Gene: RFX4

5992
NYD-SP10
regulatory factor X4
protein-coding
12q23.3
Ensembl:ENSG00000111783 MIM:603958 Vega:OTTHUMG00000169173 UniprotKB:Q33E94
NG_047074.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.060e-2 (AD)  5.223e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRIG10.924
FGF20.918
F30.918
MRVI10.914
ITPKB0.909
BMPR1B0.9
ALDH1L10.896
SOX90.895
TP53BP20.893
NPAS30.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.567
ABCC12-0.567
CALHM1-0.557
ZNF860-0.553
TYRP1-0.551
CNTN6-0.547
SAMD5-0.545
PPEF1-0.539
MYOZ3-0.536
MCHR1-0.534

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RFX4 mRNA"28903501
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of RFX4 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RFX4 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of RFX4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RFX4 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RFX4 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of RFX4 mRNA23557687
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of RFX4 mRNA26496021
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of RFX4 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of RFX4 mRNA20938992
D003300CopperCopper results in decreased expression of RFX4 mRNA26293553
C030973cupric oxidecupric oxide results in increased phosphorylation of RFX4 protein25470785
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of RFX4 mRNA23640034
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RFX4 mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of RFX4 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of RFX4 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of RFX4 mRNA24535843
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of RFX4 mRNA27776689
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of RFX4 mRNA20938992
D004397FonofosFonofos results in increased methylation of RFX4 promoter22847954
C039281furanfuran results in decreased expression of RFX4 mRNA24183702
C000625835HFPO2 compoundHFPO2 compound results in increased expression of RFX4 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of RFX4 mRNA27553808
D006918HydroxyureaHydroxyurea results in increased mutagenesis of RFX4 gene16868089
D007052IbuprofenIbuprofen results in increased expression of RFX4 mRNA28201806
C042720mercuric bromidemercuric bromide results in decreased expression of RFX4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RFX4 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of RFX4 mRNA20938992
D008752Methylene ChlorideMethylene Chloride results in decreased expression of RFX4 mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RFX4 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RFX4 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RFX4 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in increased mutagenesis of RFX4 gene16868089
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RFX4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RFX4 mRNA"25620056
D000073878Palm OilPalm Oil affects the expression of RFX4 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RFX4 mRNA26272509
D010278ParathionParathion results in increased methylation of RFX4 promoter22847954
D010634PhenobarbitalPhenobarbital results in decreased expression of RFX4 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of RFX4 mRNA18301758|2381119
D012834SilverSilver results in decreased expression of RFX4 mRNA26551752
C017947sodium arsenitesodium arsenite affects the methylation of RFX4 gene28589171
C013698tallowtallow affects the expression of RFX4 mRNA19680557
C012568terbufosterbufos results in increased methylation of RFX4 promoter22847954
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of RFX4 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RFX4 mRNA28922406
D014241TrichloroethyleneTrichloroethylene results in increased expression of RFX4 mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RFX4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RFX4 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of RFX4 mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased expression of RFX4 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of RFX4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of RFX4 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RFX4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16893423  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16893423  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI22458338  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0021516dorsal spinal cord development-IEA-  
GO:0021537telencephalon development-IEA-  
GO:0021696cerebellar cortex morphogenesis-IEA-  
GO:0021914negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning-IBA21873635  
GO:0030901midbrain development-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16893423  
GO:0070613regulation of protein processing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21547531Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. (2012 Feb)Wang KSJ Mol Neurosci