Gene: DPF2

5977
REQ|UBID4|ubi-d4
double PHD fingers 2
protein-coding
11q13.1
Ensembl:ENSG00000133884 MIM:601671 Vega:OTTHUMG00000165985 UniprotKB:Q92785
NC_000011.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.066e-1 (AD)  2.023e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLDIP30.927
TXLNA0.896
CRTC20.893
SYVN10.893
RAF10.892
TPD52L20.891
AUP10.89
ACIN10.889
NELFCD0.886
IST10.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.74
OR4F29-0.713
IFNG-0.191
SPRR2B-0.186
CETP-0.185
FMO1-0.182
OR4F16-0.18
HMHB1-0.179
FER1L6-0.173
OR6C74-0.166

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DPF2 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of DPF2 mRNA22230336
D001280AtrazineAtrazine results in increased expression of DPF2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DPF2 mRNA19770486|2050435
C006780bisphenol Abisphenol A results in increased expression of DPF2 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of DPF2 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of DPF2 mRNA19320972
D003042CocaineCocaine results in increased expression of DPF2 mRNA18000554
D003976DiazinonDiazinon affects the expression of DPF2 mRNA22546817
C000944dicrotophosdicrotophos results in increased expression of DPF2 mRNA28302478
D004126DimethylformamideDimethylformamide results in increased expression of DPF2 mRNA22169935
D004221DisulfiramDisulfiram results in decreased expression of DPF2 mRNA20530235
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DPF2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DPF2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DPF2 mRNA23649840
C492448ICG 001ICG 001 results in increased expression of DPF2 mRNA26191083
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of DPF2 mRNA16835149
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DPF2 mRNA23649840
C025256nonylphenolnonylphenol results in increased expression of DPF2 mRNA22982499
C010327salinomycinsalinomycin results in decreased expression of DPF2 mRNA19682730
D014284TriiodothyronineTriiodothyronine results in decreased expression of DPF2 mRNA17399805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DPF2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of DPF2 protein23298284
D013893ThiramThiram results in decreased expression of DPF2 mRNA20530235
D014520UrethaneUrethane results in increased expression of DPF2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DPF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DPF2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DPF2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of DPF2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-HDA16217013  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0004402histone acetyltransferase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0042393histone binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006915apoptotic process-TAS8812431  
GO:0007399nervous system development-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0097190apoptotic signaling pathway-TAS7961935  
GO ID GO Term Qualifier Evidence PubMed
GO:0000123histone acetyltransferase complex-IBA21873635  
GO:0000790nuclear chromatin-HDA16217013  
GO:0000790nuclear chromatin-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0071565nBAF complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res