Gene info: ID 5972

Gene: REN

GENE ID: 5972

Synonyms: HNFJ2

Description: renin

Gene type: protein-coding

Location: 1q32.1

dbXrefs: Ensembl:ENSG00000143839 MIM:179820 Vega:OTTHUMG00000036059 UniprotKB:P00797

RefSeq: NG_012122.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.481e-1 (AD) 2.228e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HPDL	0.578
ARSF	0.568
HES5	0.566
SLC13A5	0.541
PYGM	0.536
BTBD17	0.522
ACY1	0.522
SLC7A10	0.52
FAM69C	0.518
PIPOX	0.517

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HLA-DQB1	-0.374
SMCO4	-0.368
ZNF845	-0.359
ACAN	-0.358
RASEF	-0.356
CP	-0.354
TIFA	-0.351
SLA	-0.343
VSIG4	-0.343
HSD11B2	-0.341

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00212	Remikiren	Small Molecule	126222-34-2	Approved	Target
DB00350	Minoxidil	Small Molecule	38304-91-5	Approved\|Investigational	Target
DB01844	N,N-dimethylformamide	Small Molecule	68-12-2	Experimental	Target
DB02296	1-Hydroxy-3-Methylbutane	Small Molecule		Experimental	Target
DB02803	3-Phenyl-1,2-Propandiol	Small Molecule		Experimental	Target
DB03024	2-Methyl-3-(2-Aminothiazolo)Propanal	Small Molecule		Experimental	Target
DB03395	Enalkiren	Small Molecule	113082-98-7	Experimental	Target
DB03736	2-Cyclopropylmethylenepropanal	Small Molecule		Experimental	Target
DB03968	1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine	Small Molecule		Experimental	Target
DB04379	N-Methyl-N-(Methylbenzyl)Formamide	Small Molecule		Experimental	Target
DB04387	1-Hydroxy-2-Amino-3-Cyclohexylpropane	Small Molecule		Experimental	Target
DB05203	SPP1148	Small Molecule	-	Investigational	Target
DB06899	N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE	Small Molecule		Experimental	Target
DB06967	6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB07059	N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE	Small Molecule		Experimental	Target
DB07113	(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE	Small Molecule		Experimental	Target
DB07174	6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE	Small Molecule		Experimental	Target
DB07244	5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB08099	6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine	Small Molecule	-	Experimental	Target
DB09026	Aliskiren	Small Molecule	173334-57-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of REN mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of REN mRNA"	19114083
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein	9300315
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]	9300315
C004504	2-bromoethylamine	2-bromoethylamine results in increased expression of REN protein	19463747
C076864	2-hexynyladenosine-5'-N-ethylcarboxamide	2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein	9300315
C076864	2-hexynyladenosine-5'-N-ethylcarboxamide	Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
C076864	2-hexynyladenosine-5'-N-ethylcarboxamide	spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
C585004	2-monochloropropanediol	2-monochloropropanediol results in increased expression of REN mRNA	28522335
C026708	2-phenylaminoadenosine	2-phenylaminoadenosine results in increased activity of REN protein	2203898
D000070	Acebutolol	Acebutolol results in decreased activity of REN protein	6118215
D000070	Acebutolol	Acebutolol results in decreased activity of REN protein	6110712
D000079	Acetaldehyde	[Acetaldehyde co-treated with Cyanamide] results in increased activity of REN protein	26298003
D000082	Acetaminophen	Acetaminophen results in increased activity of REN protein	1825077
D000082	Acetaminophen	Acetaminophen results in increased expression of REN protein	455818
D000082	Acetaminophen	ALB protein inhibits the reaction [Acetaminophen results in increased activity of REN protein]	1825077
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
D000241	Adenosine	Adenosine results in decreased secretion of REN protein	3044993
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of REN gene	27153756
D000420	Albuterol	Albuterol results in increased expression of REN protein	2829953
D000450	Aldosterone	[AGT co-treated with REN] results in increased abundance of Aldosterone	18679781
D000450	Aldosterone	candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
D000450	Aldosterone	Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
C446481	aliskiren	[aliskiren co-treated with Atenolol] results in decreased activity of REN protein	18957387
C446481	aliskiren	aliskiren results in decreased activity of REN protein	18957387
C446481	aliskiren	aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]	27645307
C446481	aliskiren	aliskiren results in decreased activity of REN protein	15662231\|1880278
D000526	Alprenolol	Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]	923630
D000526	Alprenolol	Alprenolol results in decreased expression of REN protein	923630
C001864	aluminum phosphide	aluminum phosphide results in increased activity of REN protein	2200784
D017311	Amlodipine	Amlodipine results in increased expression of REN protein	10218729
D017311	Amlodipine	[Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein	11078175
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of REN mRNA	16483693
D000666	Amphotericin B	Amphotericin B results in decreased secretion of REN protein	7391978
D019162	Anesthetics, Combined	"Anesthetics, Combined results in increased activity of REN protein"	453612\|7020487
D019162	Anesthetics, Combined	"Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]"	453612\|7020487
D019162	Anesthetics, Combined	"Propranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]"	7020487
D019162	Anesthetics, Combined	"Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]"	7020487
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	6257882
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein	6185789
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]	3326920
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	1647690\|3071592\|
