Gene: TRIM27

5987
RFP|RNF76
tripartite motif containing 27
protein-coding
6p22.1
Ensembl:ENSG00000204713 MIM:602165 Vega:OTTHUMG00000031215 UniprotKB:P14373
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDM1A0.934
ARCN10.934
NRBP10.933
EFTUD20.932
UBE2Z0.931
SND10.931
CSNK2A20.93
SUPT7L0.93
FOXJ30.929
NUP620.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.661
OR4F29-0.611
ASB4-0.287
MTRNR2L6-0.278
MTRNR2L9-0.278
MTRNR2L10-0.27
P2RY14-0.269
KLRB1-0.258
TTLL10-0.247
TBX5-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TRIM27 mRNA"21346803
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to TRIM27 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TRIM27 protein]26598702
C496492abrineabrine results in increased expression of TRIM27 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of TRIM27 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of TRIM27 mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TRIM27 mRNA"23195993
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TRIM27 protein]26598702
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRIM27 mRNA"19150397
C584509C646 compoundC646 compound results in decreased expression of TRIM27 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM27 mRNA20938992
D016572CyclosporineCyclosporine results in increased expression of TRIM27 mRNA20106945|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TRIM27 mRNA21266533
C042080diisodecyl phthalatediisodecyl phthalate results in decreased expression of TRIM27 mRNA25270620
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of TRIM27 mRNA23999411
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TRIM27 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TRIM27 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIM27 mRNA17942748
D005485FlutamideFlutamide results in increased expression of TRIM27 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM27 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of TRIM27 mRNA22061828
D005897GlafenineGlafenine results in increased expression of TRIM27 mRNA24136188
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of TRIM27 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRIM27 mRNA25613284
D007501IronIron deficiency results in increased expression of TRIM27 mRNA16629162
D019266Iron, Dietary"Iron, Dietary affects the expression of TRIM27 mRNA"15637178
C017461lead nitratelead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]11891201
C045463leflunomideleflunomide results in decreased expression of TRIM27 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM27 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRIM27 mRNA23649840
D009532NickelNickel results in decreased expression of TRIM27 mRNA23195993
D010081OxazoloneOxazolone results in increased expression of TRIM27 mRNA23999411
C011272perfosfamideperfosfamide results in decreased expression of TRIM27 mRNA19429390
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRIM27 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of TRIM27 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of TRIM27 mRNA21278054
D012643SeleniumSelenium results in decreased expression of TRIM27 mRNA19244175
D013629TamoxifenTamoxifen affects the expression of TRIM27 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIM27 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRIM27 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TRIM27 mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of TRIM27 mRNA"19682533
C012589trichostatin Atrichostatin A affects the expression of TRIM27 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TRIM27 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of TRIM27 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of TRIM27 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TRIM27 mRNA23179753
D014810Vitamin EVitamin E results in decreased expression of TRIM27 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of TRIM27 mRNA"24525044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-TAS3380101  
GO:0003677DNA binding-IEA-  
GO:0004842ubiquitin-protein transferase activity-IDA22128329  
GO:0004842ubiquitin-protein transferase activity-IMP23452853  
GO:0005515protein binding-IPI9570750  10504338  15837424  16189514  21516116  22128329  
22829933  23452853  25416956  25910212  26871637  27107012  
27107014  
GO:0008270zinc ion binding-IEA-  
GO:0042802identical protein binding-IPI22829933  25416956  27107012  
GO:0046872metal ion binding-TAS3380101  
GO:0061630ubiquitin protein ligase activity-EXP23419514  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10976108  
GO:0002820negative regulation of adaptive immune response-IMP22128329  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006469negative regulation of protein kinase activity-IDA22128329  
GO:0007283spermatogenesis-TAS3380101  
GO:0008283cell proliferation-TAS2734021  
GO:0032720negative regulation of tumor necrosis factor production-IMP22128329  
GO:0032897negative regulation of viral transcription-IDA18248090  
GO:0034314Arp2/3 complex-mediated actin nucleation-IDA23452853  
GO:0042147retrograde transport, endosome to Golgi-IDA23452853  
GO:0045087innate immune response-IDA18248090  
GO:0045814negative regulation of gene expression, epigenetic-IDA10976108  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA23077300  
GO:0051127positive regulation of actin nucleation-IEA-  
GO:0070206protein trimerization-IDA17156811  
GO:0070534protein K63-linked ubiquitination-IMP23452853  
GO:0072643interferon-gamma secretion-IMP22128329  
GO:0090281negative regulation of calcium ion import-IMP22128329  
GO:1900041negative regulation of interleukin-2 secretion-IMP22128329  
GO:1902187negative regulation of viral release from host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA17156811  
GO:0005654nucleoplasm-IDA10976108  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA17156811  
GO:0005768endosome-IDA23452853  
GO:0005769early endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0016605PML body-IEA-  
GO:0030904retromer complexcolocalizes_withIDA23452853  
GO:0031965nuclear membrane-IDA10976108  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29299071Lung function discordance in monozygotic twins and associated differences in blood DNA methylation. (2017)Bolund ACSClin Epigenetics