Gene: RHO

6010
CSNBAD1|OPN2|RP4
rhodopsin
protein-coding
3q22.1
Ensembl:ENSG00000163914 MIM:180380 Vega:OTTHUMG00000159542 UniprotKB:P08100
NG_009115.1
PubMed
CD|OD|ND|AD
105   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.233e-1 (AD)  7.216e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP26B10.749
TRABD2A0.74
ABCC120.729
NPBWR20.711
PRSS160.707
ADTRP0.707
RASGRP10.706
TYRP10.705
TRPV60.705
ARL4D0.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG12-0.59
PARD3B-0.588
YES1-0.584
PRKD3-0.57
PDLIM5-0.562
REST-0.556
MAML2-0.551
EPS8-0.544
CDC14A-0.544
PELI2-0.538

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01646N-AcetylmethionineSmall Molecule65-82-7ExperimentalTarget
DB017283-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-GlycerolSmall MoleculeExperimentalTarget
DB02482PhosphonothreonineSmall MoleculeExperimentalTarget
DB03152B-2-OctylglucosideSmall MoleculeExperimentalTarget
DB03381HexadecanalSmall Molecule629-80-1ExperimentalTarget
DB03796Palmitic AcidSmall Molecule57-10-3Approved|ExperimentalTarget
DB04079Heptane-1,2,3-TriolSmall MoleculeExperimentalTarget
DB04147Lauryl Dimethylamine-N-OxideSmall MoleculeExperimentalTarget
DB04233(Hydroxyethyloxy)Tri(Ethyloxy)OctaneSmall MoleculeExperimentalTarget
DB04450Heptyl 1-ThiohexopyranosideSmall MoleculeExperimentalTarget
DB04522DexfosfoserineSmall Molecule407-41-0ExperimentalTarget
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of RHO mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RHO mRNA"23146750
C0313909-cis-retinal9-cis-retinal analog results in decreased activity of RHO protein mutant form8120004
D000082AcetaminophenAcetaminophen affects the expression of RHO mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RHO gene27153756
C103303alitretinoin[alitretinoin co-treated with Thyroid Hormones] results in decreased expression of RHO mRNA15270780
C103303alitretinoinalitretinoin results in decreased expression of RHO mRNA15270780
D000638AmiodaroneAmiodarone affects the expression of RHO mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RHO mRNA16483693
D001507BeclomethasoneBeclomethasone results in increased expression of RHO mRNA23656298
C006780bisphenol Abisphenol A results in increased expression of RHO mRNA23146750
C006780bisphenol Abisphenol A results in decreased methylation of RHO promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of RHO mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RHO gene28505145
D002104CadmiumCadmium results in increased expression of RHO mRNA20447699
D002273CarcinogensCarcinogens results in increased expression of RHO mRNA22269147
D002746ChlorpromazineChlorpromazine affects the expression of RHO mRNA25064622
D016572CyclosporineCyclosporine affects the expression of RHO mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RHO mRNA25064622
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of RHO gene16332273
C000591741Firemaster 550Firemaster 550 results in decreased expression of RHO mRNA27957850
D005839GentamicinsGentamicins results in increased expression of RHO protein mutant form18644591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of RHO mRNA15458575
D015122MercaptopurineMercaptopurine results in increased expression of RHO mRNA23358152
D008627Mercuric ChlorideMercuric Chloride results in decreased stability of and affects the activity of RHO protein24911398
D009153MutagensMutagens results in increased expression of RHO mRNA22269147
D019319Okadaic AcidOkadaic Acid results in decreased expression of RHO mRNA25270620
D010269ParaquatParaquat affects the expression of RHO mRNA25064622
D010269ParaquatParaquat results in increased expression of RHO mRNA15458575
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RHO mRNA23228703
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RHO protein23228703
D010936Plant ExtractsPlant Extracts results in decreased expression of RHO mRNA23557933
D012172RetinaldehydeRetinaldehyde analog results in decreased activity of RHO protein mutant form8120004
D012172RetinaldehydeRetinaldehyde binds to RHO protein17109408
D012172RetinaldehydeRetinaldehyde binds to RHO protein15194703
D012172RetinaldehydeZinc affects the reaction [Retinaldehyde binds to RHO protein]15194703
C009167retinylamineretinylamine analog binds to and results in decreased activity of RHO protein9391065