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of and affects the activity of REN protein	7000102
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of and results in increased activity of REN protein	6105291
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN protein	1668233\|6168412\|
D000806	Angiotensin-Converting Enzyme Inhibitors	Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	3326920
D000806	Angiotensin-Converting Enzyme Inhibitors	AGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]	3078272
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	231700\|9140837\|9
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN mRNA	1330361\|9533614
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN protein	1330361\|9533614
D000806	Angiotensin-Converting Enzyme Inhibitors	Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	6753910
D000959	Antihypertensive Agents	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D001241	Aspirin	Aspirin results in decreased activity of REN protein	19805643\|7994448
D001262	Atenolol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D001262	Atenolol	[aliskiren co-treated with Atenolol] results in decreased activity of REN protein	18957387
D001262	Atenolol	Atenolol results in decreased activity of REN protein	18957387\|3333524
D001262	Atenolol	Atenolol results in decreased expression of REN protein	14639093
D001262	Atenolol	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D001262	Atenolol	Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]	9300315
D001262	Atenolol	Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
D001262	Atenolol	Atenolol results in decreased expression of REN protein	9300315
D001262	Atenolol	Atenolol results in decreased activity of REN protein	6756707
C044946	benazepril	[benazepril co-treated with Valsartan] results in increased activity of REN protein	10836730
C044946	benazepril	benazepril results in increased expression of REN protein	1316404
C044946	benazepril	[benazepril co-treated with Valsartan] results in increased activity of REN protein	11501062
C044946	benazepril	benazepril results in increased activity of REN protein	11501062
D001539	Bendroflumethiazide	Bendroflumethiazide results in increased expression of REN protein	62162
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of REN gene	28505145
C006780	bisphenol A	bisphenol A results in increased expression of REN mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of REN gene	28505145
C014926	BQ 22-708	BQ 22-708 results in increased activity of REN protein	7018762
D002034	Bumetanide	[Bumetanide co-treated with trandolapril] results in increased expression of REN protein	16635047
D002034	Bumetanide	Bumetanide results in increased expression of REN protein	16635047
D002034	Bumetanide	Bumetanide results in increased secretion of REN protein	7040495
D002034	Bumetanide	Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]	6756707
D002034	Bumetanide	Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]	7040495
D002034	Bumetanide	Bumetanide results in increased expression of REN mRNA	14504926
C084811	bunitrolol	bunitrolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6113146
D012368	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D012368	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in increased secretion of REN protein	9256163
C059042	BW 175	BW 175 binds to and results in decreased activity of REN protein	8149456
D002110	Caffeine	Caffeine results in increased activity of REN protein	8244516
D002110	Caffeine	Caffeine results in increased activity of REN protein	1860718\|3020089
D002110	Caffeine	Caffeine results in increased expression of REN protein	3044993
D002110	Caffeine	Caffeine results in increased secretion of REN protein	10803761
D002118	Calcium	Calcium results in decreased secretion of REN protein	9618396
D002118	Calcium	[[Calcium results in increased activity of MYLK protein] which results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein	9618396
D002118	Calcium	ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein]	9618396
C059041	calyculin A	calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]	9618396
C059041	calyculin A	[calyculin A results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein	9618396
C081643	candesartan	candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
C081643	candesartan	candesartan results in decreased activity of REN protein	18679781
C081643	candesartan	candesartan results in increased expression of REN mRNA	18796534\|1904758
C043211	carvedilol	carvedilol results in decreased expression of REN protein	2454358
C043211	carvedilol	carvedilol results in decreased activity of REN protein	1974513
C043211	carvedilol	carvedilol results in decreased expression of REN protein	2454359
D000068579	Celecoxib	Celecoxib results in decreased expression of REN protein	10742298
D002714	Chlorisondamine	Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D002752	Chlorthalidone	Chlorthalidone results in increased activity of REN protein	1116335\|3319646
D002752	Chlorthalidone	Chlorthalidone results in increased expression of REN protein modified form	796642
D017315	Cilazapril	Cilazapril results in increased activity of REN protein	2419701
D017315	Cilazapril	Cilazapril results in increased activity of REN protein	2425185
D003000	Clonidine	Clonidine results in decreased activity of REN protein	6991409
D003000	Clonidine	Clonidine results in decreased secretion of and results in decreased activity of REN protein	6248808
D003000	Clonidine	[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein	12014310
D003000	Clonidine	Clonidine results in decreased activity of REN protein	238481\|6337028\|9
D003000	Clonidine	Clonidine results in decreased expression of REN protein	20833658\|3913757
D003000	Clonidine	Clonidine results in increased activity of REN protein	3007707\|7837211
D005576	Colforsin	Colforsin results in increased expression of REN mRNA	9256163
D005576	Colforsin	Colforsin results in increased secretion of REN protein	9256163
D005576	Colforsin	"[Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein"	10432392
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased activity of REN protein"	1122661\|45830
D003471	Cuprizone	Cuprizone affects the expression of REN mRNA	27523638
D003484	Cyanamide	[Acetaldehyde co-treated with Cyanamide] results in increased activity of REN protein	26298003
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D016572	Cyclosporine	Cyclosporine affects the expression of REN protein	1851318
D016572	Cyclosporine	Cyclosporine results in decreased activity of REN protein	3300326
D016572	Cyclosporine	Cyclosporine results in increased expression of REN mRNA	21865292
D016572	Cyclosporine	Cyclosporine results in increased expression of REN protein	21865292\|7532090
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
C053562	desflurane	[Propofol co-treated with desflurane] results in increased expression of REN protein	8017643
D003907	Dexamethasone	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D003907	Dexamethasone	Dexamethasone results in increased activity of REN protein	174842
D003907	Dexamethasone	Dexamethasone results in increased secretion of REN protein	3074918
D003994	Bucladesine	Bucladesine results in increased expression of REN mRNA	9256163
D003994	Bucladesine	Bucladesine results in increased secretion of REN protein	9256163
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of REN mRNA	26924002
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of REN protein	22677342
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased activity of REN protein	45830
D004078	Dihydralazine	Dihydralazine results in increased activity of REN protein	3383316
D002117	Calcitriol	Calcitriol results in decreased activity of REN protein	10052739
D004110	Diltiazem	Diltiazem results in increased expression of REN protein	2222951
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of REN mRNA	26924002
D004232	Diuretics	Diuretics results in increased expression of REN protein	62162
D004280	Dobutamine	Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D004280	Dobutamine	Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]	9203624
D004280	Dobutamine	Dobutamine results in increased activity of REN protein	9209250
D004280	Dobutamine	Dobutamine results in increased expression of REN mRNA	9203624
D004280	Dobutamine	Dobutamine results in increased secretion of REN protein	9203624
D017292	Doxazosin	Doxazosin results in increased expression of REN protein	7818152
D004656	Enalapril	[Enalapril co-treated with FR 173657] results in increased activity of REN protein	12019275
D004656	Enalapril	Enalapril results in increased activity of REN protein	12019275
D004656	Enalapril	Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]	18679781
D004656	Enalapril	Enalapril results in decreased activity of REN protein	18679781
D004656	Enalapril	Enalapril results in increased expression of REN protein	2994932
D004656	Enalapril	[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein	11078175
D004656	Enalapril	Enalapril results in increased expression of REN mRNA	19536436\|1976787
D004656	Enalapril	Enalapril results in increased expression of REN protein	19536436\|1976787
D004656	Enalapril	Enalapril results in increased secretion of REN protein	19109587\|1953643
D004656	Enalapril	GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]	19109587
D004656	Enalapril	GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]	19109587
D004656	Enalapril	REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]	17846348
D004656	Enalapril	[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA	17846348
D004656	Enalapril	Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]	19536436
D004656	Enalapril	Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]	19536436
D004656	Enalapril	Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]	19536436
D004656	Enalapril	Enalapril results in increased activity of REN protein	6094050
D004656	Enalapril	Enalapril results in increased expression of REN mRNA	12434137\|1330361
D004656	Enalapril	Enalapril results in increased expression of REN protein	12434137\|1330361
D015773	Enalaprilat	Enalaprilat results in increased expression of REN mRNA	21795644
D004837	Epinephrine	Epinephrine results in increased activity of REN protein	6314140\|8592096
D004837	Epinephrine	ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein]	6314140
C036604	esmolol	esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	2569849
D004967	Estrogens	Estrogens results in decreased expression of REN protein	185040
D004966	Estrogens, Conjugated (USP)	"Estrogens, Conjugated (USP) results in increased activity of REN protein"	45830
D000431	Ethanol	Ethanol results in increased activity of REN protein	22982071
D000431	Ethanol	Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]	22982071
D004997	Ethinyl Estradiol	AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased activity of REN protein]	11095476
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased activity of REN protein	11095476
D004997	Ethinyl Estradiol	Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]	11095476
D005280	Fenoterol	Fenoterol results in increased activity of REN protein	9209250
D005280	Fenoterol	Fenoterol results in increased expression of REN protein	2829953
D005283	Fentanyl	[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein	3284271
C105311	FR 173657	[Enalapril co-treated with FR 173657] results in increased activity of REN protein	12019275
D005665	Furosemide	Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]	11095476
D005665	Furosemide	Furosemide results in increased activity of REN protein	11046100\|1924052
D005665	Furosemide	Furosemide results in increased expression of REN protein	3530574\|4028619
