Gene: RFC5

5985
RFC36
replication factor C subunit 5
protein-coding
12q24.23
Ensembl:ENSG00000111445 MIM:600407 Vega:OTTHUMG00000156438 UniprotKB:P40937
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.674e-1 (AD)  4.059e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5745879chr12:118029840 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
METTL60.934
DZIP30.93
PPFIA20.93
VPS33A0.929
KLHL420.928
ATG2B0.926
MTMR40.925
C2CD50.925
RASA10.924
CUL20.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.504
OR4F29-0.465
CSAG1-0.415
MTRNR2L10-0.381
MTRNR2L6-0.371
MTRNR2L9-0.362
KLRB1-0.36
FZD10-0.358
TFPI2-0.358
MAGEA12-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RFC5 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RFC5 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of RFC5 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RFC5 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of RFC5 mRNA28959563
C103505AM 251AM 251 results in decreased expression of RFC5 mRNA16500647
C015001arsenitearsenite results in decreased expression of RFC5 mRNA18929588
D001379AzathioprineAzathioprine results in decreased expression of RFC5 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RFC5 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RFC5 mRNA21714911
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of RFC5 mRNA]15034205
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of RFC5 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RFC5 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RFC5 mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RFC5 mRNA"20382639
C006780bisphenol Abisphenol A affects the expression of RFC5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RFC5 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of RFC5 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RFC5 mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of RFC5 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RFC5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of RFC5 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RFC5 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of RFC5 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of RFC5 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of RFC5 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of RFC5 mRNA20579391
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RFC5 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RFC5 mRNA17361019|2126653
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of RFC5 mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of RFC5 protein20540955
D002945CisplatinCisplatin results in increased expression of RFC5 mRNA27594783
D002945CisplatinCisplatin results in increased phosphorylation of RFC5 protein22006019
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RFC5 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RFC5 mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RFC5 mRNA15766595
D004317DoxorubicinRFC5 protein affects the susceptibility to Doxorubicin16217747
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of RFC5 mRNA25198161
D005485FlutamideFlutamide results in increased expression of RFC5 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of RFC5 mRNA19167457
D017313FenretinideFenretinide results in increased expression of RFC5 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of RFC5 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RFC5 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of RFC5 mRNA21335049
C544151jinfukangjinfukang results in increased expression of RFC5 mRNA27392435
C410337K 7174K 7174 results in decreased expression of RFC5 mRNA24086573
D008345ManganeseManganese results in decreased expression of RFC5 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of RFC5 mRNA17175027
D008748MethylcholanthreneMethylcholanthrene results in increased expression of RFC5 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RFC5 mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of RFC5 mRNA11830524
C063855microcystin RRmicrocystin RR results in increased expression of RFC5 protein19111056
D009151Mustard GasMustard Gas results in decreased expression of RFC5 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RFC5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RFC5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RFC5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RFC5 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RFC5 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of RFC5 mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RFC5 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of RFC5 mRNA26516004
D017239PaclitaxelPaclitaxel results in decreased expression of RFC5 protein15907983
C500026palbociclibpalbociclib results in decreased expression of RFC5 mRNA22869556
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of RFC5 mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of RFC5 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RFC5 protein26879310
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of RFC5 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of RFC5 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of RFC5 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of RFC5 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of RFC5 mRNA21278054
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of RFC5 mRNA19167446
D012402RotenoneRotenone results in increased expression of RFC5 mRNA18191903
D019821SimvastatinSimvastatin results in decreased expression of RFC5 mRNA17428261
C017947sodium arsenitesodium arsenite results in increased expression of RFC5 mRNA12016162
D012999SomanSoman results in decreased expression of RFC5 mRNA19281266
D053260SootSoot results in increased expression of RFC5 mRNA26551751
C061133tamibarotenetamibarotene affects the expression of RFC5 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RFC5 mRNA21802500
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of RFC5 mRNA]15034205
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of RFC5 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RFC5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RFC5 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RFC5 mRNA15034205
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of RFC5 mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RFC5 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of RFC5 protein24648495
C009495titanium dioxidetitanium dioxide results in increased expression of RFC5 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RFC5 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of RFC5 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of RFC5 mRNA15498508
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RFC5 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RFC5 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of RFC5 mRNA19140230
D014747VinblastineRFC5 protein affects the susceptibility to Vinblastine16217747
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of RFC5 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003689DNA clamp loader activityCONTRIBUTES_TOIBA21873635  
GO:0003689DNA clamp loader activitycontributes_toIDA12930902  
GO:0005515protein binding-IPI9488738  16189514  25416956  
GO:0005524ATP binding-IEA-  
GO:0019899enzyme binding-NAS8999859  
GO:0043142single-stranded DNA-dependent ATPase activitycontributes_toIDA12930902  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-NAS8999859  
GO:0006260DNA replication-TAS-  
GO:0006261DNA-dependent DNA replication-IBA21873635  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-NAS8999859  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0019985translesion synthesis-TAS-  
GO:0032201telomere maintenance via semi-conservative replication-TAS-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0042276error-prone translesion synthesis-TAS-  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO:0070987error-free translesion synthesis-TAS-  
GO:1900264positive regulation of DNA-directed DNA polymerase activity-IDA12930902  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005663DNA replication factor C complex-IBA21873635  
GO:0005663DNA replication factor C complex-IDA9488738  
GO:0031390Ctf18 RFC-like complex-IDA12930902  
KEGG ID KEGG Term
hsa03030DNA replication
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
Reactome ID Reactome Term Evidence
R-HSA-110312Translesion synthesis by REV1TAS
R-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateTAS
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-110320Translesion Synthesis by POLHTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-174411Polymerase switching on the C-strand of the telomereTAS
R-HSA-174417Telomere C-strand (Lagging Strand) SynthesisTAS
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-180786Extension of TelomeresTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-5655862Translesion synthesis by POLKTAS
R-HSA-5656121Translesion synthesis by POLITAS
R-HSA-5656169Termination of translesion DNA synthesisTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69091Polymerase switchingTAS
R-HSA-69109Leading Strand SynthesisTAS
R-HSA-69186Lagging Strand SynthesisTAS
R-HSA-69190DNA strand elongationTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal