Gene: RNASE3

6037
ECP|RAF1|RNS3
ribonuclease A family member 3
protein-coding
14q11.2
Ensembl:ENSG00000169397 MIM:131398 Vega:OTTHUMG00000029604 UniprotKB:P12724
NC_000014.9
PubMed
0   ANCO-SNPs
CD|ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.707e-1 (AD)  7.346e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNASE20.89
SNX200.863
CD300A0.838
ABI30.829
MS4A4A0.828
SERPINA10.827
LRRC250.825
TLR20.824
TLR10.823
FCER1G0.821

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.484
CPLX3-0.47
WNT7A-0.463
ATP2C2-0.448
NEUROD6-0.437
EXTL1-0.421
CHRNA4-0.417
ST6GAL2-0.413
ARSF-0.412
MAGIX-0.41

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01411PranlukastSmall Molecule103177-37-3Approved|InvestigationalTarget
DB02098Adenosine-2'-5'-DiphosphateSmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D000485AllergensAllergens results in increased expression of RNASE3 protein10573242
D000485AllergensBeclomethasone affects the reaction [Allergens results in increased expression of RNASE3 protein]10573242
D000485Allergens[Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]10573242
D001507BeclomethasoneBeclomethasone affects the reaction [Allergens results in increased expression of RNASE3 protein]10573242
D001507BeclomethasoneBeclomethasone results in decreased expression of RNASE3 protein10513351|1216658
D001507Beclomethasone[Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]10573242
C006780bisphenol Abisphenol A results in decreased expression of RNASE3 mRNA25181051
D019819BudesonideBudesonide results in decreased expression of RNASE3 protein15612964
C402665CP 31398CP 31398 results in decreased expression of RNASE3 mRNA15155752
D004391DustDust results in decreased expression of RNASE3 mRNA17805423
D000068759Formoterol FumarateFormoterol Fumarate results in decreased expression of RNASE3 protein1443864
C093875montelukastmontelukast results in decreased expression of RNASE3 protein10588996
D052638Particulate MatterParticulate Matter results in increased expression of RNASE3 protein11027454
D000068299Salmeterol Xinafoate[Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]10573242
D000068299Salmeterol XinafoateSalmeterol Xinafoate results in decreased expression of RNASE3 protein15025036
D014635Valproic AcidValproic Acid results in decreased methylation of RNASE3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of RNASE3 protein11027454
C062735zafirlukastzafirlukast results in decreased expression of RNASE3 protein15612964

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IDA23992292  
GO:0003676nucleic acid binding-IEA-  
GO:0004519endonuclease activity-IBA21873635  
GO:0004540ribonuclease activity-IBA21873635  
GO:0004540ribonuclease activity-TAS2745977  
GO ID GO Term Qualifier Evidence PubMed
GO:0002227innate immune response in mucosa-IDA12860195  
GO:0006401RNA catabolic process-TAS2745977  
GO:0019730antimicrobial humoral response-TAS-  
GO:0019731antibacterial humoral response-IDA12860195  
GO:0043152induction of bacterial agglutination-IDA23992292  
GO:0043312neutrophil degranulation-TAS-  
GO:0045087innate immune response-IDA23992292  
GO:0050829defense response to Gram-negative bacterium-IDA23992292  
GO:0050830defense response to Gram-positive bacterium-IDA12860195  23992292  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA12860195  
GO:0090501RNA phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA12860195  
GO:0035578azurophil granule lumen-TAS-  
KEGG ID KEGG Term
hsa05310Asthma
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal