Gene: UPF1

5976
HUPF1|NORF1|RENT1|pNORF1|smg-2
UPF1, RNA helicase and ATPase
protein-coding
19p13.11
Ensembl:ENSG00000005007 MIM:601430 Vega:OTTHUMG00000183025 UniprotKB:Q92900
NC_000019.10
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.288e-1 (AD)  5.819e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01566552chr19:18977814UPF13'UTR4.601e-4Alcohol use disorders26763658
cg14207833chr19:18945153UPF18.110e-8Maternal smoking in pregnancy27040690
cg18824330chr19:18960246UPF17.400e-12Smoking27651444
cg18824330chr19:18960246UPF11.390e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KHSRP0.928
ARHGEF180.922
SMG50.921
ZC3H180.92
GAK0.92
PYGO20.913
TADA2B0.912
SURF40.912
TPD52L20.912
SYVN10.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.691
OR4F29-0.646
KLRB1-0.346
CETP-0.319
KLRF1-0.317
C9orf153-0.297
CPA3-0.291
GZMK-0.288
IL2RB-0.287
OR6C74-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol binds to UPF1 protein"22384159
D020106AcrylamideAcrylamide results in decreased expression of UPF1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UPF1 mRNA19770486
D001151ArsenicArsenic affects the methylation of UPF1 gene25304211
D001280AtrazineAtrazine results in decreased expression of UPF1 mRNA25929836
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of UPF1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to UPF1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UPF1 mRNA19770486|2222880
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of UPF1 mRNA20404318
C044887beta-methylcholinebeta-methylcholine affects the expression of UPF1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of UPF1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UPF1 mRNA25181051
D002166CamptothecinUPF1 mRNA results in decreased susceptibility to Camptothecin25269479
D002330CarmustineCarmustine results in decreased expression of UPF1 mRNA15980968
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of UPF1 gene20938992
D016572CyclosporineCyclosporine results in decreased expression of UPF1 mRNA19770486
D003976DiazinonDiazinon results in increased methylation of UPF1 gene22964155
C000944dicrotophosdicrotophos results in increased expression of UPF1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of UPF1 mRNA25016146
D004221DisulfiramDisulfiram results in decreased expression of UPF1 mRNA20530235
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of UPF1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UPF1 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of UPF1 intron27776689
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of UPF1 gene20938992
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of UPF1 mRNA16849584
C410337K 7174K 7174 results in decreased expression of UPF1 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of UPF1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UPF1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of UPF1 mRNA"20188158
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to UPF1 protein]17220478
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of UPF1 mRNA22401849
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of UPF1 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of UPF1 protein26879310
C006253pirinixic acidpirinixic acid results in decreased expression of UPF1 mRNA18445702
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of UPF1 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA19059307
C017947sodium arsenitesodium arsenite affects the expression of UPF1 mRNA29319823
D012969Sodium FluorideSodium Fluoride results in increased expression of UPF1 mRNA27862939
D013629TamoxifenTamoxifen affects the expression of UPF1 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UPF1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UPF1 mRNA17942748
D013849ThimerosalThimerosal results in decreased expression of UPF1 mRNA27188386
D013893ThiramThiram results in decreased expression of UPF1 mRNA20530235
C483909torcetrapibtorcetrapib results in increased expression of UPF1 mRNA23228038
C057693troglitazonetroglitazone results in decreased expression of UPF1 mRNA28973697
D014520UrethaneUrethane results in increased expression of UPF1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of UPF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of UPF1 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of UPF1 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of UPF1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA16488880  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-NAS10999600  
GO:0004004ATP-dependent RNA helicase activity-IBA21873635  
GO:0004004ATP-dependent RNA helicase activity-IDA12554878  21419344  
GO:0004386helicase activity-NAS9064659  
GO:0005515protein binding-IPI9620853  11163187  11544179  12417715  12881429  14636577  
15680326  16086026  16364915  16488880  16601204  17468741  
17469741  17932509  18256688  18362360  18447585  19150429  
19417104  19478851  19503078  19556969  19864460  20930030  
21829167  23348841  23722113  23788676  24267889  24965446  
25225333  26000482  26255671  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0042162telomeric DNA binding-IDA17916692  21829167  
GO ID GO Term Qualifier Evidence PubMed
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-IBA21873635  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-IDA17468741  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-IMP18369367  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-NAS10999600  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS8855285  
GO:0000294nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay-IMP26255671  
GO:0000956nuclear-transcribed mRNA catabolic process-IMP23828042  
GO:0006260DNA replication-IMP16488880  
GO:0006281DNA repair-IDA16488880  
GO:0006406mRNA export from nucleus-TAS16488880  
GO:0006449regulation of translational termination-IMP9620853  
GO:0006449regulation of translational termination-NAS10999600  
GO:0009048dosage compensation by inactivation of X chromosome-IEA-  
GO:0032201telomere maintenance via semi-conservative replication-IDA21829167  
GO:0032204regulation of telomere maintenance-IMP17916692  
GO:0044770cell cycle phase transition-IMP16488880  
GO:0061014positive regulation of mRNA catabolic process-IMP25225333  26255671  
GO:00611583'-UTR-mediated mRNA destabilization-IMP26255671  
GO:0071044histone mRNA catabolic process-IMP16086026  
GO:0071222cellular response to lipopolysaccharide-IDA26255671  
GO:0071347cellular response to interleukin-1-IDA26255671  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IDA21829167  
GO:0000785chromatin-IDA16488880  
GO:0000932P-body-IEA-  
GO:0005634nucleus-IDA18362360  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-NAS9064659  
GO:0005829cytosol-TAS-  
GO:0035145exon-exon junction complex-IDA16601204  
GO:0044530supraspliceosomal complex-IDA18362360  
KEGG ID KEGG Term
hsa03013RNA transport
hsa03015mRNA surveillance pathway
Reactome ID Reactome Term Evidence
R-HSA-8953854Metabolism of RNATAS
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24810251Alterations of bronchial epithelial metabolome by cigarette smoke are reversible by an antioxidant, O-methyl-L-tyrosinyl-gamma-L-glutamyl-L-cysteinylglycine. (2014 Oct)Aug AAm J Respir Cell Mol Biol
26536230E-Cigarette Affects the Metabolome of Primary Normal Human Bronchial Epithelial Cells. (2015)Aug APLoS One