Gene: RLF

6018
ZN-15L|ZNF292L
rearranged L-myc fusion
protein-coding
1p34.2
Ensembl:ENSG00000117000 MIM:180610 Vega:OTTHUMG00000005763 UniprotKB:Q13129
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.448e-1 (AD)  3.075e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12074893chr1:40162447 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNT20.924
TCERG10.901
REV10.897
MED230.895
NUP1530.894
COG30.893
YTHDC20.89
DOPEY10.886
NAA250.885
RCOR30.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.49
OR4F29-0.459
KLRC2-0.309
S100A1-0.281
NKX6-1-0.271
PLA2G5-0.263
HIGD1B-0.26
MTRNR2L10-0.256
PINLYP-0.251
MTRNR2L9-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RLF mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RLF mRNA"21346803
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of RLF mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of RLF mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of RLF mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RLF gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RLF mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of RLF mRNA"23195993
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of RLF mRNA"18687144
C006780bisphenol Abisphenol A affects the methylation of RLF promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of RLF mRNA25181051
C004656chloroacetaldehydechloroacetaldehyde affects the expression of RLF mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RLF mRNA23650126
C059262cidofovircidofovir results in decreased expression of RLF mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of RLF mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased expression of RLF mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of RLF mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of RLF mRNA22077320
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RLF mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RLF mRNA27392435
D002945CisplatinCisplatin results in increased expression of RLF mRNA25596134
D004041Dietary FatsDietary Fats results in decreased expression of RLF mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RLF mRNA21658437
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RLF mRNA22079256
D011345FenofibrateFenofibrate results in increased expression of RLF mRNA25596134
D005557FormaldehydeFormaldehyde results in decreased expression of RLF mRNA20655997
D007069IfosfamideIfosfamide results in increased expression of RLF mRNA25596134
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RLF mRNA27392435
C544151jinfukangjinfukang results in decreased expression of RLF mRNA27392435
D008687MetforminMetformin results in increased expression of RLF mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of RLF mRNA19564919
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of RLF mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of RLF mRNA21664453
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of RLF mRNA"29244179
D009532NickelNickel results in increased expression of RLF mRNA23195993
C022838nickel chloridenickel chloride affects the expression of RLF mRNA22110744
D009538NicotineNicotine results in increased expression of RLF mRNA16949557
D010100OxygenOxygen deficiency results in increased expression of RLF mRNA24236059|2559613
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of RLF mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of RLF mRNA19159669
D010938Plant OilsPlant Oils results in increased expression of RLF mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RLF mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RLF mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of RLF mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of RLF mRNA20631399
C045950propiconazolepropiconazole results in increased expression of RLF mRNA21278054
D011794QuercetinQuercetin results in increased expression of RLF mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of RLF mRNA25596134
D012822Silicon DioxideSilicon Dioxide results in increased expression of RLF mRNA25351596
D012999SomanSoman results in increased expression of RLF mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of RLF mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RLF mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RLF mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RLF mRNA28065790
D014635Valproic AcidValproic Acid results in decreased expression of RLF mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-NAS8545128  
GO:0005515protein binding-IPI10545207  24136289  
GO:0008270zinc ion binding-TAS8545128  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS8545128  
GO:0015074DNA integration-IDA1851085  
GO:0044030regulation of DNA methylation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-ISS8545128  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS8545128  
GO:0051276chromosome organization-IDA1649386  
GO:0051276chromosome organization-NAS8545128  
GO:0097692histone H3-K4 monomethylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC8545128  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal