Gene: RGS1

5996
1R20|BL34|HEL-S-87|IER1|IR20
regulator of G protein signaling 1
protein-coding
1q31.2
Ensembl:ENSG00000090104 MIM:600323 Vega:OTTHUMG00000035598 UniprotKB:Q08116
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.478e-1 (AD)  7.199e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06357908chr1:192548609RGS13'UTR4.960e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C5AR10.818
GPR1830.818
OLR10.787
TNFRSF1B0.783
B4GALT10.777
CXCL160.767
PTPN60.765
RAB200.765
IFI300.764
SRGN0.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.42
ZNF835-0.417
CALHM1-0.406
NEUROD6-0.4
KIT-0.399
HNF1A-0.396
WNT7A-0.392
MYADML2-0.387
MAGIX-0.381
ABCC12-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RGS1 mRNA"25614096
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RGS1 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RGS1 mRNA19191707
C0297284-phenylenediamine4-phenylenediamine results in increased expression of RGS1 mRNA20713136
D000082AcetaminophenAcetaminophen affects the expression of RGS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RGS1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of RGS1 mRNA"23195993
D0150812-Naphthylamine2-Naphthylamine results in increased expression of RGS1 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RGS1 mRNA24449571
D001151ArsenicArsenic affects the expression of RGS1 mRNA18414638
D001151ArsenicArsenic results in decreased expression of RGS1 mRNA16835338
D001151ArsenicRGS1 mRNA results in decreased susceptibility to Arsenic17976673
C015001arsenitearsenite results in decreased expression of RGS1 mRNA18191166
D001554BenzeneBenzene results in decreased expression of RGS1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGS1 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGS1 mRNA22228805
D004958EstradiolEstradiol affects the expression of RGS1 mRNA23557687
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of RGS1 mRNA18192240
C006780bisphenol Abisphenol A affects the expression of RGS1 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of RGS1 mRNA25181051
C005563captaxcaptax results in increased expression of RGS1 mRNA20713136
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RGS1 mRNA27339419
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RGS1 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS1 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of RGS1 mRNA27523638
D003561CytarabineCytarabine results in decreased expression of RGS1 mRNA21198554
D003703DemecolcineDemecolcine results in increased expression of RGS1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RGS1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of RGS1 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of RGS1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of RGS1 mRNA22609946|2501614
D002117CalcitriolCalcitriol results in decreased expression of RGS1 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of RGS1 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of RGS1 mRNA17374397
D004317DoxorubicinDoxorubicin affects the expression of RGS1 mRNA15205334
D004391DustDust results in increased expression of RGS1 mRNA17805423
D005054EugenolEugenol results in increased expression of RGS1 mRNA17374397|2071313
D005472FluorouracilFluorouracil affects the expression of RGS1 mRNA15205334
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of RGS1 mRNA23649840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RGS1 mRNA24763279
D019807Iodoacetic Acid[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA18624922
D019807Iodoacetic AcidOctreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]18624922
D019807Iodoacetic AcidSSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]18624922
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RGS1 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of RGS1 mRNA15956246
C051890irinotecanirinotecan results in increased expression of RGS1 mRNA15956246
D007501IronIron deficiency results in increased expression of RGS1 mRNA20368581
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of RGS1 mRNA17085751
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RGS1 mRNA21949397|2308692
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RGS1 mRNA27339419
D015122MercaptopurineMercaptopurine results in increased expression of RGS1 mRNA23358152
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of RGS1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of RGS1 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS1 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of RGS1 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RGS1 mRNA23179753
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RGS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RGS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RGS1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of RGS1 mRNA19812364
D009532NickelNickel results in increased expression of RGS1 mRNA23195993|2476865
C028007nickel monoxidenickel monoxide results in increased expression of RGS1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of RGS1 mRNA16780908|1737439
D009538NicotineNicotine results in increased expression of RGS1 mRNA18247414
D009584Nitrogen[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA18624922
D009584NitrogenOctreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]18624922
D009584NitrogenSSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]18624922
D015282OctreotideOctreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]18624922
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RGS1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of RGS1 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of RGS1 mRNA17374397
C016030pantogabpantogab results in increased expression of RGS1 mRNA17379144
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of RGS1 mRNA27153767
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of RGS1 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of RGS1 mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of RGS1 mRNA22238285
D011794QuercetinQuercetin results in increased expression of RGS1 mRNA15309432
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of RGS1 mRNA19564919
C534628SCH 23390SCH 23390 affects the expression of RGS1 mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in increased expression of RGS1 mRNA19073995
D012822Silicon DioxideSilicon Dioxide results in increased expression of RGS1 mRNA22431001
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of RGS1 mRNA20713136
D053260SootSoot results in increased expression of RGS1 mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS1 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGS1 mRNA26290441
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RGS1 mRNA25613284
C009495titanium dioxidetitanium dioxide analog results in decreased expression of RGS1 mRNA25111187
C009495titanium dioxidetitanium dioxide results in increased expression of RGS1 mRNA19464567|2125934
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RGS1 mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RGS1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RGS1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of RGS1 mRNA25729387
D014635Valproic AcidValproic Acid results in decreased methylation of RGS1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RGS1 gene25560391
D014750VincristineVincristine results in increased expression of RGS1 mRNA23649840
D014807Vitamin DVitamin D affects the expression of RGS1 mRNA20368581
D019287Zinc SulfateZinc Sulfate results in decreased expression of RGS1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IPI18434541  
GO:0005096GTPase activator activity-IDA10480894  18434541  
GO:0005516calmodulin binding-TAS10747990  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS8241276  
GO:0007165signal transduction-IDA10480894  
GO:0007186G-protein coupled receptor signaling pathway-IDA10480894  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS10480894  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IDA10480894  18434541  
GO:0061737leukotriene signaling pathway-IDA10480894  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA10480894  
GO:0005886plasma membrane-TAS10480894  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA10480894  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22363809Monocyte gene expression signature of patients with early onset coronary artery disease. (2012)Sivapalaratnam SPLoS One