Gene info: ID 5979

Gene: RET

GENE ID: 5979

Description: ret proto-oncogene

Gene type: protein-coding

Location: 10q11.21

dbXrefs: Ensembl:ENSG00000165731 MIM:164761 Vega:OTTHUMG00000018024 UniprotKB:P07949

RefSeq: NG_007489.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 41

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.346e-1 (AD) 1.610e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg09848445	chr10:43601862	RET		6.500e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EXTL2	0.912
SCN1A	0.91
SPTSSB	0.904
CADPS	0.903
LSM11	0.9
RIT2	0.891
MCF2	0.891
SYT4	0.891
GABRG2	0.889
EIF5A2	0.889

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YES1	-0.541
HEY2	-0.53
REST	-0.525
RAI14	-0.508
WWTR1	-0.505
RAB13	-0.501
MYOM1	-0.497
ASB4	-0.493
CNN2	-0.486
MTRNR2L8	-0.484

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00619	Imatinib	Small Molecule	152459-95-5	Approved	Target
DB05014	XL999	Small Molecule	921206-68-0	Investigational	Target
DB00398	Sorafenib	Small Molecule	284461-73-0	Approved\|Investigational	Target
DB01809	1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine	Small Molecule		Experimental	Target
DB05294	Vandetanib	Small Molecule	443913-73-3	Approved	Target
DB08875	Cabozantinib	Small Molecule	849217-68-1	Approved\|Investigational	Target
DB08896	Regorafenib	Small Molecule	755037-03-7	Approved	Target
DB08901	Ponatinib	Small Molecule	943319-70-8	Approved\|Investigational	Target
DB12742	Amuvatinib	Small Molecule	850879-09-3	Investigational	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RET mRNA"	25510870
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RET mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RET mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RET mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RET mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RET mRNA"	25510870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNA"	27188386
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine results in decreased activity of RET protein"	16940797
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNA"	27188386
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of RET mRNA]	21233418
D000447	Aldehydes	Aldehydes results in increased expression of RET mRNA	25014914
D000452	Aldrin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RET mRNA	16483693
D000841	Anisomycin	Anisomycin results in decreased expression of RET protein	17555550
D001151	Arsenic	[Arsenic co-treated with RET protein alternative form] results in increased secretion of MMP2 protein alternative form	21195159
D001151	Arsenic	[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form	21195159
D001151	Arsenic	Arsenic promotes the reaction [RET protein alternative form binds to RET protein alternative form]	21195159
D001151	Arsenic	Arsenic results in increased activity of RET protein	21195159
D001151	Arsenic	Arsenic results in increased activity of RET protein alternative form	21195159
D001151	Arsenic	Cysteine inhibits the reaction [[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form]	21195159
D001374	Azacitidine	Azacitidine results in decreased expression of RET mRNA	20823114
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RET mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RET mRNA	21839799
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RET mRNA	20823114
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA	24758408
D004958	Estradiol	Estradiol results in increased expression of RET mRNA	24758408\|2686566
D004958	Estradiol	Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA]	24758408
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of RET mRNA]	24758408
C006780	bisphenol A	bisphenol A results in increased expression of RET mRNA	28711546
C006780	bisphenol A	bisphenol A results in decreased methylation of RET promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of RET mRNA	27312807
C006780	bisphenol A	bisphenol A results in increased methylation of RET promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of RET mRNA	12075121\|2518105
C018475	butyraldehyde	butyraldehyde results in increased expression of RET mRNA	26079696
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNA	12634122
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RET mRNA	20360939
D002166	Camptothecin	Camptothecin results in decreased expression of RET protein	17555550
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of RET mRNA	12734012
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of RET mRNA	26272509
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of RET mRNA	20350560
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNA	12634122
D002996	Clomiphene	Clomiphene results in decreased expression of RET mRNA	26865669
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RET mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RET mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of RET mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of RET mRNA	27523638
D003513	Cycloheximide	Cycloheximide results in decreased expression of RET protein	17555550
D003545	Cysteine	Cysteine inhibits the reaction [[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form]	21195159
