Gene: RGS4

5999
RGP4|SCZD9
regulator of G protein signaling 4
protein-coding
1q23.3
Ensembl:ENSG00000117152 MIM:602516 Vega:OTTHUMG00000034417 UniprotKB:P49798
NG_023312.1
PubMed
0   ANCO-SNPs
OD|CD|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.007e-1 (AD)  7.183e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRA10.977
NCALD0.975
ENC10.971
PAK10.969
GABBR20.967
DLGAP10.965
PRKCE0.965
SYT10.964
RASGRF10.963
OPCML0.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAP1-0.555
ARHGEF5-0.541
HEY2-0.538
RNF135-0.534
MYL3-0.533
REST-0.527
WWTR1-0.527
CSAG1-0.527
RHOD-0.525
LRAT-0.523

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RGS4 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS4 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of RGS4 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RGS4 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RGS4 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS4 mRNA16483693
D003913DextroamphetamineDextroamphetamine promotes the reaction [eticlopride results in decreased expression of RGS4 mRNA]16539683
D003913DextroamphetamineDextroamphetamine promotes the reaction [SCH 23390 results in increased expression of RGS4 mRNA]16539683
D003913DextroamphetamineDextroamphetamine results in decreased expression of RGS4 mRNA12270694|1653968
D003913DextroamphetamineDextroamphetamine results in decreased expression of RGS4 protein16539683
D003913DextroamphetamineDextroamphetamine results in increased expression of RGS4 mRNA12270694
D000661AmphetamineAmphetamine results in decreased expression of RGS4 mRNA12638131
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of RGS4 mRNA"17331233
D001379AzathioprineAzathioprine results in decreased expression of RGS4 mRNA19192274
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RGS4 mRNA18164116
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of RGS4 mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of RGS4 mRNA21179406
C452139BIRB 796BIRB 796 results in increased expression of RGS4 mRNA24303162
C006780bisphenol Abisphenol A affects the expression of RGS4 mRNA21786754|2355768
C006780bisphenol Abisphenol A results in decreased expression of RGS4 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of RGS4 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of RGS4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RGS4 gene28505145
D002104CadmiumCadmium results in increased expression of RGS4 mRNA21172416
D002118CalciumRGS4 protein inhibits the reaction [PTAFR protein affects the localization of and affects the abundance of Calcium]11297424
D002737ChloropreneChloroprene results in decreased expression of RGS4 mRNA23125180
D003024ClozapineClozapine results in increased expression of RGS4 mRNA17266109
D003024ClozapineClozapine results in increased expression of RGS4 mRNA15860345
C018021cobaltous chloridecobaltous chloride results in decreased expression of RGS4 mRNA19320972
D003042CocaineCocaine affects the expression of RGS4 mRNA17632279|2018794
D003042CocaineCocaine results in decreased expression of RGS4 mRNA12270694
D003042CocaineCocaine results in increased expression of RGS4 mRNA12270694
D003474CurcuminCurcumin results in decreased expression of RGS4 mRNA21594647
D003561CytarabineCytarabine results in decreased expression of RGS4 mRNA21198554
D000069439DasatinibDasatinib results in decreased expression of RGS4 mRNA20579391
D003907DexamethasoneDexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]21149847
D003976DiazinonDiazinon results in increased expression of RGS4 mRNA29108742
C016366dibenzothiophenedibenzothiophene results in increased expression of RGS4 mRNA23656968
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of RGS4 mRNA28962523
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of RGS4 mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of RGS4 mRNA19561079
D004008DiclofenacDiclofenac results in decreased expression of RGS4 mRNA19192274
D004041Dietary FatsDietary Fats results in increased expression of RGS4 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of RGS4 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RGS4 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of RGS4 mRNA21658437
D004178DiquatDiquat results in increased expression of RGS4 mRNA21172416
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RGS4 mRNA22079256
C045989eticloprideDextroamphetamine promotes the reaction [eticlopride results in decreased expression of RGS4 mRNA]16539683
C045989eticloprideeticlopride results in decreased expression of RGS4 mRNA16539683
C045989eticloprideeticlopride results in decreased expression of RGS4 protein16539683
D005419FlavonoidsFlavonoids results in increased expression of RGS4 mRNA18035473
D005472FluorouracilRGS4 protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in decreased expression of RGS4 mRNA28937961
D005620Freund's AdjuvantDexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]21149847
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of RGS4 mRNA21149847
D005620Freund's AdjuvantPrednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]21149847
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of RGS4 mRNA19192274
D006220HaloperidolHaloperidol results in increased expression of RGS4 mRNA15860345
D017313FenretinideFenretinide results in decreased expression of RGS4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of RGS4 mRNA28973697
C051890irinotecanirinotecan results in increased expression of RGS4 mRNA20097248
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RGS4 mRNA24796395|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RGS4 mRNA26644586
C119620kenpaullonekenpaullone results in decreased expression of RGS4 mRNA17993264
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RGS4 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS4 mRNA]16415329
D018021Lithium ChlorideLithium Chloride results in increased expression of RGS4 mRNA15711924
D018021Lithium ChlorideLithium Chloride results in increased expression of RGS4 protein15711924
D008694MethamphetamineMethamphetamine affects the expression of RGS4 mRNA19126440
D008727MethotrexateMethotrexate results in decreased expression of RGS4 mRNA17400583|1919227
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RGS4 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RGS4 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RGS4 mRNA"20188158
D008775MethylprednisoloneMethylprednisolone results in decreased expression of RGS4 mRNA19192274
D008777MethyltestosteroneMethyltestosterone results in increased expression of RGS4 mRNA29191790
D009020MorphineMorphine results in decreased expression of RGS4 mRNA12270694
