Gene: ACTB

60
BRWS1|PS1TP5BP1
actin beta
protein-coding
7p22.1
Ensembl:ENSG00000075624 MIM:102630 Vega:OTTHUMG00000023268 UniprotKB:P60709
NG_007992.1
PubMed
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.435e-1 (AD)  7.791e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01741041chr7:5567862ACTB2.150e-10Maternal smoking in pregnancy27040690
cg14145074chr7:5567891ACTB1.870e-8Maternal smoking in pregnancy27040690
cg01741041chr7:5567862ACTB1.970e-8Maternal smoking in pregnancy27040690
cg05971148chr7:5568411ACTB6.500e-12Smoking27651444
cg14145074chr7:5567891ACTB1.020e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACTG10.972
CSNK2B0.962
RAB7A0.957
HNRNPD0.954
GAPDH0.953
PCBP20.952
PSMB40.952
PHB20.951
MRFAP10.945
CAPZB0.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.908
OR4F29-0.894
MTRNR2L6-0.137
HMHB1-0.132
MTRNR2L9-0.123
OR6C74-0.119
LCE3B-0.098
PRDM14-0.097
CCR8-0.095
FANCD2OS-0.095

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0810141,2-bis(2,4,6-tribromophenoxy)ethane"1,2-bis(2,4,6-tribromophenoxy)ethane results in increased expression of ACTB mRNA"28249227
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to ACTB protein16453347
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ACTB mRNA"21346803
C0247092,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to ACTB protein"16533022
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTB mRNA"15215175
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone affects the expression of ACTB mRNA"20206263
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of ACTB mRNA"12734338
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ACTB mRNA12958071
C0275764-hydroxy-2-nonenalACTB protein binds to 4-hydroxy-2-nonenal20043646
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ACTB mRNA20829426
C0114215-chloro-2-methyl-4-isothiazolin-3-one5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ACTB protein29267982
C048324abamectinabamectin results in decreased expression of ACTB protein19879343
D000082AcetaminophenAcetaminophen affects the expression of ACTB mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of ACTB mRNA20732408
D000082AcetaminophenAcetaminophen results in increased expression of ACTB mRNA22563491
D000082AcetaminophenAcetaminophen results in increased expression of ACTB protein16687475
D019342Acetic AcidAcetic Acid affects the expression of ACTB protein21296659
D000171AcroleinAcrolein results in increased metabolism of ACTB protein17570602
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ACTB mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACTB mRNA19770486
D000496AlloxanAlloxan results in decreased expression of ACTB mRNA12137914
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of ACTB protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog affects the expression of ACTB protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of ACTB protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ACTB protein26597043
D000499AllylamineAllylamine results in increased expression of ACTB mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of ACTB mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of ACTB protein16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of ACTB mRNA12558987
D001151ArsenicArsenic results in decreased expression of ACTB mRNA18315880
C006632arsenic trioxidearsenic trioxide results in decreased expression of ACTB mRNA20458559
C006632arsenic trioxidearsenic trioxide results in decreased expression of ACTB protein20452446
C006632arsenic trioxidearsenic trioxide results in increased expression of ACTB mRNA11940349|2045244
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTB protein]17303692
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA]15477007
C004456beauvericinbeauvericin results in decreased expression of ACTB mRNA29203277
D001554BenzeneBenzene affects the expression of ACTB mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACTB mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACTB protein18495319
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of ACTB protein modified form24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACTB mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACTB mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACTB protein20719421
D001564Benzo(a)pyrene[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of ACTB protein20719421
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACTB mRNA15857753
C044887beta-methylcholinebeta-methylcholine affects the expression of ACTB mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of ACTB mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of ACTB protein25772901
C006780bisphenol Abisphenol A results in increased methylation of ACTB promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ACTB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ACTB gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of ACTB protein28903499
C032036bromobenzenebromobenzene results in increased expression of ACTB mRNA16036859
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of ACTB protein21296659
C022777bufalinbufalin results in increased expression of ACTB protein23091618
D002065BuspironeBuspirone results in decreased expression of ACTB mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of ACTB mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ACTB mRNA12419474
C018475butyraldehydebutyraldehyde results in increased expression of ACTB mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ACTB protein16372273
D019256Cadmium ChlorideCadmium Chloride affects the expression of ACTB protein24874008
D019256Cadmium ChlorideCadmium Chloride affects the expression of ACTB mRNA23828170
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ACTB protein20452446
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ACTB mRNA20452446|2588268
D019256Cadmium ChlorideCadmium Chloride affects the expression of ACTB mRNA18804290
D019256Cadmium Chloride[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of ACTB protein20719421
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ACTB protein20719421
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in increased expression of ACTB mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in increased expression of ACTB mRNA20596552
D002118Calcium[Calcium co-treated with Calcitriol] affects the expression of ACTB mRNA15913539
D002246Carbon DisulfideCarbon Disulfide results in increased expression of ACTB mRNA17498345
D002246Carbon DisulfideCarbon Disulfide results in increased expression of ACTB protein16474999|1749834
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ACTB mRNA18395095
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ACTB protein18395095
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ACTB mRNA22563491
D002251Carbon Tetrachloride[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of ACTB protein25303780
D002273CarcinogensCarcinogens results in increased expression of ACTB mRNA16316942
D002392Catechin"Catechin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]"19743802
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ACTB mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ACTB mRNA18804290
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ACTB mRNA18178546
C100187chloropicrinchloropicrin results in decreased expression of ACTB mRNA26352163
C012843cinnamic aldehydecinnamic aldehyde results in increased metabolism of ACTB protein29267982
D002994ClofibrateClofibrate results in decreased expression of ACTB mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ACTB mRNA22300585
D002994ClofibrateClofibrate results in increased expression of ACTB protein16470657
D003033Coal TarCoal Tar results in increased expression of ACTB protein18495319
D019327Copper SulfateCopper Sulfate results in decreased expression of ACTB protein20452446
D019327Copper SulfateCopper Sulfate results in increased expression of ACTB mRNA19549813|2045244
C029892cupric chloridecupric chloride results in decreased expression of ACTB protein22030410
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of ACTB mRNA17383702
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of ACTB mRNA23342045
D003520CyclophosphamideCyclophosphamide results in decreased expression of ACTB mRNA12167460
D003520CyclophosphamideCyclophosphamide affects the expression of ACTB mRNA10859244
D016572CyclosporineCyclosporine results in decreased expression of ACTB mRNA21632981
D016572CyclosporineCyclosporine results in increased secretion of ACTB protein21354196
D003634DDTDDT results in decreased expression of ACTB protein26186133
C007262deoxynivalenoldeoxynivalenol results in increased expression of ACTB mRNA26417708
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA16054899
D003907DexamethasoneTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA]16054899
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of ACTB protein"18495319
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTB mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTB mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ACTB mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ACTB mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ACTB mRNA28302478
D004026DieldrinDieldrin results in decreased expression of ACTB protein20584760
D004026DieldrinDieldrin results in increased expression of ACTB protein20584760
D004041Dietary FatsDietary Fats results in increased expression of ACTB mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ACTB protein28934723
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ACTB protein16400681
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ACTB mRNA15171707
D002117Calcitriol[Calcium co-treated with Calcitriol] affects the expression of ACTB mRNA15913539
D0151023,4-Dihydroxyphenylacetic Acid"3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein"19743802
D0151023,4-Dihydroxyphenylacetic Acid"Catechin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]"19743802
D0151023,4-Dihydroxyphenylacetic Acid"epicatechin gallate inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]"19743802
