Gene: RGS10

6001
-
regulator of G protein signaling 10
protein-coding
10q26.11
Ensembl:ENSG00000148908 MIM:602856 Vega:OTTHUMG00000019150 UniprotKB:O43665
NC_000010.11
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.030e-2 (AD)  5.258e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20345915chr10:121296042RGS101.400e-14Smoking27651444
cg00291478chr10:121301041RGS102.870e-8Alcohol consumption per day27843151
cg00291478chr10:121301041RGS106.690e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSF1R0.917
AIF10.913
TYROBP0.904
LY860.903
LAPTM50.899
GPR340.892
BIN20.891
C30.89
IL180.889
LST10.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.345
GPR148-0.313
TMEM191C-0.295
WNT7A-0.292
YBX2-0.284
SDK2-0.278
HES5-0.277
ZFHX2-0.275
KRTAP5-7-0.273
KREMEN2-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RGS10 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS10 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RGS10 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RGS10 mRNA23630614
C430898AGN 194204AGN 194204 results in increased expression of RGS10 mRNA16339527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS10 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of RGS10 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of RGS10 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGS10 mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RGS10 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGS10 mRNA22228805
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RGS10 mRNA20823114
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of RGS10 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of RGS10 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in increased expression of RGS10 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RGS10 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RGS10 mRNA15003993
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RGS10 mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of RGS10 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RGS10 mRNA27339419
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RGS10 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS10 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of RGS10 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RGS10 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of RGS10 mRNA20106945|2163298
C014347decitabinedecitabine affects the expression of RGS10 mRNA23300844
D003976DiazinonDiazinon results in increased methylation of RGS10 gene22964155
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RGS10 mRNA20823114
D002945CisplatinCisplatin affects the expression of RGS10 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RGS10 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RGS10 mRNA21044322
D002945CisplatinRGS10 protein results in increased susceptibility to Cisplatin21044322
D004041Dietary FatsDietary Fats results in decreased expression of RGS10 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of RGS10 mRNA22609946
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RGS10 mRNA19371625
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of RGS10 mRNA25380136
D004237DiuronDiuron results in increased expression of RGS10 mRNA21551480
C067311docetaxelRGS10 protein results in increased susceptibility to docetaxel21044322
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGS10 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS10 mRNA20938992
C039281furanfuran results in increased expression of RGS10 mRNA27387713
D019833GenisteinGenistein results in increased expression of RGS10 mRNA19371625|2301914
D005839GentamicinsGentamicins results in increased expression of RGS10 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RGS10 mRNA24763279
D017313FenretinideFenretinide results in decreased expression of RGS10 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of RGS10 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RGS10 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RGS10 mRNA27392435
C544151jinfukangjinfukang results in increased expression of RGS10 mRNA27392435
D007854LeadLead results in increased expression of RGS10 mRNA19921347
C045463leflunomideleflunomide results in increased expression of RGS10 mRNA28988120
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RGS10 mRNA20823114
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS10 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RGS10 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of RGS10 promoter"26251327
C008493methylselenic acidmethylselenic acid results in increased expression of RGS10 mRNA12517777
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RGS10 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of RGS10 mRNA25380136
D000073878Palm OilPalm Oil results in decreased expression of RGS10 mRNA18042831
D011441PropylthiouracilPropylthiouracil results in decreased expression of RGS10 mRNA24780913
D011794QuercetinQuercetin results in increased expression of RGS10 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of RGS10 mRNA14699072
D012110ReserpineReserpine results in decreased expression of RGS10 mRNA14505795
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of RGS10 mRNA21427059
C541923sandostatinLARsandostatinLAR results in increased expression of RGS10 mRNA17210224
D013629TamoxifenTamoxifen affects the expression of RGS10 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGS10 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS10 mRNA21570461|2323856
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGS10 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGS10 mRNA15652763
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGS10 mRNA23238561
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RGS10 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of RGS10 mRNA23724009
D014212TretinoinTretinoin results in increased expression of RGS10 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RGS10 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of RGS10 mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RGS10 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RGS10 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RGS10 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of RGS10 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RGS10 mRNA21427059
D014750VincristineRGS10 protein results in increased susceptibility to Vincristine21044322
C029297vinylidene chloridevinylidene chloride results in increased expression of RGS10 mRNA26682919
C111237vorinostatvorinostat results in increased expression of RGS10 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IPI18434541  
GO:0005096GTPase activator activity-IDA11443111  18434541  
GO:0005515protein binding-IPI17353931  
GO ID GO Term Qualifier Evidence PubMed
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-IDA11443111  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IDA18434541  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10791963  11443111  
GO:0005829cytosol-IDA11443111  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043679axon terminus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22056472Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. (2012 Feb)Rivero GNeuropharmacology