Gene info: ID 6035

Gene Symbol	Pearson Correlation Coefficient
PLLP	0.926
MOG	0.905
CNP	0.9
MAG	0.897
PPP1R14A	0.895
NINJ2	0.893
EVI2A	0.891
DBNDD2	0.888
ELOVL1	0.887
TF	0.886

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.425
OR4F5	-0.391
CUX2	-0.351
CNGB1	-0.347
NEUROD1	-0.347
HTR3A	-0.298
HCN4	-0.298
NPBWR1	-0.294
CHRNA2	-0.293
PCDH8	-0.284

DrugBank
CTD

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00128	L-Aspartic Acid	Small Molecule	56-84-8	Approved\|Nutraceutical	Target
DB00536	Guanidine	Small Molecule	113-00-8	Approved	Target
DB01812	Adenosine-3'-5'-Diphosphate	Small Molecule		Experimental	Target
DB01842	3'-Phosphate-Adenosine-5'-Diphosphate	Small Molecule		Experimental	Target
DB01942	Formic Acid	Small Molecule	64-18-6	Approved\|Experimental\|Investigational	Target
DB01961	Cytidine 3'-monophosphate	Small Molecule	84-52-6	Experimental	Target
DB02098	Adenosine-2'-5'-Diphosphate	Small Molecule		Experimental	Target
DB02325	Isopropyl Alcohol	Small Molecule	67-63-0	Approved\|Investigational	Target
DB02363	2'-Monophosphoadenosine-5'-Diphosphate	Small Molecule		Experimental	Target
DB02573	2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate	Small Molecule		Experimental	Target
DB02714	3'-Uridinemonophosphate	Small Molecule	84-53-7	Experimental	Target
DB02805	Uracil arabinose-3'-phosphate	Small Molecule		Experimental	Target
DB02987	Cysteine-S-Acetamide	Small Molecule		Experimental	Target
DB03155	1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione	Small Molecule		Experimental	Target
DB03186	U-Pi-a-Pi	Small Molecule		Experimental	Target
DB03326	deoxycytidylyl-3',5'-guanosine	Small Molecule	52474-59-6	Experimental	Target
DB03447	Uridylyl-2'-5'-Phospho-Adenosine	Small Molecule		Experimental	Target
DB03448	2'-Deoxyuridine 3'-Monophosphate	Small Molecule		Experimental	Target
DB03512	Uridine-2',3'-Vanadate	Small Molecule		Experimental	Target
DB03726	Purine Riboside-5'-Monophosphate	Small Molecule		Experimental	Target
DB03765	2'-cytidylic acid	Small Molecule	85-94-9	Experimental	Target
DB03792	5-Amino-1h-Pyrimidine-2,4-Dione	Small Molecule		Experimental	Target
DB03900	2-Methyl-2-Propanol	Small Molecule		Experimental	Target
DB04272	Citric Acid	Small Molecule	77-92-9	Approved\|Nutraceutical	Target
DB04464	N-Formylmethionine	Small Molecule		Experimental	Target
DB04514	Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester	Small Molecule		Experimental	Target
DB08596	5'-deoxy-5'-piperidin-1-ylthymidine	Small Molecule		Experimental	Target
DB08661	1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of RNASE1 mRNA"	19162173
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNASE1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNASE1 mRNA"	27188386
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of RNASE1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RNASE1 mRNA]	17585979
D000171	Acrolein	Acrolein promotes the reaction [RNASE1 protein binds to RNASE1 protein]	16368895
D000171	Acrolein	Hydralazine inhibits the reaction [Acrolein promotes the reaction [RNASE1 protein binds to RNASE1 protein]]	16368895
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of RNASE1 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of RNASE1 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RNASE1 mRNA	16483693
D001241	Aspirin	Aspirin results in increased expression of RNASE1 mRNA	11906190
D001280	Atrazine	Atrazine results in increased expression of RNASE1 mRNA	22378314
C095105	bexarotene	bexarotene results in increased expression of RNASE1 mRNA	16648578
C006780	bisphenol A	bisphenol A results in decreased expression of RNASE1 mRNA	28079927
C006780	bisphenol A	bisphenol A affects the expression of RNASE1 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of RNASE1 mRNA	26079696
D002220	Carbamazepine	Carbamazepine affects the expression of RNASE1 mRNA	25979313
D002922	Ciguatoxins	Ciguatoxins affects the expression of RNASE1 mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of RNASE1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RNASE1 mRNA]	17585979
D003300	Copper	[Copper binds to epicatechin gallate] which results in decreased activity of RNASE1 protein	16884715
D003300	Copper	[Copper binds to epigallocatechin gallate] which results in decreased activity of RNASE1 protein	16884715
D019327	Copper Sulfate	[Copper Sulfate co-treated with Hydrogen Peroxide] affects the metabolism of RNASE1 protein	11487471
D002117	Calcitriol	Calcitriol results in decreased expression of RNASE1 mRNA	26485663