D005665	Furosemide	Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]	3530574\|4028619
D005665	Furosemide	Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]	1924052
D005665	Furosemide	Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]	4028619
D005665	Furosemide	Furosemide results in increased expression of REN mRNA	15976003
D005665	Furosemide	Furosemide results in increased expression of REN protein	15976003
D005665	Furosemide	PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]	15976003
D005665	Furosemide	PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]	15976003
D005665	Furosemide	Furosemide results in increased activity of REN protein	10604960\|1113505
D005665	Furosemide	Furosemide results in increased expression of REN mRNA	11135058\|8418022
D005665	Furosemide	Furosemide results in increased expression of REN protein	7954537
D005665	Furosemide	Furosemide results in increased secretion of REN protein	8418022
D005665	Furosemide	Furosemide results in increased activity of REN protein	3893163
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of REN gene	28505145
D019833	Genistein	Genistein inhibits the reaction [EGF protein results in decreased secretion of REN protein]	8491500
D005839	Gentamicins	Gentamicins results in increased expression of REN protein	8160791
D005947	Glucose	Glucose results in increased expression of REN mRNA	19861503
D005947	Glucose	Glucose results in increased expression of REN protein	19861503
C004312	glycidol	glycidol results in decreased expression of REN mRNA	24915197
D006034	Glycyrrhetinic Acid	Glycyrrhetinic Acid results in decreased activity of REN protein	20460744
D019695	Glycyrrhizic Acid	Glycyrrhizic Acid results in decreased activity of REN protein	20460744
D016316	Guanfacine	Guanfacine results in decreased activity of REN protein	1305723\|3520085
D006221	Halothane	[Halothane co-treated with Nitroprusside] results in increased activity of REN protein	3281763
D006830	Hydralazine	Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]	923630
D006830	Hydralazine	Hydralazine results in increased activity of REN protein	3154321
D006830	Hydralazine	Hydralazine results in increased expression of REN protein	2953239\|923630
D006830	Hydralazine	Hydralazine results in increased activity of REN protein	2203898\|231700
D006852	Hydrochlorothiazide	Hydrochlorothiazide results in increased activity of REN protein	1930859\|2920503
D006852	Hydrochlorothiazide	Hydrochlorothiazide results in increased expression of REN protein	12569265
D006852	Hydrochlorothiazide	Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]	12569265
D006852	Hydrochlorothiazide	Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]	1930859
D006852	Hydrochlorothiazide	Hydrochlorothiazide results in increased activity of REN protein	11135058
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of REN protein	15743397\|7473517
D003900	Desoxycorticosterone	[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein	11039
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of REN protein]	28578904
C026777	ICI 118551	ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein]	6314140
D007190	Indapamide	Indapamide results in increased expression of REN protein	6578003
D007200	Indican	Indican results in increased expression of REN mRNA	25056788
D007213	Indomethacin	[Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein	11078175
D007213	Indomethacin	[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein	11078175
D007213	Indomethacin	Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]	6756707
D007213	Indomethacin	Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]	3530574\|4028619
D007213	Indomethacin	Indomethacin results in decreased activity of REN protein	3884224\|7035040\|
D007213	Indomethacin	Indomethacin results in decreased expression of and results in decreased activity of REN protein	6756707
D007213	Indomethacin	Indomethacin results in decreased expression of REN protein	119300\|3530574\|4
D007213	Indomethacin	[Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein	7049707
D007213	Indomethacin	aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]	27645307
D007213	Indomethacin	Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	6753910
D007213	Indomethacin	Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D007213	Indomethacin	Indomethacin results in decreased activity of REN protein	439781
D007213	Indomethacin	Indomethacin results in increased expression of REN protein	27645307
C002587	ioxitalamic acid	Acetylcysteine inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
C002587	ioxitalamic acid	ioxitalamic acid results in increased expression of REN protein	19945959
C002587	ioxitalamic acid	Propranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
C081309	irbesartan	irbesartan results in increased expression of REN protein	14639093
D015056	1-Methyl-3-isobutylxanthine	"[Sodium, Dietary deficiency results in increased susceptibility to 1-Methyl-3-isobutylxanthine] which results in increased secretion of REN protein"	10432392
D007530	Isoflurane	[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein	3284271
D007530	Isoflurane	Isoflurane affects the activity of REN protein	3281763
D007530	Isoflurane	[Labetalol co-treated with Isoflurane] results in increased expression of REN protein	1897344
D007545	Isoproterenol	Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	Isoproterenol results in increased activity of REN protein	6103674
D007545	Isoproterenol	Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D007545	Isoproterenol	Isoproterenol results in increased activity of REN protein	6314140
D007545	Isoproterenol	Isoproterenol results in increased expression of REN protein	1653766
D007545	Isoproterenol	Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein]	1653766
D007545	Isoproterenol	Isoproterenol promotes the reaction [CD38 gene mutant form results in increased activity of REN protein]	23343681