D0151023,4-Dihydroxyphenylacetic Acid"Quercetin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]"19743802
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of ACTB mRNA"21785161
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased metabolism of ACTB protein29267982
D004298DopamineDopamine affects the expression of ACTB protein24675778
C084101doramectindoramectin results in decreased expression of ACTB protein19879343
D004317DoxorubicinDoxorubicin affects the expression of ACTB protein29385562
D004317DoxorubicinDoxorubicin results in increased oxidation of ACTB protein28818578
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ACTB mRNA20064776
C062669epicatechin gallate"epicatechin gallate inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]"19743802
D000431EthanolEthanol results in decreased expression of ACTB protein23702218
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ACTB mRNA17215170
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ACTB mRNA17288598
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACTB mRNA23550701
C504383fenbuconazolefenbuconazole results in increased expression of ACTB mRNA15942997
D005411Flame RetardantsFlame Retardants results in decreased expression of ACTB protein18550172
D005411Flame RetardantsFlame Retardants results in increased expression of ACTB protein18550172
C024352fludarabine[LAQ824 co-treated with fludarabine] results in increased expression of ACTB mRNA18852132
D005472FluorouracilFluorouracil results in decreased expression of ACTB protein21296659
D005485FlutamideFlutamide results in increased expression of ACTB mRNA24136188
C039281furanfuran results in increased expression of ACTB mRNA15120968
D005688GalactosamineGalactosamine results in increased expression of ACTB mRNA22563491
D019833GenisteinGenistein results in decreased expression of ACTB mRNA22228119
D005839GentamicinsGentamicins results in increased expression of ACTB mRNA22061828
D005947GlucoseGlucose deficiency results in decreased expression of ACTB protein22314686
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of ACTB mRNA22634610
D006820Hyaluronic AcidHyaluronic Acid analog affects the expression of ACTB protein23178681
D006820Hyaluronic AcidHyaluronic Acid analog affects the reaction [Hydrogen Peroxide results in decreased expression of ACTB protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ACTB mRNA12419474
D006861Hydrogen PeroxideHyaluronic Acid analog affects the reaction [Hydrogen Peroxide results in decreased expression of ACTB protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ACTB protein23178681
D002112CalcifediolCalcifediol deficiency results in decreased expression of ACTB mRNA17293106
C474021indirubin-3'-monoximeindirubin-3'-monoxime affects the expression of ACTB protein18958680
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA15477007
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA]16054899
D007545IsoproterenolIsoproterenol results in decreased expression of ACTB mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ACTB mRNA27392435
C410337K 7174K 7174 results in decreased expression of ACTB mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of ACTB mRNA16807920
C477361LAQ824[LAQ824 co-treated with fludarabine] results in increased expression of ACTB mRNA18852132
C037067latrunculin AACTB protein mutant form results in decreased susceptibility to latrunculin A16685646
D007854LeadLead affects the expression of ACTB mRNA28903495
C008261lead acetatelead acetate affects the expression of ACTB protein20797405
C029891lead chloridelead chloride results in decreased expression of ACTB protein24419708
C045463leflunomideleflunomide results in increased expression of ACTB mRNA28988120
D001556LindaneLindane results in decreased expression of ACTB mRNA18804290
D001556LindaneLindane affects the expression of ACTB mRNA22001173
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ACTB mRNA11779202
D008094LithiumLithium results in increased expression of ACTB protein18296634
D008148LovastatinLovastatin results in decreased expression of ACTB mRNA20493250
D008148LovastatinLovastatin results in increased expression of ACTB mRNA20493250
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in decreased expression of ACTB mRNA24525745
C025340manganese chloridemanganese chloride results in decreased expression of ACTB protein20452446
C025340manganese chloridemanganese chloride results in increased expression of ACTB mRNA20452446
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of ACTB protein20452446
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ACTB mRNA20452446
D008628MercuryMercury results in increased expression of ACTB mRNA22688007
D008694MethamphetamineMethamphetamine results in decreased expression of ACTB protein19826936
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ACTB mRNA26272509
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ACTB protein22265609
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ACTB mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ACTB mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in increased mutagenesis of ACTB gene10767621