D003634	DDT	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of RET mRNA	23914054
C017180	decamethrin	decamethrin results in increased expression of RET mRNA	19017407
D003976	Diazinon	Diazinon affects the expression of RET mRNA	22546817
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RET mRNA	20823114
D002945	Cisplatin	Cisplatin results in decreased expression of RET protein	17555550
D003632	Dichlorodiphenyldichloroethane	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
D003633	Dichlorodiphenyl Dichloroethylene	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
D004008	Diclofenac	Diclofenac results in increased expression of RET mRNA	26934552
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of RET mRNA	26924002
D004026	Dieldrin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
D004026	Dieldrin	Dieldrin affects the expression of RET mRNA	22546817
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RET mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of RET mRNA	26865669
D002117	Calcitriol	Calcitriol results in increased expression of RET mRNA	16002434
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of RET mRNA	26924002
D004732	Endrin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
C118739	entinostat	entinostat results in increased expression of RET mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNA"	27188386
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of RET mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of RET mRNA	21233418
D004970	Estrone	Estrone results in increased expression of RET mRNA	26865669
D000431	Ethanol	Ethanol affects the expression of RET mRNA	22198099
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of RET mRNA	12075121
D008656	Mestranol	Mestranol results in increased expression of RET mRNA	26865669
D004397	Fonofos	Fonofos results in increased methylation of RET promoter	22847954
C070081	fulvestrant	fulvestrant results in decreased expression of RET mRNA	26865669
D019833	Genistein	Genistein results in increased expression of RET mRNA	26865669
D019833	Genistein	Genistein results in increased expression of RET mRNA	12075121
D005947	Glucose	Glucose results in increased expression of RET mRNA	21818840
D006025	Glycosaminoglycans	Glycosaminoglycans affects the reaction [GDNF protein promotes the reaction [GFRA1 protein results in increased activity of RET protein]]	20807638
D017313	Fenretinide	Fenretinide results in decreased expression of RET mRNA	28973697
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased phosphorylation of RET protein	15709206
C081309	irbesartan	irbesartan results in increased expression of RET protein	16164579
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNA	12634122
C008261	lead acetate	lead acetate results in increased expression of RET mRNA	22641619
C533894	LG 100815	LG 100815 results in decreased expression of RET mRNA	16951191
D001556	Lindane	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
D008094	Lithium	[Lithium co-treated with Pilocarpine] results in increased expression of RET protein	12914250
C025340	manganese chloride	manganese chloride results in decreased expression of RET protein	17555550
D008468	Meclizine	Meclizine affects the expression of RET protein	12388792
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RET mRNA	20823114
D008535	Megestrol	Megestrol affects the expression of RET protein	12388792
C042720	mercuric bromide	mercuric bromide results in decreased expression of RET mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
D008704	Methazolamide	Methazolamide affects the expression of RET protein	12388792
D008713	Methimazole	Methimazole results in increased expression of RET mRNA	22504374
D008713	Methimazole	Methimazole results in increased expression of RET protein	22504374
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of RET mRNA	28001369
D008774	Methylphenidate	Methylphenidate results in decreased expression of RET mRNA	22470460
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of RET mRNA	16026605
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RET protein"	17555550
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of RET mRNA	26924002
C568507	N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide	"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of RET protein"	21888390
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased phosphorylation of RET protein	17431108
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased activity of RET protein	16940797\|1743110
D009532	Nickel	Nickel results in decreased expression of RET mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of RET mRNA	22546817
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in decreased expression of RET mRNA"	16951191
D016627	Oxidopamine	RET protein mutant form results in decreased susceptibility to Oxidopamine	19767128
C507134	ON 01910	ON 01910 results in increased phosphorylation of RET protein	25472472
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of RET mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of RET mRNA]"	21673326
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of RET mRNA	25729387
D010278	Parathion	Parathion results in increased methylation of RET promoter	22847954
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RET mRNA"	25510870