D007545	Isoproterenol	Isoproterenol results in increased expression of REN mRNA	21424707
D007545	Isoproterenol	Isoproterenol results in increased secretion of REN protein	3515047
D007545	Isoproterenol	"[Sodium, Dietary deficiency results in increased susceptibility to Isoproterenol] which results in increased secretion of REN protein"	10432392
D007545	Isoproterenol	Isoproterenol results in increased expression of REN protein	11709406\|9539862
D007545	Isoproterenol	Isoproterenol results in increased secretion of REN protein	3910304
D007545	Isoproterenol	Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D007545	Isoproterenol	quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D007545	Isoproterenol	Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]	9539862
D007545	Isoproterenol	Isoproterenol results in increased activity of REN protein	7804848
D007556	Isoxsuprine	Isoxsuprine results in increased activity of REN protein	31167
D017275	Isradipine	Isradipine results in increased activity of REN protein	2550243
D007649	Ketamine	Ketamine results in increased expression of REN protein	6349867
D007654	Ketoconazole	Ketoconazole results in decreased expression of REN protein	2632720
D007660	Ketoprofen	Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]	1924052
D007741	Labetalol	[Labetalol co-treated with Isoflurane] results in increased expression of REN protein	1897344
D007741	Labetalol	Labetalol results in decreased activity of REN protein	2524958\|7013770\|
D008070	Lipopolysaccharides	[IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D017706	Lisinopril	Lisinopril results in increased expression of REN protein	2550029
D017706	Lisinopril	Lisinopril results in increased expression of REN mRNA	8915971
D019808	Losartan	Losartan results in increased expression of REN protein	10483973
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]	28578904
D019808	Losartan	Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]	12569265
D019808	Losartan	[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein	9124547
D019808	Losartan	Losartan results in increased activity of REN protein	7965263\|8403307
D019808	Losartan	Losartan results in increased expression of REN protein	8423551
D019808	Losartan	Losartan results in increased expression of REN protein	9245700
D019808	Losartan	Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]	22982071
D019808	Losartan	Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
D019808	Losartan	Losartan results in increased activity of REN protein	9431853
D019808	Losartan	Losartan results in increased expression of REN mRNA	9431853\|9533614
D019808	Losartan	Losartan results in increased expression of REN protein	12013499\|1387008
C066026	losartan carboxylic acid	losartan carboxylic acid results in increased expression of REN protein	10483973
D008278	Magnesium Sulfate	Magnesium Sulfate results in increased activity of REN protein	1874207
D008469	Meclofenamic Acid	Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
C545385	Mequindox	Mequindox affects the expression of REN mRNA	20553828
D008731	Methoxychlor	Methoxychlor results in increased methylation of REN gene	23303685
D008750	Methyldopa	Methyldopa results in decreased activity of REN protein	145319
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of REN mRNA	23179753
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of REN protein	26612503
D008775	Methylprednisolone	Methylprednisolone results in increased activity of REN protein	235222\|6277579
D008775	Methylprednisolone	Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]	235222
D008790	Metoprolol	Metoprolol results in decreased expression of REN protein	2454358
D008790	Metoprolol	Metoprolol results in decreased expression of REN mRNA	8203557
D008914	Minoxidil	Minoxidil affects the expression of REN protein	28811
D008914	Minoxidil	Minoxidil binds to and results in decreased activity of REN protein	790007
D008914	Minoxidil	Minoxidil results in increased activity of REN protein	145319
D008914	Minoxidil	Minoxidil results in increased expression of REN protein	8238566
C070571	ML 7	calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]	9618396
C070571	ML 7	ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein]	9618396
C070571	ML 7	[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein	9618396
C070571	ML 7	ML 7 results in increased secretion of REN protein	9618396
C470272	momordin II (Oleanolic Acid)	momordin II (Oleanolic Acid) results in decreased activity of REN protein	20460744
C408362	momordin I (Oleanolic Acid)	momordin I (Oleanolic Acid) results in decreased activity of REN protein	20460744
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of REN mRNA	26924002
D009270	Naloxone	Naloxone results in increased activity of REN protein	3157294
D009288	Naproxen	Naproxen results in decreased activity of REN protein	2203262
D000068577	Nebivolol	Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein]	12806161
D009529	Nicardipine	Nicardipine results in increased activity of REN protein	1867428
D009543	Nifedipine	Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]	3326920
D009543	Nifedipine	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	3142437
D009543	Nifedipine	Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	3326920
D009543	Nifedipine	Nifedipine results in increased activity of REN protein	3326920\|6184561\|
D009543	Nifedipine	Nifedipine results in increased expression of REN protein	3313686
D009543	Nifedipine	Nifedipine results in increased activity of REN protein	3544790
C035100	nilvadipine	nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]	7533848
D009568	Nitrendipine	Nitrendipine results in increased activity of REN protein	2869952\|6734029
D009569	Nitric Oxide	Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein]	12806161
D009569	Nitric Oxide	"[Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein"	7541960