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ACTB protein24675778
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to ACTB protein]17220478
D015741MetriboloneMetribolone results in increased expression of ACTB protein17152098
D015735MifepristoneMifepristone results in decreased expression of ACTB mRNA17584828
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of ACTB protein20553848
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACTB mRNA"28673683
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ACTB protein"21135415
C000621033napabucasinnapabucasin results in decreased expression of ACTB mRNA25605917
C031721naphthalenenaphthalene metabolite binds to ACTB protein16453347
C031721naphthalenenaphthalene metabolite binds to ACTB protein15892573
C031721naphthalenenaphthalene results in increased expression of ACTB protein19438287
D009532NickelNickel results in increased expression of ACTB mRNA25583101
C119536nickel acetatenickel acetate affects the expression of ACTB mRNA23828170
C022838nickel chloridenickel chloride results in decreased expression of ACTB protein20452446
C022838nickel chloridenickel chloride results in increased expression of ACTB mRNA20452446
C028007nickel monoxidenickel monoxide results in decreased expression of ACTB mRNA19167457
D009538NicotineNicotine results in increased expression of ACTB mRNA17997037
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of ACTB mRNA15878706
D005996NitroglycerinNitroglycerin results in decreased expression of ACTB mRNA12102619
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ACTB mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of ACTB protein19716841
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ACTB protein19716841
C025256nonylphenolnonylphenol results in increased expression of ACTB protein19260726
D000069463Olive Oil[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of ACTB protein25303780
C507134ON 01910ON 01910 results in increased expression of ACTB mRNA22351695
D010100OxygenOxygen deficiency affects the expression of ACTB protein19579223
D010100OxygenOxygen deficiency promotes the reaction [KDM1A protein binds to ACTB promoter]25043185
D010126OzoneOzone results in decreased expression of ACTB mRNA16330353
D010261ParaoxonParaoxon results in increased expression of ACTB protein20931991
D010269ParaquatParaquat results in increased expression of ACTB mRNA20883675
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ACTB protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ACTB protein18550172
C033094perfluorobutyric acidperfluorobutyric acid results in decreased expression of ACTB mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of ACTB mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACTB mRNA]19167519
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ACTB mRNA19167519
C023036perfluorooctanoic acidperfluorooctanoic acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACTB mRNA]19167519
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACTB mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACTB mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACTB protein19616056
C011272perfosfamideperfosfamide results in decreased expression of ACTB mRNA19429390
C058305phenethyl isothiocyanateACTB protein binds to phenethyl isothiocyanate21838287
D010695PhlorhizinPhlorhizin results in increased expression of ACTB mRNA22538082
D010862PilocarpinePilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]16492139
D011374ProgesteroneProgesterone affects the expression of ACTB mRNA17251523
C045950propiconazolepropiconazole results in decreased expression of ACTB mRNA19363144
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of ACTB protein19264907
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA]15477007
D011794QuercetinQuercetin analog binds to ACTB protein mutant form21798748
D011794QuercetinQuercetin results in decreased expression of ACTB mRNA21632981
D011794Quercetin"Quercetin inhibits the reaction [3,4-Dihydroxyphenylacetic Acid analog binds to ACTB protein]"19743802
C502851quinocetonequinocetone results in decreased expression of ACTB protein27046791
C502851quinocetonequinocetone results in increased expression of ACTB protein27046791
C059514resveratrolresveratrol affects the expression of ACTB mRNA15748624
D012176RetinoidsRetinoids results in increased expression of ACTB protein28886987
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA16054899
C089730rosiglitazoneTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA]16054899
D012643SeleniumSelenium results in increased expression of ACTB mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ACTB mRNA"23706555
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of and results in increased phosphorylation of ACTB protein"23706555
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of ACTB protein25895662
D012834SilverSilver results in decreased expression of ACTB mRNA19429238
D012834SilverSilver analog results in decreased expression of ACTB mRNA22727896