C046012	pentanal	pentanal results in increased expression of RET mRNA	26079696
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RET mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of RET mRNA	26272509
D010862	Pilocarpine	[Lithium co-treated with Pilocarpine] results in increased expression of RET protein	12914250
D010936	Plant Extracts	Plant Extracts results in decreased expression of RET mRNA	23557933
C545373	ponatinib	ponatinib analog results in decreased activity of RET protein	21561767
C545373	ponatinib	ponatinib results in decreased activity of RET protein	19878872
C545373	ponatinib	ponatinib results in decreased activity of RET protein mutant form	19878872
C045362	prochloraz	prochloraz results in increased expression of RET mRNA	21470553
D011374	Progesterone	Progesterone results in decreased expression of RET mRNA	19690047
C005556	propionaldehyde	propionaldehyde results in increased expression of RET mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of RET mRNA	22504374\|2478091
D011441	Propylthiouracil	Propylthiouracil results in increased expression of RET protein	22504374
C043680	ptaquiloside	ptaquiloside results in decreased expression of RET mRNA	23274088
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RET mRNA	19059307
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RET mRNA	19059307
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of RET mRNA	26865669
D012110	Reserpine	Reserpine results in increased expression of RET mRNA	15837122
D012110	Reserpine	Reserpine results in increased expression of RET protein	15837122
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of RET mRNA	19167446
D012402	Rotenone	Rotenone results in decreased expression of RET mRNA	17555550
D012402	Rotenone	Rotenone results in decreased expression of RET protein	17555550
D019821	Simvastatin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA	28263720
C017947	sodium arsenite	sodium arsenite affects the methylation of RET gene	28589171
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNA	12634122
D012999	Soman	Soman results in increased expression of RET mRNA	19281266
C471405	sorafenib	sorafenib results in decreased activity of RET protein	17664273
C471405	sorafenib	sorafenib results in decreased activity of RET protein mutant form	17664273
C471405	sorafenib	sorafenib results in increased degradation of RET protein	17664273
D019311	Staurosporine	Staurosporine results in decreased expression of RET protein	17555550
D013467	Sulindac	Sulindac affects the expression of RET protein	12388792
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in increased expression of RET mRNA	19059307
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RET mRNA	19059307
D013629	Tamoxifen	Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA]	24758408
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of RET mRNA]	24758408
C012568	terbufos	terbufos results in increased methylation of RET promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RET mRNA	22903824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RET mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RET mRNA	17337447
D019284	Thapsigargin	Thapsigargin results in decreased expression of RET mRNA	22378314
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of RET mRNA	25729387
D014212	Tretinoin	RET protein results in increased susceptibility to Tretinoin	16849523
D014212	Tretinoin	Tretinoin results in increased expression of and results in increased phosphorylation of and results in increased activity of RET protein	16849523
D014212	Tretinoin	Tretinoin results in increased expression of RET mRNA	16012519\|1743110
D014212	Tretinoin	Tretinoin results in increased expression of RET protein	17435603
D014212	Tretinoin	Tretinoin results in increased phosphorylation of RET protein	17431108
D014212	Tretinoin	[Tretinoin results in increased secretion of GDNF protein] which results in increased activity of RET protein	16849523
D014212	Tretinoin	Tretinoin results in increased expression of RET mRNA	20488242
C012589	trichostatin A	trichostatin A results in increased expression of RET mRNA	24935251
D014415	Tunicamycin	Tunicamycin results in decreased expression of RET mRNA	22378314
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of RET mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of RET mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of RET gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of RET mRNA	17963808
D014700	Verapamil	Verapamil affects the expression of RET protein	12388792
C111237	vorinostat	vorinostat results in decreased expression of RET mRNA	27188386
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of RET mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	TAS	7824936
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IDA	28846099
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	TAS	-
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005509	calcium ion binding	-	IDA	11445581
GO:0005515	protein binding	-	IPI	8628282 10545102 11536047 12727845 15677445 16569669 17471236 20877310 25241761 25416956 28846097 28846099 28953886
GO:0005524	ATP binding	-	IEA	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0038023	signaling receptor activity	-	TAS	7824936