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of REN protein	10679504\|1512354
C007350	nitrofen	nitrofen results in decreased expression of REN mRNA	16292651
D005996	Nitroglycerin	Nitroglycerin results in decreased activity of REN protein	8640982
D005996	Nitroglycerin	Nitroglycerin results in increased activity of REN protein	9527094
D009599	Nitroprusside	Nitroprusside results in increased activity of REN protein	2434793\|6399253
D009599	Nitroprusside	bunitrolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6113146
D009599	Nitroprusside	esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	2569849
D009599	Nitroprusside	[Halothane co-treated with Nitroprusside] results in increased activity of REN protein	3281763
D009599	Nitroprusside	"Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]"	453612\|7020487
D009599	Nitroprusside	Nitroprusside results in increased activity of REN protein	1867428\|2413294\|
D009599	Nitroprusside	"Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]"	7020487
D009599	Nitroprusside	Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6434220
D009599	Nitroprusside	Nitroprusside affects the reaction [Sodium affects the activity of REN protein]	7009830
D009638	Norepinephrine	Norepinephrine results in increased activity of REN protein	8952593
D010096	Oxprenolol	[Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein	7049707
D010096	Oxprenolol	Oxprenolol results in decreased activity of REN protein	6173514\|6344036\|
D010424	Pentobarbital	Pentobarbital results in increased activity of REN protein	6348358
D010424	Pentobarbital	Pentobarbital results in increased activity of REN protein	3512818
D020913	Perindopril	Perindopril results in increased activity of REN protein	2549899\|2605800
D020913	Perindopril	Perindopril results in increased expression of REN protein	9383173
D015232	Dinoprostone	Dinoprostone results in increased expression of REN protein	495730
D015232	Dinoprostone	"[Sodium, Dietary deficiency results in increased susceptibility to Dinoprostone] which results in increased secretion of REN protein"	10432392
D010646	Phentolamine	Phentolamine results in increased activity of REN protein	6173514
D010656	Phenylephrine	Phenylephrine results in increased secretion of REN protein	6347479
D010656	Phenylephrine	Phenylephrine results in decreased activity of REN protein	2847676
D010869	Pindolol	Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D010869	Pindolol	Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]	7104148
D010869	Pindolol	Pindolol results in decreased activity of REN protein	791319
D010869	Pindolol	Pindolol results in decreased expression of REN protein	973972
D010880	Piperidines	Piperidines analog results in decreased activity of REN protein	18679781
D010936	Plant Extracts	Plant Extracts results in decreased expression of REN mRNA	23557933
D011217	Practolol	Practolol results in decreased activity of REN protein	6110712
D011224	Prazosin	Prazosin results in decreased activity of REN protein	7023672
D011224	Prazosin	Prazosin results in increased activity of REN protein	6173514\|6258839\|
D011224	Prazosin	Prazosin results in increased transport of REN protein	3539430
D011224	Prazosin	Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]	3539430
D011339	Probenecid	Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]	7040495
D015742	Propofol	[Propofol co-treated with desflurane] results in increased expression of REN protein	8017643
D011433	Propranolol	Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D011433	Propranolol	Propranolol results in decreased activity of REN protein	2566282
D011433	Propranolol	"Propranolol affects the reaction [Anesthetics, Combined results in increased activity of REN protein]"	7020487
D011433	Propranolol	"Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]"	7020487
D011433	Propranolol	Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein]	1653766
D011433	Propranolol	Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]	6434220
D011433	Propranolol	Propranolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]	7104148
D011433	Propranolol	Propranolol results in decreased activity of REN protein	1103606\|6346849\|
D011433	Propranolol	Propranolol results in decreased expression of REN protein	200433\|653302
D011433	Propranolol	Propranolol inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]	19945959
D011433	Propranolol	Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]	3539430
D011433	Propranolol	Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D011433	Propranolol	Propranolol results in decreased activity of REN protein	145319\|6110712
D000527	Alprostadil	Alprostadil results in increased expression of REN protein	9195357
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein	8446257
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of REN protein	9171944
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN protein	2236972
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of REN protein	2267444
D011794	Quercetin	Quercetin inhibits the reaction [EGF protein results in decreased secretion of REN protein]	8491500
C041125	quinapril	quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]	11709406
C041125	quinapril	quinapril results in increased expression of REN protein	10334802
D017257	Ramipril	Ramipril results in increased activity of REN protein	1327051
D017257	Ramipril	Ramipril results in increased expression of REN mRNA	14504926
D017257	Ramipril	Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]	9539862
D017257	Ramipril	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]	11832429
D017257	Ramipril	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]	11832429
D017257	Ramipril	Ramipril results in increased expression of REN protein	9179393
D011899	Ranitidine	Ranitidine affects the activity of REN protein	1972605
C074679	reboxetine	reboxetine results in decreased activity of REN protein	16717144