D012835Silver NitrateSilver Nitrate results in decreased expression of ACTB mRNA22727896
D019821SimvastatinSimvastatin results in increased expression of ACTB mRNA25055962
D020123Sirolimus[Sirolimus binds to FKBP1A protein] which results in increased expression of ACTB mRNA7503980
D020123SirolimusSirolimus results in increased expression of ACTB mRNA7503980
C009277sodium arsenatesodium arsenate results in increased expression of ACTB mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of ACTB mRNA19590694
C017947sodium arsenitesodium arsenite results in increased expression of ACTB mRNA19072884
D012969Sodium FluorideSodium Fluoride results in decreased expression of ACTB protein27548804
D012969Sodium FluorideSodium Fluoride results in increased expression of ACTB mRNA27862939
D018038Sodium SeleniteSodium Selenite results in increased expression of ACTB mRNA18175754
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of ACTB protein modified form24464499
D053260SootSoot results in decreased expression of ACTB protein24464499
D053260SootSoot results in decreased expression of ACTB protein modified form24464499
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of ACTB mRNA16214533
C016766sulforafanACTB protein binds to sulforafan21838287
D013605T-2 ToxinT-2 Toxin affects the expression of ACTB protein26141394
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide affects the expression of ACTB protein24430359
D013749Tetrachlorodibenzodioxinperfluorooctane sulfonic acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACTB mRNA]19167519
D013749Tetrachlorodibenzodioxinperfluorooctanoic acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACTB mRNA]19167519
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACTB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTB mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACTB mRNA15591033|1869160
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACTB mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACTB mRNA15703262
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACTB mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACTB mRNA16054898|1646670
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ACTB mRNA28973375
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA15477007
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of ACTB protein"25852303
D013853ThioacetamideThioacetamide results in decreased expression of ACTB mRNA18395095
D013853ThioacetamideThioacetamide results in decreased expression of ACTB protein18395095
D013853ThioacetamideThioacetamide results in increased expression of ACTB mRNA22563491
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTB protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTB protein17303692
C009495titanium dioxidetitanium dioxide results in increased expression of ACTB mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased metabolism of ACTB protein23396223
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ACTB mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACTB mRNA28111298
D014212TretinoinTretinoin affects the expression of ACTB protein15789344
C032910triadimefontriadimefon results in decreased expression of ACTB mRNA19363144
D014241TrichloroethyleneTrichloroethylene results in increased expression of ACTB mRNA19254012
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of ACTB mRNA17982090
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of ACTB mRNA12163651
C001899triptolidetriptolide results in decreased expression of ACTB mRNA27554044
C001899triptolidetriptolide results in decreased expression of ACTB protein27554044
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ACTB mRNA29024780
C080163trovafloxacintrovafloxacin results in decreased expression of ACTB mRNA24136188
D014501UraniumUranium affects the expression of ACTB mRNA15672453
D014501UraniumUranium affects the expression of ACTB protein15672453
C005460uranyl acetateuranyl acetate affects the expression of ACTB mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of ACTB protein15672453
D014635Valproic AcidValproic Acid results in increased expression of ACTB mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of ACTB gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ACTB mRNA23665938
D014640VancomycinVancomycin results in increased expression of ACTB mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ACTB protein18495319
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ACTB protein18495319
C025643vinclozolinvinclozolin affects the expression of ACTB mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of ACTB protein20616205
D014800VitalliumVitallium analog results in decreased expression of ACTB mRNA23825117
D014801Vitamin AVitamin A deficiency results in decreased expression of ACTB mRNA12163651
D014810Vitamin EVitamin E results in increased expression of ACTB mRNA19244175
D014859WarfarinWarfarin results in decreased expression of ACTB mRNA20493250
D014859WarfarinWarfarin results in increased expression of ACTB mRNA20493250
