Gene: BCL2L2

599
BCL-W|BCL2-L-2|BCLW|PPP1R51
BCL2 like 2
protein-coding
14q11.2
Ensembl:ENSG00000129473 MIM:601931 Vega:OTTHUMG00000028738 UniprotKB:Q92843
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MFN20.954
SNX120.938
FAM168B0.937
ENSA0.936
FAM219A0.933
KLC10.93
RABEP10.929
VAPB0.929
SERINC10.927
DCTN10.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.771
OR4F5-0.726
GJB2-0.33
RNF135-0.307
PON3-0.301
SIX1-0.3
ARHGEF5-0.299
ALAS2-0.299
KCNJ15-0.299
EGFLAM-0.291

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12340NavitoclaxSmall Molecule923564-51-6InvestigationalTarget
ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea results in increased expression of BCL2L2 mRNA"23384965
C0389831,3-dimethylthiourea"IL6 gene mutant form inhibits the reaction [1,3-dimethylthiourea results in increased expression of BCL2L2 mRNA]"23384965
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BCL2L2 mRNA"27589474
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2L2 mRNA"27291303
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BCL2L2 mRNA"21346803
C4843272'-benzoyloxycinnamaldehyde2'-benzoyloxycinnamaldehyde results in decreased expression of BCL2L2 protein14660655
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BCL2L2 mRNA"18648102
C501332ABT-737ABT-737 binds to BCL2L2 protein23353698
C501332ABT-737ABT-737 inhibits the reaction [BCL2L2 protein results in decreased susceptibility to Erlotinib Hydrochloride]23894143
D000082AcetaminophenAcetaminophen affects the expression of BCL2L2 mRNA25704631
D000082Acetaminophen[saikosaponin co-treated with Acetaminophen] results in decreased expression of BCL2L2 mRNA25265579
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BCL2L2 mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of BCL2L2 mRNA18585445
C006632arsenic trioxide[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein27430728
C006632arsenic trioxidearsenic trioxide results in increased expression of BCL2L2 protein27430728
C006632arsenic trioxidearsenic trioxide results in decreased expression of BCL2L2 mRNA19730151
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of BCL2L2 mRNA"23634900
D001205Ascorbic Acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of BCL2L2 mRNA17917374
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of BCL2L2 mRNA18585445
D001280AtrazineAtrazine results in decreased expression of BCL2L2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of BCL2L2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of BCL2L2 mRNA22641617
C006780bisphenol Abisphenol A results in decreased expression of BCL2L2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of BCL2L2 protein21277958
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL2L2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of BCL2L2 mRNA25181051
C115950bornyl caffeatebornyl caffeate results in decreased expression of BCL2L224907532
D000069286BortezomibBortezomib results in increased expression of BCL2L2 mRNA18928586
D002104CadmiumCadmium results in decreased expression of BCL2L2 protein25388156
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BCL2L2 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BCL2L2 protein12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BCL2L2 protein19887573
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BCL2L2 mRNA15501611
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BCL2L2 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of BCL2L2 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of BCL2L2 mRNA19376846
D003474Curcumin[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein27430728
D003474CurcuminCurcumin results in increased expression of BCL2L2 mRNA16101141
D003520CyclophosphamideCyclophosphamide results in increased expression of BCL2L2 mRNA21041162
D016572CyclosporineCyclosporine results in increased expression of BCL2L2 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of BCL2L2 mRNA23640034
D013759DronabinolDronabinol results in decreased expression of BCL2L2 mRNA16039398
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL2L2 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of BCL2L2 mRNA21041162
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BCL2L2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BCL2L2 mRNA21266533
D002945Cisplatin[Cisplatin results in increased expression of MIR630] which results in decreased expression of BCL2L2 mRNA21274007
D002945CisplatinCisplatin results in increased expression of BCL2L2 mRNA23384965
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of BCL2L2 mRNA21384494
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of BCL2L2 mRNA17917374
C472036dihydromyricetindihydromyricetin results in decreased expression of BCL2L2 protein27539140
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of BCL2L2 mRNA23894143
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of BCL2L2 protein23894143
D000069347Erlotinib HydrochlorideNiclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]23894143
D000069347Erlotinib Hydrochloride[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride23894143
D000069347Erlotinib HydrochlorideABT-737 inhibits the reaction [BCL2L2 protein results in decreased susceptibility to Erlotinib Hydrochloride]23894143
D000069347Erlotinib HydrochlorideBCL2L2 protein results in decreased susceptibility to Erlotinib Hydrochloride23894143
D005047EtoposideBCL2L2 results in decreased susceptibility to Etoposide14973057
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BCL2L2 mRNA20938992
D005665FurosemideFurosemide affects the expression of BCL2L2 mRNA17497460
C002469fusarenon-Xfusarenon-X results in increased expression of BCL2L2 mRNA24983900
D005839GentamicinsGentamicins results in increased expression of BCL2L2 mRNA18172885
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL2L2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL2L2 mRNA28628672
D007530IsofluraneIsoflurane results in decreased expression of BCL2L2 mRNA16978161
C544151jinfukangjinfukang results in increased expression of BCL2L2 mRNA27392435
C410337K 7174K 7174 results in increased expression of BCL2L2 mRNA24086573
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of BCL2L2 mRNA17917374
D008694MethamphetamineMethamphetamine results in increased expression of BCL2L2 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BCL2L2 mRNA20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of BCL2L2 protein10809232
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of BCL2L2 mRNA26364587
D0156551-Methyl-4-phenylpyridiniumINS protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2L2 mRNA]26364587
D008999MonocrotophosMonocrotophos results in decreased expression of BCL2L2 mRNA20957986|2144529
D008999MonocrotophosMonocrotophos results in decreased expression of BCL2L2 protein21445290
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BCL2L2 mRNA"23634900
C528561navitoclaxnavitoclax binds to BCL2L2 protein23353698
C022838nickel chloridenickel chloride affects the expression of BCL2L2 mRNA22546817
D009534NiclosamideNiclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]23894143
D009534Niclosamide[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride23894143
D009534NiclosamideNiclosamide results in decreased expression of BCL2L2 protein23894143
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of BCL2L2 mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of BCL2L2 mRNA"22937105
D008939MitotaneMitotane results in increased expression of BCL2L2 mRNA23485034
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein24557422
D010100Oxygenresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein]24557422
D010100Oxygensalvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein]24557422
D010100OxygenSIRT1 mutant form promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein]24557422
D010269ParaquatGPX1 protein affects the reaction [Paraquat affects the expression of BCL2L2 mRNA]12654481
D052638Particulate MatterParticulate Matter results in increased expression of BCL2L2 mRNA24216475
D011794QuercetinQuercetin results in increased expression of BCL2L2 mRNA21632981
D012116Resins, Plant"Resins, Plant results in decreased expression of BCL2L2 protein"27268964
C059514resveratrolresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein]24557422
C059514resveratrolresveratrol results in increased expression of BCL2L2 mRNA22748497|2297190
D012402RotenoneRotenone results in decreased expression of BCL2L2 mRNA23186747
C025759saikosaponin[saikosaponin co-treated with Acetaminophen] results in decreased expression of BCL2L2 mRNA25265579
C025759saikosaponinsaikosaponin results in increased expression of BCL2L2 mRNA25265579
C018381salvinsalvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein]24557422
D012834SilverSilver results in decreased expression of BCL2L2 mRNA21611810
D012839SimazineSimazine results in decreased expression of BCL2L2 mRNA25461544
C028982sodium chromate(VI)sodium chromate(VI) results in decreased expression of BCL2L2 mRNA14971655
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCL2L2 mRNA16039398
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCL2L2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCL2L2 mRNA14718646|1597263
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of BCL2L2 mRNA19323979
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of BCL2L2 protein19323979
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of BCL2L2 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BCL2L2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of BCL2L2 mRNA16149072
C057693troglitazonetroglitazone results in decreased expression of BCL2L2 protein16149072
D014415TunicamycinTunicamycin results in increased expression of BCL2L2 mRNA22378314
C000592878UMI-77UMI-77 analog binds to BCL2L2 protein24019208
C000592878UMI-77UMI-77 binds to BCL2L2 protein24019208
D014635Valproic AcidValproic Acid affects the expression of BCL2L2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of BCL2L2 gene29154799
D014635Valproic AcidBCL2L2 protein results in decreased susceptibility to Valproic Acid19060243
D014635Valproic AcidValproic Acid affects the expression of BCL2L2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased expression of BCL2L2 mRNA24216475
C111237vorinostatBCL2L2 protein results in decreased susceptibility to vorinostat19060243
C451735WP 744WP 744 results in decreased expression of BCL2L2 protein15555623
C088658zoledronic acidzoledronic acid results in increased expression of BCL2L2 mRNA19036117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9430630  15694340  16697956  17289999  18448430  18719108  
18981409  21199865  22000515  23055042  25416956  27107012  
GO:0042802identical protein binding-IPI22000515  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0046982protein heterodimerization activity-IBA21873635  
GO:0046982protein heterodimerization activity-IMP16645638  
GO:0051400BH domain binding-IEA-  
GO:0097718disordered domain specific binding-IPI16645638  
GO ID GO Term Qualifier Evidence PubMed
GO:0007283spermatogenesis-TAS8761287  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP17289999  
GO:0060011Sertoli cell proliferation-IEA-  
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand-IBA21873635  
GO:2001243negative regulation of intrinsic apoptotic signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-IBA21873635  
GO:0005829cytosol-IEA-  
GO:0097136Bcl-2 family protein complex-IMP16645638  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28700107Cigarette smoke induces rat testicular injury via mitochondrial apoptotic pathway. (2017 Oct)He LMol Reprod Dev