C065581	remikiren	remikiren results in decreased activity of REN protein	15662231
C013672	riddelliine	riddelliine results in increased expression of REN mRNA	18047727
C032302	rilmenidine	rilmenidine results in decreased activity of REN protein	2866274
D012312	Ritodrine	Ritodrine results in increased activity of REN protein	31167
D000068677	Sildenafil Citrate	Sildenafil Citrate results in increased activity of REN protein	15613622
D012834	Silver	Silver results in decreased expression of REN mRNA	26277626
D020123	Sirolimus	Sirolimus results in increased expression of REN mRNA	21865292
D012964	Sodium	Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]	1930859
D012964	Sodium	Sodium deficiency results in increased activity of REN protein	11299228
D012964	Sodium	Sodium deficiency results in increased expression of REN mRNA	19767874
D012964	Sodium	Sodium deficiency results in increased expression of REN protein	19767874
D012964	Sodium	Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]	19536436
D012964	Sodium	Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]	19536436
D012964	Sodium	Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]	19536436
D012964	Sodium	Sodium results in decreased expression of REN mRNA	19536436
D012964	Sodium	Sodium results in decreased expression of REN protein	19536436
D012964	Sodium	Sodium results in decreased secretion of REN protein	19536436
D012964	Sodium	Nitroprusside affects the reaction [Sodium affects the activity of REN protein]	7009830
D012964	Sodium	Sodium affects the activity of REN protein	7009830
D012964	Sodium	Sodium affects the expression of REN mRNA	12424424
D012965	Sodium Chloride	GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]	19474190
D012965	Sodium Chloride	REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]	17846348
D012965	Sodium Chloride	[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA	17846348
D012965	Sodium Chloride	Sodium Chloride deficiency results in increased expression of REN mRNA	19474190
D012965	Sodium Chloride	[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein	11039
D012965	Sodium Chloride	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]	11832429
D012965	Sodium Chloride	Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]	11832429
D012965	Sodium Chloride	Sodium Chloride deficiency results in increased activity of REN protein	11832429
D012965	Sodium Chloride	Sodium Chloride deficiency results in increased expression of REN mRNA	11832429
D012965	Sodium Chloride	Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]	235222
D017673	Sodium Chloride, Dietary	"[AGTR1A co-treated with Sodium Chloride, Dietary] results in decreased expression of REN mRNA"	21424707
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary affects the expression of REN mRNA"	14504926
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN mRNA]"	26781276
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN protein]"	26781276
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in decreased expression of REN mRNA"	21424707
D017673	Sodium Chloride, Dietary	"[Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein"	7541960
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency results in increased activity of REN protein"	10432392
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in decreased activity of REN protein"	10432392
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in decreased expression of REN mRNA"	18796534\|1921169
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in decreased expression of REN protein"	19211690
D012982	Sodium, Dietary	"CD38 gene mutant form promotes the reaction [Sodium, Dietary deficiency results in increased activity of REN protein]"	23343681
D012982	Sodium, Dietary	"Sodium, Dietary deficiency results in increased activity of REN protein"	23343681
D012982	Sodium, Dietary	"[Sodium, Dietary deficiency results in increased susceptibility to 1-Methyl-3-isobutylxanthine] which results in increased secretion of REN protein"	10432392
D012982	Sodium, Dietary	"[Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein"	10432392
D012982	Sodium, Dietary	"[Sodium, Dietary deficiency results in increased susceptibility to Dinoprostone] which results in increased secretion of REN protein"	10432392
D012982	Sodium, Dietary	"[Sodium, Dietary deficiency results in increased susceptibility to Isoproterenol] which results in increased secretion of REN protein"	10432392
D012982	Sodium, Dietary	"Sodium, Dietary results in decreased activity of REN protein"	23343681
C056684	soyasaponin I	soyasaponin I results in decreased activity of REN protein	19060406\|2046074
C106126	soyasaponin II	soyasaponin II results in decreased activity of REN protein	20460744
C052555	spirapril	spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	9300315
C052555	spirapril	spirapril results in increased expression of REN mRNA	1764812
C052555	spirapril	spirapril results in increased expression of REN protein	1764812\|9300315
D013148	Spironolactone	[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein	12014310
D013148	Spironolactone	REN protein results in decreased susceptibility to Spironolactone	6998872
D013148	Spironolactone	Spironolactone results in increased expression of REN protein	20016520\|9595286
D010042	Ouabain	Ouabain results in decreased secretion of REN protein	6093556
D010042	Ouabain	Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]	6093556
D013467	Sulindac	Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]	4028619
D013467	Sulindac	Sulindac results in decreased activity of REN protein	2203262\|3884224
D016559	Tacrolimus	nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]	7533848
D016559	Tacrolimus	Tacrolimus results in decreased activity of REN protein	7509514
D016559	Tacrolimus	Tacrolimus results in increased expression of REN mRNA	12469222\|2186529