D019287Zinc SulfateZinc Sulfate affects the expression of ACTB protein25162517
C028541zirconium oxidezirconium oxide results in increased expression of ACTB mRNA17197017

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0005200structural constituent of cytoskeleton-TAS6202424  
GO:0005515protein binding-IPI11682052  11687588  14592989  15047060  15161933  15328537  
15527767  16189514  16375898  17192268  17342765  17404223  
17502619  17599063  17823310  18331289  18562541  19000816  
19008859  19328794  19338310  20473970  20618440  21044950  
21516116  21555369  21577206  23100250  25416956  25910212  
27107014  
GO:0005524ATP binding-IEA-  
GO:0019894kinesin binding-IPI18680169  
GO:0019901protein kinase binding-IPI24327345  
GO:0030957Tat protein binding-IPI16687403  
GO:0031492nucleosomal DNA bindingcontributes_toHDA16217013  
GO:0042802identical protein binding-IPI16189514  17404223  18234857  19000816  20383143  21516116  
25416956  25910212  
GO:0050998nitric-oxide synthase binding-IPI17502619  
GO:0098973structural constituent of postsynaptic actin cytoskeleton-IDA18341992  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-ISS-  
GO:0001895retina homeostasis-HEP23580065  
GO:0016579protein deubiquitination-TAS-  
GO:0021762substantia nigra development-HEP22926577  
GO:0022898regulation of transmembrane transporter activity-IGI18331289  
GO:0022898regulation of transmembrane transporter activity-ISS18331289  
GO:0032091negative regulation of protein binding-ISS-  
GO:0034329cell junction assembly-TAS-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0043044ATP-dependent chromatin remodeling-HDA16217013  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048870cell motility-IMP6202424  
GO:0051621regulation of norepinephrine uptake-IGI18331289  
GO:0051621regulation of norepinephrine uptake-ISS18331289  
GO:0051623positive regulation of norepinephrine uptake-TAS18331289  
GO:0061024membrane organization-TAS-  
GO:0070527platelet aggregation-HMP23382103  
GO:0072749cellular response to cytochalasin B-IMP6202424  
GO:0098974postsynaptic actin cytoskeleton organization-IDA18341992  
GO:1903076regulation of protein localization to plasma membrane-IMP18331289  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-HDA16217013  
GO:0005615extracellular space-HDA16502470  22664934  23580065  
GO:0005634nucleus-IDA11687588  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA24327345  
GO:0005737cytoplasm-TAS16130169  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IDA24327345  
GO:0005856cytoskeleton-ISS-  
GO:0005856cytoskeleton-TAS16130169  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-IDA11687588  
GO:0016020membrane-HDA19946888  
GO:0031982vesicle-HDA19190083  
GO:0032991protein-containing complex-HDA16217013  
GO:0032991protein-containing complex-IDA11687588  
GO:0035267NuA4 histone acetyltransferase complex-IDA10966108  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
GO:0070062extracellular exosome-HDA11487543  19199708  20458337  21362503  23533145  
GO:0072562blood microparticle-HDA22516433  
GO:0097433dense body-ISS-  
GO:0098793presynapse-TAS18331289  
GO:1990904ribonucleoprotein complex-IDA17289661  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04971Gastric acid secretion
hsa05100Bacterial invasion of epithelial cells
hsa05110Vibrio cholerae infection
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-190828Gap junction traffickingTAS
R-HSA-190873Gap junction degradationTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-196025Formation of annular gap junctionsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisIEA
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationIEA
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-389957Prefoldin mediated transfer of substrate to CCT/TriCIEA
R-HSA-389958Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingIEA
R-HSA-390450Folding of actin by CCT/TriCIEA
R-HSA-390466Chaperonin-mediated protein foldingIEA
R-HSA-391251Protein foldingIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-418990Adherens junctions interactionsIEA
R-HSA-418990Adherens junctions interactionsTAS
R-HSA-421270Cell-cell junction organizationIEA
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1TAS
R-HSA-437239Recycling pathway of L1IEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-445095Interaction between L1 and AnkyrinsTAS
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-446728Cell junction organizationIEA
R-HSA-4839726Chromatin organizationIEA
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-5626467RHO GTPases activate IQGAPsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsTAS
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsIEA
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-5663220RHO GTPases Activate ForminsIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18671841PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)Kriegova EBMC Mol Biol
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res
28111298Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke. (2017 Mar)Szostak JFood Chem Toxicol