Gene: RFX3

5991
-
regulatory factor X3
protein-coding
9p24.2
Ensembl:ENSG00000080298 MIM:601337 Vega:OTTHUMG00000019456 UniprotKB:P48380
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.781e-1 (AD)  8.620e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOB1B0.849
NR3C20.813
DOCK40.809
NCOA20.803
DYNC2H10.8
CROT0.796
ATL20.787
TMEM560.786
HS2ST10.786
CCNG20.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.437
OR4F29-0.384
GNG8-0.34
IL7R-0.313
ANXA13-0.312
S1PR5-0.31
CTNNA3-0.305
FXYD4-0.302
CSAG1-0.297
PGF-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of RFX3 mRNA"20519331
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RFX3 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RFX3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RFX3 mRNA29067470
D001151ArsenicArsenic results in decreased expression of RFX3 mRNA16835338
D001280AtrazineAtrazine results in increased expression of RFX3 mRNA25929836
D001280AtrazineAtrazine results in increased expression of RFX3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RFX3 mRNA19770486
C006780bisphenol Abisphenol A affects the methylation of RFX3 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of RFX3 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of RFX3 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of RFX3 mRNA20106945|2556210
D003976DiazinonDiazinon results in increased methylation of RFX3 gene22964155
D004041Dietary FatsDietary Fats results in decreased expression of RFX3 mRNA25016146
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of RFX3 mRNA24834073
C118739entinostatentinostat results in decreased expression of RFX3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RFX3 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RFX3 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RFX3 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of RFX3 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of RFX3 mRNA19167457
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RFX3 mRNA24796395
D007854LeadLead affects the splicing of RFX3 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of RFX3 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RFX3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RFX3 mRNA23649840
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RFX3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RFX3 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of RFX3 mRNA24780913
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of RFX3 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RFX3 mRNA"26179874
D014520UrethaneUrethane results in increased expression of RFX3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of RFX3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of RFX3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RFX3 gene25560391
D015032ZincZinc deficiency results in increased expression of RFX3 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-TAS8600444  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-NAS8600444  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-TAS8289803  
GO:0005515protein binding-IPI16189514  20148032  21516116  25416956  25609649  27173435  
GO:0044212transcription regulatory region DNA binding-IDA20148032  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0031018endocrine pancreas development-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12411430  
GO:0045893positive regulation of transcription, DNA-templated-IDA20148032  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS20413507  
GO:0048469cell maturation-ISS20413507  
GO:0050796regulation of insulin secretion-ISS20413507  
GO:0060271cilium assembly-ISS20413507  
GO:0060285cilium-dependent cell motility-ISS-  
GO:0060287epithelial cilium movement involved in determination of left/right asymmetry-ISS-  
GO:0072560type B pancreatic cell maturation-IEA-  
GO:2000078positive regulation of type B pancreatic cell development-ISS20413507  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA20413507  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC12411430  
GO:0005667transcription factor complex-IC20413507  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23009827Effect of cigarette smoking on human oviductal ciliation and ciliogenesis. (2013 Jan)Pier BFertil Steril