D016559	Tacrolimus	Tacrolimus results in increased expression of REN protein	7532090\|7533848
C084178	telmisartan	telmisartan results in increased expression of REN mRNA	9533614
C084178	telmisartan	telmisartan results in increased expression of REN protein	9533614
D013726	Terbutaline	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D013726	Terbutaline	Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D013726	Terbutaline	Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9203624
D013726	Terbutaline	[IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D013726	Terbutaline	Terbutaline results in increased expression of REN mRNA	9203624
D013726	Terbutaline	Terbutaline results in increased secretion of REN protein	9203624\|9256163
D013726	Terbutaline	TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]	9256163
D043343	Testosterone Propionate	Testosterone Propionate results in increased expression of REN mRNA	1568764
D043343	Testosterone Propionate	Testosterone Propionate results in increased expression of REN protein	1568764
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of REN mRNA	27914987
D013806	Theophylline	Theophylline affects the expression of REN protein	7743391
D013989	Ticrynafen	Ticrynafen results in increased activity of REN protein	6756707
C009495	titanium dioxide	titanium dioxide results in decreased expression of REN mRNA	26277626
C009495	titanium dioxide	titanium dioxide results in decreased expression of REN protein	26277626
C026116	torsemide	torsemide results in increased expression of REN protein	7954537
C052035	trandolapril	[Bumetanide co-treated with trandolapril] results in increased expression of REN protein	16635047
C052035	trandolapril	trandolapril results in increased expression of REN protein	16635047
C052035	trandolapril	trandolapril results in increased expression of REN protein	27428043
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of REN gene	27618143
D014635	Valproic Acid	Valproic Acid results in increased methylation of REN gene	29154799
D000068756	Valsartan	[benazepril co-treated with Valsartan] results in increased activity of REN protein	10836730
D000068756	Valsartan	[benazepril co-treated with Valsartan] results in increased activity of REN protein	11501062
D000068756	Valsartan	Valsartan results in increased activity of REN protein	11501062
D000068756	Valsartan	Valsartan results in increased expression of REN protein	8505092
D014638	Vanadates	Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]	6093556
C006027	xibenolol	xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	6103674
D015016	Yohimbine	Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Propranolol inhibits the reaction [Yohimbine results in increased expression of REN protein]	6323192
D015016	Yohimbine	Yohimbine results in increased expression of REN protein	6323192
C076903	zankiren hydrochloride	zankiren hydrochloride results in decreased activity of REN protein	15662231
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of REN mRNA	27504894

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004190	aspartic-type endopeptidase activity	-	EXP	4289389 4322712 4330891 4360430 12045255
GO:0004190	aspartic-type endopeptidase activity	-	IBA	21873635
GO:0004190	aspartic-type endopeptidase activity	-	IDA	12045255
GO:0005102	signaling receptor binding	-	IPI	12045255
GO:0005159	insulin-like growth factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	20927107
GO:0008233	peptidase activity	-	IDA	12045255

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001822	kidney development	-	IMP	16116425
GO:0001823	mesonephros development	-	IEA	-
GO:0002003	angiotensin maturation	-	IBA	21873635
GO:0002003	angiotensin maturation	-	IDA	12045255
GO:0002003	angiotensin maturation	-	TAS	-
GO:0002018	renin-angiotensin regulation of aldosterone production	-	IEA	-
GO:0006508	proteolysis	-	IBA	21873635
GO:0006508	proteolysis	-	IDA	12045255
GO:0008217	regulation of blood pressure	-	TAS	7584914
GO:0008584	male gonad development	-	IEA	-
GO:0009755	hormone-mediated signaling pathway	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0035690	cellular response to drug	-	IEA	-
GO:0035902	response to immobilization stress	-	IEA	-
GO:0042756	drinking behavior	-	IEA	-
GO:0043408	regulation of MAPK cascade	-	IDA	12045255
GO:0048469	cell maturation	-	IEA	-
GO:0050435	amyloid-beta metabolic process	-	IEA	-
GO:0051591	response to cAMP	-	IEA	-
GO:0070305	response to cGMP	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	12045255 26322847
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0045177	apical part of cell	-	IDA	26322847

KEGG ID	KEGG Term
hsa04614	Renin-angiotensin system

Reactome ID	Reactome Term	Evidence
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-392499	Metabolism of proteins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
10665661	Human renin gene BglI dimorphism associated with hypertension in two independent populations. (1999 Dec)	Frossard PM	Clin Genet
7949276	Social intergration and change in activities of daily living in Japanese elderly. (1994 Oct)	Sugisawa H	Nihon Koshu Eisei Zasshi
27742538	Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives. (2017 Aug)	Pang J	Biochim Biophys Acta
26102248	The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting. (2015 Aug)	Fragoso JM	Exp Mol Pathol
9786608	An MboI two-allele polymorphism may implicate the human renin gene in primary hypertension. (1998 Sep)	Frossard PM	Hypertens Res
18789824	Arsenicosis status and urinary malondialdehyde (MDA) in people exposed to arsenic contaminated-coal in China. (2009 Apr)	Wang JP	Environ Int
8161829	[Social integration and mortality in Japanese elderly]. (1994 Feb)	Sugisawa H	Nihon Koshu Eisei Zasshi
17286790	Applications of population pharmacokinetics in current drug labelling. (2007 Feb)	Duan JZ	J Clin Pharm Ther
26346534	Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial. (2015)	Chan YY	Evid Based Complement Alternat Med