D009020MorphineMorphine results in increased expression of RGS4 mRNA12270694
C523799MRK 003RGS4 results in decreased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in increased expression of RGS4 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RGS4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RGS4 mRNA"25554681
C025256nonylphenolnonylphenol results in increased expression of RGS4 mRNA22982499
C558013NSC 689534NSC 689534 results in increased expression of RGS4 mRNA20971185
C030110oxaliplatinoxaliplatin results in decreased expression of RGS4 mRNA17762391
D010100OxygenOxygen deficiency results in decreased expression of RGS4 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of RGS4 mRNA20880076
D000073878Palm OilPalm Oil results in increased expression of RGS4 mRNA18042831
D010269ParaquatParaquat results in increased expression of RGS4 mRNA18198484
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of RGS4 mRNA26705709
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of RGS4 mRNA28973697
D010622PhencyclidinePhencyclidine results in increased expression of RGS4 mRNA17266109
D010634PhenobarbitalPhenobarbital affects the expression of RGS4 mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of RGS4 mRNA24535843
D010656PhenylephrineRGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]18977218
D010656PhenylephrineRGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]18977218
D010712Phosphatidic AcidsPhosphatidic Acids affects the folding of RGS4 protein12538649
D010712Phosphatidic AcidsPhosphatidic Acids results in decreased activity of RGS4 protein12538649
D010716PhosphatidylinositolsRGS4 protein inhibits the reaction [PTAFR protein results in increased hydrolysis of Phosphatidylinositols]11297424
D010758PhosphorusPhosphorus results in decreased expression of RGS4 mRNA17715259
C006253pirinixic acidpirinixic acid results in decreased expression of RGS4 mRNA16985257
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of RGS4 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of RGS4 mRNA19192274|2185817
D010972Platelet Activating FactorRGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]11297424
D011070Poly I-CPoly I-C results in increased expression of RGS4 mRNA24889602
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RGS4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RGS4 mRNA22079256|2271453
D011239PrednisolonePrednisolone results in decreased expression of RGS4 mRNA19192274
D011239PrednisolonePrednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]21149847
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of RGS4 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of RGS4 mRNA20864642|2179573
D011441PropylthiouracilPropylthiouracil results in decreased expression of RGS4 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RGS4 mRNA19059307
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RGS4 mRNA19059307
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS4 mRNA]16415329
D012110ReserpineReserpine results in decreased expression of RGS4 mRNA14505795
C059514resveratrolresveratrol results in increased expression of RGS4 mRNA25905778
C089730rosiglitazonerosiglitazone results in increased expression of RGS4 mRNA21515302
D012524SarinSarin results in decreased expression of RGS4 mRNA19522546
C534628SCH 23390Dextroamphetamine promotes the reaction [SCH 23390 results in increased expression of RGS4 mRNA]16539683
C534628SCH 23390SCH 23390 affects the expression of RGS4 protein16539683
C534628SCH 23390SCH 23390 results in increased expression of RGS4 mRNA16539683
D012715Sesame OilSesame Oil results in decreased expression of RGS4 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RGS4 mRNA22431001
C017947sodium arsenitesodium arsenite results in decreased expression of RGS4 mRNA25493608
D012999SomanSoman results in increased expression of RGS4 mRNA19281266
D013605T-2 ToxinT-2 Toxin results in increased expression of RGS4 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of RGS4 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of RGS4 mRNA19059307
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of RGS4 mRNA19059307
C501413tesaglitazartesaglitazar results in increased expression of RGS4 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RGS4 mRNA18691609
D013755Tetradecanoylphorbol AcetateRGS4 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTAFR protein]11297424
D013999TimololRGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]18977218
D013999TimololRGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]18977218
D014212TretinoinTretinoin results in increased expression of RGS4 mRNA20530235
D014212TretinoinTretinoin results in increased expression of RGS4 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of RGS4 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RGS4 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RGS4 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of RGS4 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of RGS4 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of RGS4 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of RGS4 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RGS4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RGS4 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of RGS4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of RGS4 mRNA23665938
D014638VanadatesVanadates results in increased expression of RGS4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RGS4 gene25560391
C025643vinclozolinvinclozolin affects the expression of RGS4 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of RGS4 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS4 mRNA"27188386
D015034Zinc OxideZinc Oxide analog results in decreased expression of RGS4 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of RGS4 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IEA-  
GO:0005516calmodulin binding-TAS10747990  
GO ID GO Term Qualifier Evidence PubMed
GO:0000188inactivation of MAPK activity-TAS8602223  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS10747990  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10791963  
GO:0005737cytoplasm-IDA10791963  
GO:0005829cytosol-IEA-  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22056472Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. (2012 Feb)Rivero GNeuropharmacology
17880927A role of RGS proteins in drug addiction. (2008 Jan 1)Hooks SBBiochem Pharmacol
20430014Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. (2010 Jun 22)Ho AMBrain Res
14534355A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. (2003 Dec)Carrasco GAJ Pharmacol Exp Ther