Gene: RIT2

6014
RIBA|RIN|ROC2
Ras like without CAAX 2
protein-coding
18q12.3
Ensembl:ENSG00000152214 MIM:609592 Vega:OTTHUMG00000132611 UniprotKB:Q99578
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.985e-1 (AD)  7.956e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYT40.937
DYNC1I10.928
INPP5F0.914
CD2000.914
NSF0.913
FBXL20.913
CADPS0.911
TMEM2460.911
MCF20.911
GLRB0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.508
REST-0.501
YES1-0.498
MTRNR2L2-0.49
MTRNR2L8-0.485
FZD10-0.484
AJUBA-0.483
WWTR1-0.477
RAI14-0.476
RNF135-0.475

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RIT2 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RIT2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RIT2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RIT2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RIT2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RIT2 mRNA"25510870
D020106AcrylamideAcrylamide results in increased expression of RIT2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RIT2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RIT2 gene28458013
C015001arsenitearsenite results in decreased methylation of RIT2 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of RIT2 mRNA25181051
D002330CarmustineCarmustine results in decreased expression of RIT2 mRNA15980968
D003300CopperMT1 affects the reaction [Copper results in increased expression of RIT2 mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of RIT2 mRNA]16629173
D003300CopperCopper deficiency results in increased expression of RIT2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of RIT2 mRNA19549813
C014347decitabinedecitabine affects the expression of RIT2 mRNA23300844
D002945CisplatinCisplatin affects the expression of RIT2 mRNA23300844
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RIT2 mRNA"25510870
D011374ProgesteroneProgesterone results in increased expression of RIT2 mRNA22238285
D011794QuercetinQuercetin results in increased expression of RIT2 mRNA15309432
D018038Sodium SeleniteSodium Selenite results in decreased expression of RIT2 mRNA18175754
D014635Valproic AcidValproic Acid results in decreased methylation of RIT2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RIT2 mRNA19101580

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003924GTPase activity-ISS-  
GO:0003924GTPase activity-NAS8824319  
GO:0005515protein binding-IPI21957239  
GO:0005516calmodulin binding-IDA8918462  
GO:0005516calmodulin binding-ISS-  
GO:0005525GTP binding-ISS-  
GO:0030215semaphorin receptor binding-IPI16122393  
GO:0042802identical protein bindingNOTIDA21957239  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascadeNOTISS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007264small GTPase mediated signal transduction-NAS8824319  
GO:0007265Ras protein signal transduction-ISS-  
GO:0007268chemical synaptic transmission-TAS8918462  
GO:0010976positive regulation of neuron projection development-IGI16157584  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0010977negative regulation of neuron projection development-IEA-  
GO:0030100regulation of endocytosis-IMP21957239  
GO:0032489regulation of Cdc42 protein signal transduction-ISS-  
GO:0032507maintenance of protein location in cell-IMP21957239  
GO:0035556intracellular signal transduction-IDA21957239  
GO:0043410positive regulation of MAPK cascade-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0050848regulation of calcium-mediated signaling-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16122393  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IDA16122393  21957239  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS8824319  
GO:0043005neuron projection-IDA21957239  
GO:0044297cell body-ISS-  
GO:0045121membrane raft-IDA21957239  
GO:0097447dendritic tree-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187687Signalling to ERKsIEA
R-HSA-187706Signalling to p38 via RIT and RINIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25889363Personal exposure to PM2.5, genetic variants and DNA damage: a multi-center population-based study in Chinese. (2015 Jun 15)Chu MToxicol Lett