Gene: AFAP1

60312
AFAP|AFAP-110|AFAP110
actin filament associated protein 1
protein-coding
4p16.1
Ensembl:ENSG00000196526 MIM:608252 Vega:OTTHUMG00000125515 UniprotKB:Q8N556
NC_000004.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.334e-1 (AD)  6.698e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10135894chr4:7862655AFAP1Gene body2.093e-4Alcohol use disorders26763658
cg02871827chr4:7862659AFAP1Gene body4.369e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRE0.836
CASK0.806
CAPN50.801
ASAP10.799
RPS6KA30.799
PRRC2B0.795
PDE8B0.793
GSE10.793
DIAPH10.792
AMOTL10.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.548
OR4F29-0.487
CTNNA3-0.312
FXYD3-0.312
MYOT-0.296
ZFP57-0.29
RHBDL2-0.283
FXYD4-0.282
CLEC4E-0.267
ANXA13-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AFAP1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AFAP1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AFAP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AFAP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AFAP1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AFAP1 mRNA"25510870
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AFAP1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of AFAP1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AFAP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AFAP1 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of AFAP1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AFAP1 mRNA16483693
D001104ArbutinArbutin results in decreased expression of AFAP1 mRNA17103032
D001151ArsenicArsenic affects the methylation of AFAP1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of AFAP1 mRNA15761015
C547126AZM551248AZM551248 results in increased expression of AFAP1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AFAP1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to AFAP1 promoter]19654925
C006780bisphenol Abisphenol A results in increased expression of AFAP1 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of AFAP1 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of AFAP1 mRNA24690739
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AFAP1 mRNA"19167446
D016572CyclosporineCyclosporine results in increased expression of AFAP1 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AFAP1 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of AFAP1 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA15784690
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of AFAP1 mRNA24690739
D005492Folic AcidFolic Acid affects the expression of AFAP1 mRNA17320366
D004397FonofosFonofos results in increased methylation of AFAP1 promoter22847954
D017313FenretinideFenretinide results in decreased expression of AFAP1 mRNA28973697
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AFAP1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of AFAP1 mRNA"26251327
C119536nickel acetatenickel acetate affects the expression of AFAP1 mRNA23828170
D010100OxygenOxygen deficiency results in increased expression of AFAP1 mRNA24205000
D010278ParathionParathion results in increased methylation of AFAP1 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of AFAP1 mRNA22178795
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AFAP1 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AFAP1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AFAP1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of AFAP1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of AFAP1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AFAP1 mRNA22714537
C012568terbufosterbufos results in increased methylation of AFAP1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AFAP1 promoter]19654925
D019284ThapsigarginThapsigargin results in increased expression of AFAP1 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AFAP1 mRNA28065790
D014050TolueneToluene results in increased expression of AFAP1 mRNA22967744
D014212TretinoinTretinoin results in decreased expression of AFAP1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of AFAP1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of AFAP1 mRNA26272509
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of AFAP1 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of AFAP1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFAP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AFAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AFAP1 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of AFAP1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AFAP1 gene25560391
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009966regulation of signal transduction-IEA-  
GO:0051493regulation of cytoskeleton organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA-  
GO:0015629actin cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29544748The prognostic value of high LncRNA AFAP1-AS1 expression in various cancers: A systematic review and meta-analysis containing 21 studies. (2018 Jun)Zhou YClin Chim Acta
26463625The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients. (2015 Oct)Deng JBiomed Pharmacother