Gene: RFX2

5990
-
regulatory factor X2
protein-coding
19p13.3
Ensembl:ENSG00000087903 MIM:142765 Vega:OTTHUMG00000180711 UniprotKB:P48378
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.801e-1 (AD)  5.914e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAX60.901
SMO0.901
NHSL10.89
SOX90.889
EYA20.884
CDC42EP40.883
GLI30.881
PHF21B0.881
PRDM160.878
CHDH0.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD5-0.518
KCNK2-0.505
QRFPR-0.495
TYRP1-0.494
NRG1-0.492
ENPP6-0.491
HTR7-0.49
CRHBP-0.487
RAB3B-0.484
SLC7A14-0.48

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RFX2 mRNA29067470
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RFX2 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RFX2 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of RFX2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of RFX2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RFX2 mRNA25181051
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of RFX2 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RFX2 gene20938992
D003300CopperCopper deficiency results in increased expression of RFX2 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of RFX2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of RFX2 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RFX2 mRNA23640034
D002945CisplatinCisplatin results in decreased expression of RFX2 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of RFX2 mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RFX2 gene20938992
D017313FenretinideFenretinide results in decreased expression of RFX2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of RFX2 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of RFX2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RFX2 mRNA25613284
C042720mercuric bromidemercuric bromide results in decreased expression of RFX2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RFX2 gene20938992
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RFX2 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of RFX2 mRNA23608068
C059514resveratrolresveratrol results in increased phosphorylation of RFX2 protein25311616
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RFX2 mRNA25895662
D013629TamoxifenTamoxifen results in increased expression of RFX2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RFX2 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RFX2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RFX2 mRNA25613284
C012589trichostatin Atrichostatin A affects the expression of RFX2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of RFX2 mRNA15901671
D014520UrethaneUrethane results in increased expression of RFX2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RFX2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RFX2 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased expression of RFX2 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RFX2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-TAS8289803  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI16189514  25609649  
GO ID GO Term Qualifier Evidence PubMed
GO:0001675acrosome assembly-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-ISS-  
GO:0007286spermatid development-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0060271cilium assembly-ISS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23009827Effect of cigarette smoking on human oviductal ciliation and ciliogenesis. (2013 Jan)Pier BFertil Steril