Gene: RHD

6007
CD240D|DIIIc|RH|RH30|RHCED|RHDVA(TT)|RHDel|RHPII|RHXIII|Rh4|RhDCw|RhII|RhK562-II|RhPI
Rh blood group D antigen
protein-coding
1p36.11
Ensembl:ENSG00000187010 MIM:111680 Vega:OTTHUMG00000003476 UniprotKB:Q02161
NG_007494.1
PubMed
0   ANCO-SNPs
ND|AD
5   
4.104e-1 (AD)  9.817e-1 (ND)   (Frontal_Cortex)
4.269e-1 (AD)  8.632e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12421513chr1:25599066RHD4.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPIAP100.543
XKR60.539
ZNF4600.532
TMEM2470.526
OR4D10.521
MAK0.518
ZBTB200.516
PSG30.514
ZNF587B0.509
OR2T120.507

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAD2-0.253
CRYGN-0.236
STARD6-0.221
CHST13-0.216
OSTN-0.216
UGT2B17-0.205
CD244-0.204
KRT78-0.199
KRT17-0.198
KRT13-0.198

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05209SYM001Small Molecule-InvestigationalTarget
DB11597Human Rho(D) immune globulinBiotechDrugApproved|InvestigationalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RHD mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RHD mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RHD mRNA21569818
D004958EstradiolEstradiol results in increased expression of RHD mRNA19484750
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RHD mRNA15003993
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of RHD mRNA26033743
D003300CopperCopper deficiency results in increased expression of RHD mRNA26033743
D003471CuprizoneCuprizone results in increased expression of RHD mRNA26577399
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of RHD mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of RHD mRNA26033743
D005419FlavonoidsFlavonoids results in increased expression of RHD mRNA18035473
D005839GentamicinsGentamicins results in decreased expression of RHD mRNA22061828
C017096n-butoxyethanoln-butoxyethanol results in increased expression of RHD mRNA19812364
C028007nickel monoxidenickel monoxide results in decreased expression of RHD mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RHD mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RHD mRNA25729387
D010615PhenacetinPhenacetin results in increased expression of RHD mRNA17082564
C030299phenylhydrazinephenylhydrazine results in increased expression of RHD mRNA17082564
D011441PropylthiouracilPropylthiouracil results in decreased expression of RHD mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RHD mRNA19490992
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RHD mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RHD mRNA25729387
D014212TretinoinTretinoin results in increased expression of RHD mRNA16604517

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008519ammonium transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0072488ammonium transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1438298  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17197601Fetal death. (2007 Jan)Silver RMObstet Gynecol
19222026The effect of Rhesus status on first-trimester pregnancy screening markers free beta human chorionic gonadotropin, pregnancy-associated plasma protein-A and nuchal translucency. (2009 May)Cowans NJPrenat Diagn
27368027A cohort study of relationship between serum calcium levels and cerebral microbleeds (CMBs) in ischemic stroke patients with AF and/or RHD. (2016 Jun)Liu JMedicine (Baltimore)
27920275Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease. (2017 Feb 28)Li NBiosci Rep
23209579Rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in Czech soldiers. (2012)Flegr JPLoS One