C009167retinylamineretinylamine analog binds to and results in decreased activity of RHO protein mutant form9391065
C009167retinylamineretinylamine analog inhibits the reaction [GNAT1 protein results in increased phosphorylation of RHO protein mutant form]9391065
D012834SilverSilver analog results in decreased expression of RHO mRNA22727896
D012835Silver NitrateSilver Nitrate results in increased expression of RHO mRNA22727896
D013752TetracyclineTetracycline affects the expression of RHO mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of RHO mRNA25064622
D013963Thyroid Hormones[alitretinoin co-treated with Thyroid Hormones] results in decreased expression of RHO mRNA15270780
D013963Thyroid HormonesThyroid Hormones results in increased expression of RHO mRNA15270780
C009495titanium dioxidetitanium dioxide results in increased expression of RHO mRNA23557971
D014212TretinoinTretinoin results in decreased expression of RHO mRNA28689802
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of RHO mRNA29529285
D014415TunicamycinTunicamycin results in increased expression of RHO mRNA15458575
D014635Valproic AcidValproic Acid affects the expression of RHO mRNA25064622
D014635Valproic AcidValproic Acid results in increased methylation of RHO gene29154799
D014635Valproic AcidValproic Acid affects the expression of RHO mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RHO gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of RHO mRNA"22326570
D015032ZincZinc affects the reaction [Retinaldehyde binds to RHO protein]15194703
D015032ZincZinc affects the stability of RHO protein19206210
D015032ZincZinc binds to and affects the folding of RHO protein15194703

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS8107847  
GO:000550211-cis retinal binding-ISS-  
GO:0005515protein binding-IPI12754272  17693260  19934218  
GO:0008020G-protein coupled photoreceptor activity-IBA21873635  
GO:0008020G-protein coupled photoreceptor activity-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0006468protein phosphorylation-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IMP2218504  
GO:0007601visual perception-IEA-  
GO:0007602phototransduction-IBA21873635  
GO:0007603phototransduction, visible light-TAS1418997  
GO:0016038absorption of visible light-ISS-  
GO:0016056rhodopsin mediated signaling pathway-ISS-  
GO:0018298protein-chromophore linkage-IEA-  
GO:0022400regulation of rhodopsin mediated signaling pathway-TAS-  
GO:0045494photoreceptor cell maintenance-IEA-  
GO:0060041retina development in camera-type eye-IEA-  
GO:0071482cellular response to light stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0001750photoreceptor outer segment-IBA21873635  
GO:0001750photoreceptor outer segment-IDA11767049  23704327  
GO:0001917photoreceptor inner segment-IDA11767049  
GO:0005794Golgi apparatus-IDA11767049  
GO:0005886plasma membrane-IDA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8253795  
GO:0005911cell-cell junction-IEA-  
GO:0016021integral component of membrane-ISS-  
GO:0030660Golgi-associated vesicle membrane-TAS-  
GO:0042622photoreceptor outer segment membrane-IDA19934218  
GO:0060170ciliary membrane-TAS-  
GO:0060342photoreceptor inner segment membrane-IDA19934218  
GO:0097381photoreceptor disc membrane-IDA25664179  
GO:0097381photoreceptor disc membrane-TAS-  
KEGG ID KEGG Term
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-2187338Visual phototransductionIEA
R-HSA-2187338Visual phototransductionTAS
R-HSA-2453902The canonical retinoid cycle in rods (twilight vision)TAS
R-HSA-2485179Activation of the phototransduction cascadeIEA
R-HSA-2485179Activation of the phototransduction cascadeTAS
R-HSA-2514856The phototransduction cascadeIEA
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeIEA
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419771OpsinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5617833Cilium AssemblyIEA
R-HSA-5620916VxPx cargo-targeting to ciliumTAS
R-HSA-5620916VxPx cargo-targeting to ciliumIEA
R-HSA-5620920Cargo trafficking to the periciliary membraneTAS
R-HSA-5620920Cargo trafficking to the periciliary membraneIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15217762[Apolipoprotein E and angiotensin-converting enzyme gene polymorphisms as risk factors of coronary disease]. (2004 May-Jun)Bennouar NAnn Biol Clin (Paris)
21817103Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart Study. (2011 Sep)Nguyen ABArterioscler Thromb Vasc Biol
25948783A Healthy Lifestyle Score Is Associated with Cardiometabolic and Neuroendocrine Risk Factors among Puerto Rican Adults. (2015 Jul)Sotos-Prieto MJ Nutr
17616764Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life. (2007 Jul)Hay GAm J Clin Nutr
17657162HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells. (2007)Cirillo PJ Vasc Res
21671890Impact of type 1 diabetes and glycemic control on fetal aneuploidy biochemical markers. (2012 Jan)Madsen HNActa Obstet Gynecol Scand
18485513HbA1c negatively correlates with LCAT activity in type 2 diabetes. (2008 Jul)Nakhjavani MDiabetes Res Clin Pract
22129928Plasma vitamin D levels and risk of metabolic syndrome in Canadians. (2011 Dec 1)Brenner DRClin Invest Med
20443719Hot flushes and biochemical markers for cardiovascular disease: a randomized trial on hormone therapy. (2010 Oct)Tuomikoski PClimacteric
16005461Quantitative genetic analysis of cellular adhesion molecules: the Fels Longitudinal Study. (2006 Mar)Lee MAtherosclerosis
15700195Recent insights into the mechanisms, predisposing factors, and racial differences of coronary vasospasm. (2005 Feb)Miwa KHeart Vessels
27897119Glaucoma: Hot Topics in Pharmacology. (2017)Balendra SICurr Pharm Des
12870724Neutrophilic inflammation in induced sputum of patients with idiopathic pulmonary fibrosis. (2003 Jun)Beeh KMSarcoidosis Vasc Diffuse Lung Dis
20581172A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family. (2010 Oct 15)Polverino FAm J Respir Crit Care Med
29255205Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic asthma: a longitudinal study. (2017 Dec 18)Lodin KNPJ Prim Care Respir Med
24829194Serum human epididymis protein 4 (HE4) as a tumor marker in men with lung cancer. (2014 Nov)Nagy B JrClin Chem Lab Med
7912988Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitics. (1994 Jul)Demoly PAm J Respir Crit Care Med
6730469Lack of association of diagonal earlobe crease with other cardiovascular risk factors. (1984 Feb)Jorde LBWest J Med
26366560RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. (2015)Ojelade SAPLoS One
23301120Smoking in diabetic nephropathy: sparks in the fuel tank? (2012 Dec 15)Chakkarwar VAWorld J Diabetes
10377200Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease. (1999 Jul)Rutgers SRThorax
19504428First-trimester angiopoietin-2: relationships with maternal and placental characteristics. (2010 Jan)Baschat AAAm J Perinatol
25806032Effects of maternal inflammation and exposure to cigarette smoke on birth weight and delivery of preterm babies in a cohort of indigenous Australian women. (2015)Pringle KGFront Immunol
27689196Body Composition Changes in Patients with Chronic Hepatitis C. (2016 Sep)Barbu ECJ Gastrointestin Liver Dis
27123784Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipidemia and Overweight/Obese via Reducing ROCK2 Concentration. (2016 Apr)Hao ZExp Clin Endocrinol Diabetes
11857042Are lifestyle factors good predictors of retinol and vitamin C deficiency in apparently healthy adults? (2002 Feb)Chiplonkar SAEur J Clin Nutr
29614203Changes in the expression of matrix extracellular genes and TGFB family members in rotator cuff tears. (2018 Apr 3)Belangero PSJ Orthop Res
18409824[Urinary 1-naphthol in the general population of Umbria]. (2007 Jul-Sep)Gambelunghe AG Ital Med Lav Ergon
15882283Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. (2005 Jun)Stenvinkel PKidney Int
21744752Human neutrophil peptides sputum levels in symptomatic smokers and COPD patients. (2011 May)Paone GEur Rev Med Pharmacol Sci
18431365Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. (2008 Jul)Romero-Corral ANat Clin Pract Cardiovasc Med
28791728Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study. (2017 Nov)Barrow TMJ Pathol
12818247Homocysteine and hemostatic disorder as a risk factor for myocardial infarction at a young age. (2003 Mar 15)Ogawa MThromb Res
20636139Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells. (2010 Nov)San Miguel SMJ Periodontol
20049135Recent insights into the mechanisms of vasospastic angina. (2009 Dec)Yoo SYKorean Circ J
17182930Activators of plasminogen and the progression of small abdominal aortic aneurysms. (2006 Nov)Lindholt JSAnn N Y Acad Sci
19495998Impact of risk factors for non-fatal acute myocardial infarction. (2009)Oliveira AEur J Epidemiol
28889479Associations of oral fluid MMP-8 with periodontitis in Swiss adult subjects. (2018 Apr)Mauramo MOral Dis
9103851[Carcinoembryonic antigen and neutrophils in healthy smokers]. (1997 Feb)Kashiwabara KNihon Kyobu Shikkan Gakkai Zasshi
25047166Sperm concentration, hyaluronic acid-binding capacity, aneuploidy and persistent histones in testicular cancer. (2014 Sep)Molnar ZHum Reprod
16521916[Antithrombin III activity in the elderly--association with cardiovascular disease risk factors]. (2005)Kostka BPrzegl Lek
26947596Beneficial Effects of Exercise-Based Cardiac Rehabilitation on High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity in Patients with Acute Coronary Syndrome. (2016 Jul 1)Koba SJ Atheroscler Thromb
26910737Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome. (2016 Jul 1)Seravalli VJ Perinat Med
24832863Association of substance dependence phenotypes in the COGA sample. (2015 May)Wetherill LAddict Biol
11602492Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation. (2001 Oct 16)Barua RSCirculation
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer
26010393Correlations among cognitive and behavioural assessments in patients with dementia due to Alzheimer's disease. (2015 Aug)de Oliveira FFClin Neurol Neurosurg
11796179Serum concentrations of soluble adhesion molecules are related to degree of hyperglycemia and insulin resistance in patients with type 2 diabetes mellitus. (2002 Feb)Matsumoto KDiabetes Res Clin Pract
20139919Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers. (2010 Apr)Hidaka THypertens Res
19934338EphA2 in the early pathogenesis and progression of non-small cell lung cancer. (2009 Dec)Brannan JMCancer Prev Res (Phila)
19854383A descriptive cross-sectional study of the prevalence of 25-hydroxyvitamin D deficiency and association with bone markers in a hospitalized population. (2009 Sep)Bang UCNutr Res
25012994Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers. (2014 Sep)Chenoweth MJCancer Epidemiol Biomarkers Prev
21232152Epidemiology, radiology, and genetics of nicotine dependence in COPD. (2011 Jan 13)Kim DKRespir Res
29652762Distribution and performance of cardiovascular risk scores in a mixed population of HIV-infected and community-based HIV-uninfected individuals in Uganda. (2018 Apr 11)Muiru ANJ Acquir Immune Defic Syndr
23077467Prevalence and risk factors of obesity and hypertension among students at a central university in the West Bank. (2012)Tayem YILibyan J Med
23508702The use of digital peripheral artery tonometry to detect endothelial dysfunction in pregnant women who smoke. (2014 Feb)Pearce CFAm J Perinatol
21903056Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment. (2011 Sep 13)Kikuchi YJ Am Coll Cardiol
25380619ROCK1 as a novel prognostic marker in vulvar cancer. (2014 Nov 7)Akagi EMBMC Cancer
23277285Individual predictors of increased serum mesothelin in asbestos-exposed workers. (2013 Mar)Filiberti RMed Oncol
23755138Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes. (2014)Menzaghi CPLoS One
28370244Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients. (2017 Jun)Janssen KMJJ Clin Periodontol
10559510Lipoprotein(a) serum levels in patients affected by chronic obstructive pulmonary disease. (1999 Dec)Basili SAtherosclerosis
28525877Functional network connectivity predicts treatment outcome during treatment of nicotine use disorder. (2017 Jul 30)Wilcox CEPsychiatry Res Neuroimaging
18070151High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality. (2008 Feb)Johansen JSClin Exp Immunol
21536968Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. (2011 Sep)Brody ALArch Gen Psychiatry
25137041Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. (2014)Pastuszak-Lewandoska DPLoS One
28898507Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. (2018 Apr)Koo BKLiver Int
18474878EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. (2008 Jul 1)Kumar BJ Clin Oncol
18230951Decreased cytokine and chemokine mRNA expression in bronchoalveolar lavage in asymptomatic smoking subjects. (2008)Meuronen ARespiration
28911508Relationship of PCSK9 and Urinary Thromboxane Excretion to Cardiovascular Events in Patients With Atrial Fibrillation. (2017 Sep 19)Pastori DJ Am Coll Cardiol
26867220Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy. (2016)Zungsontiporn NPLoS One