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0000187	activation of MAPK activity	-	IMP	28953886
GO:0001657	ureteric bud development	-	IEA	-
GO:0001755	neural crest cell migration	-	IEA	-
GO:0001838	embryonic epithelial tube formation	-	IEA	-
GO:0006468	protein phosphorylation	-	TAS	7824936
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	IEA	-
GO:0007158	neuron cell-cell adhesion	-	IMP	21357690
GO:0007165	signal transduction	-	TAS	7824936
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007411	axon guidance	-	TAS	-
GO:0007497	posterior midgut development	-	TAS	8114939
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010976	positive regulation of neuron projection development	-	IMP	17910947
GO:0014042	positive regulation of neuron maturation	-	IEA	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030155	regulation of cell adhesion	-	IDA	21357690
GO:0030335	positive regulation of cell migration	-	IDA	20702524
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	-	IEA	-
GO:0033619	membrane protein proteolysis	-	IDA	21357690
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	IDA	20702524
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0035799	ureter maturation	-	IEA	-
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	-	IDA	28953886
GO:0042493	response to drug	-	IEA	-
GO:0042551	neuron maturation	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IDA	28846099
GO:0045793	positive regulation of cell size	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	17047028
GO:0048265	response to pain	-	ISS	-
GO:0048484	enteric nervous system development	-	IEA	-
GO:0050770	regulation of axonogenesis	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IMP	28846097
GO:0060041	retina development in camera-type eye	-	IEA	-
GO:0060384	innervation	-	IEA	-
GO:0061146	Peyer's patch morphogenesis	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0071300	cellular response to retinoic acid	-	IMP	17910947
GO:0072300	positive regulation of metanephric glomerulus development	-	ISS	17047028
GO:0097021	lymphocyte migration into lymphoid organs	-	ISS	-
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	TAS	21357690

