Gene: RLBP1

6017
CRALBP
retinaldehyde binding protein 1
protein-coding
15q26.1
Ensembl:ENSG00000140522 MIM:180090 Vega:OTTHUMG00000172884 UniprotKB:P12271
NG_008116.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.261e-2 (AD)  9.895e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A100.81
PIPOX0.8
GPR37L10.788
SFXN50.783
GRIN2C0.78
PYGM0.774
SLC13A50.765
CDC42EP40.765
SELENBP10.763
ACSS10.76

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF10-0.475
L3MBTL3-0.437
SYNPO2-0.431
GCNT1-0.428
CCDC68-0.424
ATP8B1-0.422
DACH1-0.419
CEP120-0.416
TLL1-0.413
FOXP2-0.41

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00162Vitamin ASmall Molecule68-26-8Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RLBP1 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of RLBP1 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of RLBP1 mRNA26577399
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RLBP1 mRNA28962523
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RLBP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RLBP1 mRNA17942748
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RLBP1 mRNA26752646
D009538NicotineNicotine results in increased expression of RLBP1 mRNA17997037
D012172RetinaldehydeRetinaldehyde binds to RLBP1 protein16968212
D012999SomanSoman results in decreased expression of RLBP1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of RLBP1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RLBP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RLBP1 promoter]19654925
D014212TretinoinTretinoin results in decreased expression of RLBP1 mRNA20530235
D014635Valproic AcidValproic Acid results in increased expression of RLBP1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RLBP1 gene25560391
D014801Vitamin A[Vitamin A co-treated with RLBP1 protein] binds to SLC9A3R1 protein16553463
D014801Vitamin AVitamin A binds to RLBP1 protein16968212

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:000550211-cis retinal binding-IEA-  
GO:0019841retinol binding-IEA-  
GO:1902936phosphatidylinositol bisphosphate binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0006776vitamin A metabolic process-TAS9326942  
GO:0007601visual perception-IEA-  
GO:0050896response to stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
GO:0044297cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-2187335The retinoid cycle in cones (daylight vision)IEA
R-HSA-2187335The retinoid cycle in cones (daylight vision)TAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-2187338Visual phototransductionTAS
R-HSA-2453864Retinoid cycle disease eventsTAS
R-HSA-2453902The canonical retinoid cycle in rods (twilight vision)TAS
R-HSA-2474795Diseases associated with visual transductionTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16462896Integrative strategies to identify candidate genes in rodent models of human alcoholism. (2006 Jan)Treadwell JAGenome