29066090Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (2017 Nov)Allen RJLancet Respir Med
28651327Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics. (2017 Sep 1)Quintero-Platt GAlcohol Alcohol
19159685The GGN and CAG repeat polymorphisms in the exon-1 of the androgen receptor gene are, respectively, associated with insulin resistance in men and with dyslipidemia in women. (2009 Feb)Rodriguez-Gonzalez GJ Steroid Biochem Mol Biol
9189237Diseases in the Byzantine world with special emphasis on the nephropathies. (1997)Eftychiadis ACAm J Nephrol
20052659Placental growth factor in the first trimester: relationship with maternal factors and placental Doppler studies. (2010 Mar)Kasdaglis TUltrasound Obstet Gynecol
21617253Pain perception in knees with circumscribed cartilage lesions is associated with intra-articular IGF-1 expression. (2011 Sep)Schmal HAm J Sports Med
16889763Identification of over-expressed proteins in oral squamous cell carcinoma (OSCC) patients by clinical proteomic analysis. (2007 Feb)Lo WYClin Chim Acta
26758944The Mevalonate Pathway and Innate Immune Hyper-Responsiveness in the Pathogenesis of COPD and Lung Cancer: Potential for Chemoprevention. (2017)Young RPCurr Mol Pharmacol
29782855Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells. (2018 May 18)Matera MGEur J Pharmacol
28217371Pathogenic mechanisms of pancreatitis. (2017 Feb 6)Manohar MWorld J Gastrointest Pharmacol Ther
19032815Lupus-associated endothelial dysfunction, disease activity and arteriosclerosis. (2008 Sep-Oct)Valdivielso PClin Exp Rheumatol
24903943The association of smoking with IGRA and TST results in HIV-1-infected subjects. (2014 Jun)Aichelburg MCInt J Tuberc Lung Dis
19631929Serum pentraxin-3 levels at 11 to 14 weeks' gestation: association with maternal and placental characteristics. (2009 Sep)Baschat AAAm J Obstet Gynecol
22093931[Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma]. (2011 Aug 9)Yibulayin WZhonghua Yi Xue Za Zhi
21955465Development and validation of the online social support for smokers scale. (2011 Sep 28)Graham ALJ Med Internet Res
18221090Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases. (2006 Nov)Hu ERecent Pat Cardiovasc Drug Discov
20955285Intima-media thickness of carotid arteries and erectile dysfunction in hemodialysis patients. (2010 Oct)Stolic RVHemodial Int
26510536Undiagnosed airflow limitation is common in patients with coronary artery disease and associated with cardiac stress. (2016 Jan)Ko FWRespirology
23732235CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: a smoking gun? (2014 Feb)Jiang LBiochim Biophys Acta
22717352[Relationship between the plasmatic level of thyrotropin and cardiovascular disease (the Camargo Cohort)]. (2013 Jun 4)Pariente Rodrigo EMed Clin (Barc)
27899881Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction. (2016)Zhang YFront Mol Neurosci
25763815Association of systemic inflammation with epicardial fat and coronary artery calcification. (2015 May)Gauss SInflamm Res
28647827Association Between CD4(+), Viral Load, and Pulmonary Function in HIV. (2017 Oct)Islam MLung
14757688Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study. (2004 Feb 24)Schwedhelm ECirculation
17284169RhoA, encoding a Rho GTPase, is associated with smoking initiation. (2007 Nov)Chen XGenes Brain Behav
25197167Smoking is associated with reduced leptin and neuropeptide Y levels and higher pain experience in patients with fibromyalgia. (2014)Bokarewa MIMediators Inflamm
12853766Erectile physiological and pathophysiological pathways involved in erectile dysfunction. (2003 Aug)Andersson KEJ Urol
25086725FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer. (2014 Nov)Seo ANVirchows Arch
25533722Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis. (2014 Dec 23)Churchman SMArthritis Res Ther
9669624Impact of smoking cessation on salivary function in healthy volunteers. (1998 Jun)Trudgill NJScand J Gastroenterol
19039061Chlamydial LPS and high-sensitivity CRP levels in serum are associated with an elevated body mass index in patients with cardiovascular disease. (2008 Dec)Lajunen TInnate Immun
22479380Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)McKay JAPLoS One
23776362FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. (2011)Young RPAppl Clin Genet
27605566Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure. (2017 Mar)Dekker RLBiol Res Nurs