C062669	epicatechin gallate	[Copper binds to epicatechin gallate] which results in decreased activity of RNASE1 protein	16884715
C062669	epicatechin gallate	epicatechin gallate results in decreased activity of RNASE1 protein	16884715
C045651	epigallocatechin gallate	[Copper binds to epigallocatechin gallate] which results in decreased activity of RNASE1 protein	16884715
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased activity of RNASE1 protein	16884715
D006830	Hydralazine	Hydralazine inhibits the reaction [Acrolein promotes the reaction [RNASE1 protein binds to RNASE1 protein]]	16368895
D006861	Hydrogen Peroxide	[Copper Sulfate co-treated with Hydrogen Peroxide] affects the metabolism of RNASE1 protein	11487471
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RNASE1 mRNA	26752646
C008261	lead acetate	lead acetate results in increased expression of RNASE1 mRNA	20542052
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RNASE1 mRNA	26378955
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of RNASE1 mRNA	20843944
C014055	methyl iodide	methyl iodide results in increased methylation of RNASE1 protein	10981816
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RNASE1 mRNA"	20188158
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of RNASE1 mRNA	15240709
C500085	muraglitazar	muraglitazar results in decreased expression of RNASE1 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of RNASE1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of RNASE1 mRNA"	25620056
C028525	N-phenylmaleimide	N-phenylmaleimide analog binds to RNASE1 protein	23384038
D000069463	Olive Oil	Olive Oil analog affects the expression of RNASE1 mRNA	17349074
C046012	pentanal	pentanal results in increased expression of RNASE1 mRNA	26079696
C046652	phenylarsonous acid	phenylarsonous acid analog binds to RNASE1 protein	23384038
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RNASE1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of RNASE1 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RNASE1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of RNASE1 mRNA	17426115
D011374	Progesterone	Progesterone results in increased expression of RNASE1 mRNA	20631399\|2301818
C004532	quinone	quinone promotes the reaction [RNASE1 protein binds to RNASE1 protein]	22138305
C089730	rosiglitazone	rosiglitazone results in decreased expression of RNASE1 mRNA	21515302
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of RNASE1 mRNA"	21148743
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of RNASE1 mRNA	25895662
D012834	Silver	Silver results in increased expression of RNASE1 mRNA	27131904
C016104	sodium bichromate	sodium bichromate results in decreased expression of RNASE1 mRNA	17685462
C016104	sodium bichromate	sodium bichromate results in decreased expression of RNASE1 mRNA	22561333
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RNASE1 mRNA	26378955
D013467	Sulindac	Sulindac results in decreased expression of RNASE1 mRNA	11906190
C501413	tesaglitazar	tesaglitazar results in decreased expression of RNASE1 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RNASE1 mRNA	26377647
C009495	titanium dioxide	titanium dioxide results in increased expression of RNASE1 mRNA	23409001
D014212	Tretinoin	Tretinoin results in increased expression of RNASE1 mRNA	23830798
D014212	Tretinoin	Tretinoin results in decreased expression of RNASE1 mRNA	16604517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of RNASE1 mRNA	17982090
C057693	troglitazone	troglitazone results in decreased expression of RNASE1 mRNA	21515302
D014635	Valproic Acid	Valproic Acid affects the expression of RNASE1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of RNASE1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of RNASE1 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of RNASE1 gene	29154799

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003676	nucleic acid binding	-	IEA	-
GO:0004519	endonuclease activity	-	IBA	21873635
GO:0004522	ribonuclease A activity	-	IEA	-
GO:0004540	ribonuclease activity	-	IBA	21873635
GO:0004540	ribonuclease activity	-	IDA	9826755
GO:0005515	protein binding	-	IPI	17350650

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0051607	defense response to virus	NOT	IDA	9826755
GO:0090501	RNA phosphodiester bond hydrolysis	-	IDA	9826755
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	-

Gene: RNASE1

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)