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005769	early endosome	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	28953886
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	19823924
GO:0010008	endosome membrane	-	IDA	19823924
GO:0030424	axon	-	IBA	21873635
GO:0030424	axon	-	IEA	-
GO:0030425	dendrite	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0043235	receptor complex	-	IBA	21873635
GO:0043235	receptor complex	-	IDA	23382219
GO:0045121	membrane raft	-	IEA	-
GO:0098797	plasma membrane protein complex	-	IDA	10545102

KEGG ID	KEGG Term
hsa04144	Endocytosis
hsa05200	Pathways in cancer
hsa05216	Thyroid cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-8853659	RET signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27262212	Identifying the Appropriate FISH Criteria for Defining MET Copy Number-Driven Lung Adenocarcinoma through Oncogene Overlap Analysis. (2016 Aug)	Noonan SA	J Thorac Oncol
27027665	Gene aberrations for precision medicine against lung adenocarcinoma. (2016 Jun)	Saito M	Cancer Sci
28280984	Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy. (2018 Jan)	Saito M	Surg Today
25855381	Development of lung adenocarcinomas with exclusive dependence on oncogene fusions. (2015 Jun 1)	Saito M	Cancer Res
26705279	[Detection of ALK, ROS1 and RET fusion genes in non-small cell lung cancer patients and its clinicopathologic correlation]. (2015 Sep)	Zhong S	Zhonghua Bing Li Xue Za Zhi
24037524	ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation. (2014 Jul 17)	Kosari F	Oncogene
23877438	CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (2013 Oct)	Matsuura S	Oncol Rep
26955281	The prevalence and prognostic significance of KRAS mutation subtypes in lung adenocarcinomas from Chinese populations. (2016)	Zheng D	Onco Targets Ther
24504365	RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. (2014 Mar 18)	Tsuta K	Br J Cancer
21432543	Effect of gene polymorphisms and ethanol consumption on micronucleus frequency in human reticulocytes: a preliminary study. (2010 May)	Wu C	Environ Health Prev Med
27635639	Clinicopathological characteristics and survival of ALK, ROS1 and RET rearrangements in non-adenocarcinoma non-small cell lung cancer patients. (2017 Nov 2)	Song Z	Cancer Biol Ther
15659598	Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. (2005 Jan 19)	He DY	J Neurosci
25152623	Oncogenic mutations are associated with histological subtypes but do not have an independent prognostic value in lung adenocarcinoma. (2014)	Hu H	Onco Targets Ther
23378251	KIF5B-RET fusions in Chinese patients with non-small cell lung cancer. (2013 Apr 15)	Cai W	Cancer
28676214	DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel. (2017 Aug)	Takamochi K	Lung Cancer
25773866	Clinical and prognostic implications of RET rearrangements in metastatic lung adenocarcinoma patients with malignant pleural effusion. (2015 May)	Tsai TH	Lung Cancer
29128428	Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer. (2018 Jan)	Ferrara R	J Thorac Oncol
26437441	Molecular Process Producing Oncogene Fusion in Lung Cancer Cells by Illegitimate Repair of DNA Double-Strand Breaks. (2015 Sep 30)	Seki Y	Biomolecules
23802154	Correlation between total blood lead values and peripheral blood counts in workers occupationally exposed to urban stressors. (2013)	Caciari T	J Environ Sci Health A Tox Hazard Subst Environ Eng
26762747	Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients. (2016 Jan)	Michels S	J Thorac Oncol
21707421	Micronucleus frequencies in lymphocytes and reticulocytes in a pesticide-exposed population in Portugal. (2011)	Costa C	J Toxicol Environ Health A
25870798	Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. (2015 Apr)	Kohno T	Transl Lung Cancer Res
28881815	Clinicopathological characteristics of ROS1- and RET-rearranged NSCLC in caucasian patients: Data from a cohort of 713 non-squamous NSCLC lacking KRAS/EGFR/HER2/BRAF/PIK3CA/ALK alterations. (2017 Aug 8)	Dugay F	Oncotarget
29799009	Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients. (2018 May 24)	Wang C	Nat Commun
23342255	RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer. (2012 Aug)	Sasaki H	Cancer Med
27033383	[Correlation of clinicopathologic features and driver gene mutation in non-small cell lung cancer]. (2016 Apr 8)	Chen LF	Zhonghua Bing Li Xue Za Zhi
22975805	The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)	Seo JS	Genome Res
27298405	Management of Brain Metastases in ALK-Positive Non-Small-Cell Lung Cancer. (2016 Aug 20)	Rusthoven CG	J Clin Oncol
25567908	Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)	Drilon A	Clin Cancer Res
29137260	Pathologic subtype-defined prognosis is dependent on both tumor stage and status of oncogenic driver mutations in lung adenocarcinoma. (2017 Oct 10)	Dong Y	Oncotarget
28914263	Coexistent genetic alterations involving ALK, RET, ROS1 or MET in 15 cases of lung adenocarcinoma. (2018 Feb)	Tang Z	Mod Pathol
25975578	The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. (2015)	Lin C	Cancer Biol Ther
23150706	RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. (2012 Dec 10)	Wang R	J Clin Oncol
24850843	FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)	Wang R	Clin Cancer Res
27001591	Optimizing Treatment Risk and Benefit for Elderly Patients With Advanced Non-Small-Cell Lung Cancer: The Right Treatment for the Right Patient. (2016 May 1)	Presley CJ	J Clin Oncol
24163741	Molecular biology of lung cancer. (2013 Oct)	Cooper WA	J Thorac Dis
29780256	The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients. (2018)	Cao L	Onco Targets Ther
21790673	Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. (2012 Jan)	Sakharkar AJ	Alcohol Clin Exp Res
27008586	Clinicopathologic Characteristics of Patients with HER2 Insertions in Non-small Cell Lung Cancer. (2017 Jan)	Bu S	Ann Surg Oncol
29217530	The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2). (2018 Mar 1)	Aisner DL	Clin Cancer Res
25180059	Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. (2014 Jun)	Zhao C	Transl Oncol