Gene info: ID 5981

Gene: RFC1

GENE ID: 5981

Description: replication factor C subunit 1

Gene type: protein-coding

Location: 4p14

dbXrefs: Ensembl:ENSG00000035928 MIM:102579 Vega:OTTHUMG00000099363 UniprotKB:P35251

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.833e-1 (AD) 7.055e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NBR1	0.916
DYNC1I2	0.903
RNF20	0.895
ERMP1	0.892
ITCH	0.888
CPSF2	0.887
SGCB	0.885
SCARB2	0.883
FAM208A	0.883
SMARCA5	0.881

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.612
OR4F5	-0.61
MTRNR2L6	-0.243
C10orf113	-0.242
MTRNR2L10	-0.224
RNF223	-0.217
MTRNR2L3	-0.201
MTRNR2L9	-0.199
C8orf74	-0.198
SDIM1	-0.195

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of RFC1 mRNA"	23829299
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of RFC1 mRNA"	23829299
D000082	Acetaminophen	Acetaminophen results in decreased expression of RFC1 mRNA	21420995\|2223033
D000082	Acetaminophen	Acetaminophen affects the expression of RFC1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of RFC1 gene	28458013
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RFC1 mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in increased expression of RFC1 mRNA	21757418
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of RFC1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of RFC1 gene	25304211
D001280	Atrazine	Atrazine results in increased expression of RFC1 mRNA	25929836
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RFC1 mRNA"	19150397\|2038263
C006780	bisphenol A	bisphenol A affects the expression of RFC1 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of RFC1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of RFC1 protein	24552547
C006780	bisphenol A	bisphenol A results in decreased expression of RFC1 mRNA	26794494
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased phosphorylation of RFC1 protein	22174045
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RFC1 mRNA	20360939
D002220	Carbamazepine	Carbamazepine affects the expression of RFC1 mRNA	25979313
D003078	Colchicine	Colchicine results in decreased expression of RFC1 mRNA	24211769
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of RFC1 mRNA	21878529
D016572	Cyclosporine	Cyclosporine results in increased expression of RFC1 mRNA	27989131
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RFC1 mRNA]	27941970
D002945	Cisplatin	Cisplatin results in decreased expression of RFC1 mRNA	24211769
D002945	Cisplatin	Cisplatin results in increased expression of RFC1 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of RFC1 mRNA	21151649
C000944	dicrotophos	dicrotophos results in decreased expression of RFC1 mRNA	28302478
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of RFC1 mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RFC1 mRNA]	17854601
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RFC1 mRNA	20360939
D004317	Doxorubicin	RFC1 protein results in decreased susceptibility to Doxorubicin	24675091
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RFC1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFC1 mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of RFC1 mRNA	24211769
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of RFC1 mRNA	23649840
D005047	Etoposide	Etoposide results in decreased expression of RFC1 mRNA	24211769
D018120	Finasteride	Finasteride results in increased expression of RFC1 mRNA	24136188
D005492	Folic Acid	RFC1 protein mutant form promotes the reaction [FOLR1 protein mutant form results in decreased abundance of Folic Acid]	18926688
D005839	Gentamicins	Gentamicins results in increased expression of RFC1 mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of RFC1 mRNA	24136188
C492448	ICG 001	ICG 001 results in increased expression of RFC1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RFC1 mRNA	25613284
C045463	leflunomide	leflunomide results in increased expression of RFC1 mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of RFC1 mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of RFC1 mRNA	10975854
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of RFC1 mRNA	24211769
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RFC1 mRNA	23649840
D016685	Mitomycin	Mitomycin results in decreased expression of RFC1 mRNA	24211769
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of RFC1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RFC1 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RFC1 mRNA	19162173
D010634	Phenobarbital	Phenobarbital results in decreased expression of RFC1 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in decreased expression of RFC1 mRNA	18445702
D010936	Plant Extracts	Plant Extracts results in decreased expression of RFC1 mRNA	24677778
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of RFC1 mRNA	22714537
C017947	sodium arsenite	sodium arsenite results in decreased expression of RFC1 mRNA	12760830
D012999	Soman	Soman results in decreased expression of RFC1 mRNA	19281266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RFC1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFC1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RFC1 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RFC1 mRNA	25613284
D013849	Thimerosal	Thimerosal results in increased expression of RFC1 mRNA	24675092
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of RFC1 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of RFC1 mRNA	28973697
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of RFC1 gene	25560391
D000225	Adenine	Adenine results in decreased expression of RFC1 mRNA	24211769
C070417	Win 55212-2	Win 55212-2 results in increased expression of RFC1 mRNA	12237329

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IBA	21873635
GO:0003689	DNA clamp loader activity	-	IEA	-
GO:0003690	double-stranded DNA binding	-	IEA	-
GO:0005515	protein binding	-	IPI	9488738 15655353 16438930
GO:0005524	ATP binding	-	IEA	-
GO:0008047	enzyme activator activity	-	TAS	8954124
GO:0019904	protein domain specific binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006261	DNA-dependent DNA replication	-	TAS	8248204
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007004	telomere maintenance via telomerase	-	TAS	8954124
GO:0019985	translesion synthesis	-	TAS	-
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	-
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0042276	error-prone translesion synthesis	-	TAS	-
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0043085	positive regulation of catalytic activity	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	-
GO:0070987	error-free translesion synthesis	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005663	DNA replication factor C complex	-	IDA	9488738
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa03030	DNA replication
hsa03420	Nucleotide excision repair
hsa03430	Mismatch repair

Reactome ID	Reactome Term	Evidence
R-HSA-110312	Translesion synthesis by REV1	TAS
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-110320	Translesion Synthesis by POLH	TAS
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	TAS
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-174411	Polymerase switching on the C-strand of the telomere	TAS
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	TAS
R-HSA-5655862	Translesion synthesis by POLK	TAS
R-HSA-5656121	Translesion synthesis by POLI	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-69091	Polymerase switching	TAS
R-HSA-69109	Leading Strand Synthesis	TAS
R-HSA-69186	Lagging Strand Synthesis	TAS
R-HSA-69190	DNA strand elongation	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-73884	Base Excision Repair	TAS
R-HSA-73886	Chromosome Maintenance	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73933	Resolution of Abasic Sites (AP sites)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21597034	The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. (2011 Jun)	Ye X	Psychosom Med
19172696	The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. (2008)	Eklof V	Scand J Clin Lab Invest
25702197	Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). (2015 Mar)	Semmler A	Alcohol
25219684	Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. (2015 Apr)	Bezerra JF	Oral Dis
22479380	Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)	McKay JA	PLoS One
20544798	Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. (2010 Aug)	Summers CM	Birth Defects Res A Clin Mol Teratol