and results in increased activity of REL protein19002579
C016766sulforafansulforafan promotes the reaction [gemcitabine results in decreased expression of REL protein]20940707
C016766sulforafansulforafan results in decreased expression of REL protein20940707
D016559TacrolimusTacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of REL protein]18172213
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of REL mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of REL mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of REL mRNA12377990
D013749TetrachlorodibenzodioxinTacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of REL protein]18172213
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of REL mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of REL protein18172213
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [TNF protein results in increased localization of REL protein]12181450
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of REL mRNA22298810
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of REL mRNA9122163
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]15477007
D013755Tetradecanoylphorbol Acetatescoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein]16376386
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of REL protein16376386
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA25613284
C483909torcetrapibtorcetrapib results in increased expression of REL mRNA23228038
D014212TretinoinTretinoin results in increased expression of REL mRNA16140955
D014268TrifluoperazineTrifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]16249388
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of REL mRNA"18930950
D014415TunicamycinTunicamycin results in increased expression of REL mRNA17127020
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of REL mRNA12400877
D014520UrethaneUrethane results in increased expression of REL mRNA12400877
D014635Valproic AcidValproic Acid results in decreased expression of REL mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of REL mRNA19101580
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of REL gene25560391
D014750VincristineVincristine results in increased expression of REL mRNA23649840
D014810Vitamin EVitamin E inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
D014810Vitamin EVitamin E affects the reaction [[REL binds to GCLC promoter] which affects the expression of GCLC mRNA]16298738
D014810Vitamin EVitamin E affects the reaction [[REL binds to GCLM promoter] which affects the expression of GCLM mRNA]16298738
C009687wortmanninwortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]23114885
C009687wortmanninwortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]23114885
D015215ZidovudineREL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]17138822

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IDA1406630  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IDA1406630  
GO:0003682chromatin binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-NAS8423996  
GO:0005515protein binding-IPI14743216  15799966  25416956  25609649  26496610  26972000  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006954inflammatory response-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0010629negative regulation of gene expression-IDA22065573  
GO:0032688negative regulation of interferon-beta production-IDA22065573  
GO:0034097response to cytokine-IBA21873635  
GO:0038061NIK/NF-kappaB signaling-IBA21873635  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0045087innate immune response-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA1406630  
GO:1901215negative regulation of neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IMP22065573  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0033256I-kappaB/NF-kappaB complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24489016Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis. (2014 Jun)Davis LARheumatology (Oxford)
15358439DHEAS and POMS measures identify cocaine dependence treatment outcome. (2005 Jan)Wilkins JNPsychoneuroendocrinology
23615073Vitamin C forestalls cigarette smoke induced NF-kappaB activation in alveolar epithelial cells. (2013 Jun 20)Das BToxicol Lett
25514196Comprehensive analysis of genes, pathways, and TFs in nonsmoking Taiwan females with lung cancer. (2015 Mar)Lv MExp Lung Res