Gene: BCL6

604
BCL5|BCL6A|LAZ3|ZBTB27|ZNF51
B cell CLL/lymphoma 6
protein-coding
3q27.3
Ensembl:ENSG00000113916 MIM:109565 Vega:OTTHUMG00000156441 UniprotKB:P41182
NG_007149.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.371e-1 (AD)  8.131e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF1A0.838
STAT30.83
RELA0.821
LIMK20.816
SLC39A10.816
TMBIM10.804
PRKX0.796
CNN30.791
CHST30.79
ITPKC0.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.429
EDN3-0.414
OR4F29-0.403
MYCNOS-0.393
PPEF1-0.392
ACY3-0.389
CRH-0.381
SLC7A4-0.378
RERGL-0.377
ABCC12-0.375

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of BCL6 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of BCL6 mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of BCL6 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BCL6 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of BCL6 mRNA"20406850
C0276432-chlorodibenzo-4-dioxin2-chlorodibenzo-4-dioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of BCL6 protein]25543051
C0261142-xylene2-xylene results in increased expression of BCL6 mRNA20359517
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL6 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA19191707
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of BCL6 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL6 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of BCL6 mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of BCL6 mRNA15606129
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA22129741
D020106AcrylamideAcrylamide results in increased expression of BCL6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BCL6 gene27153756
C430898AGN 194204AGN 194204 results in decreased expression of BCL6 mRNA15302862
D000967Antimony Sodium GluconateAntimony Sodium Gluconate results in decreased expression of BCL6 protein27546522
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of BCL6 mRNA25339124
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of BCL6 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of BCL6 mRNA23912714
D001151ArsenicArsenic affects the methylation of BCL6 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of BCL6 mRNA24356939
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of BCL6 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of BCL6 mRNA25929836
D001554BenzeneBenzene results in increased expression of BCL6 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of BCL6 mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BCL6 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BCL6 mRNA20713471
C006780bisphenol Abisphenol A results in decreased expression of BCL6 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of BCL6 gene22576693
C006780bisphenol Abisphenol A affects the methylation of BCL6 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of BCL6 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of BCL6 mRNA20977926
C028031cadmium acetatecadmium acetate results in increased expression of BCL6 mRNA18155341
D000074262Canola OilCanola Oil metabolite results in decreased expression of BCL6 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BCL6 mRNA17484886
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL6 mRNA]16006527
C495817CC-8490CC-8490 results in increased expression of BCL6 mRNA15604281
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL6 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of BCL6 mRNA26272509
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of BCL6 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of BCL6 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of BCL6 mRNA16081524
C018021cobaltous chloridecobaltous chloride results in increased expression of BCL6 mRNA22941251
D019327Copper SulfateCopper Sulfate results in increased expression of BCL6 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of BCL6 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of BCL6 mRNA27523638
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of BCL6 mRNA24356939
D003520CyclophosphamideCyclophosphamide results in decreased expression of BCL6 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of BCL6 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of BCL6 mRNA23300844
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of BCL6 mRNA28659758
C007262deoxynivalenoldeoxynivalenol results in increased expression of BCL6 mRNA22968694
D003907DexamethasoneDexamethasone results in decreased expression of BCL6 mRNA21041162
D003976DiazinonDiazinon affects the expression of BCL6 mRNA22546817
D002945CisplatinCisplatin affects the expression of BCL6 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of BCL6 mRNA20705681
D002945CisplatinCisplatin results in increased expression of BCL6 mRNA21532991
D004008DiclofenacDiclofenac results in decreased expression of BCL6 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of BCL6 mRNA28302478
D004026DieldrinDieldrin affects the expression of BCL6 mRNA22546817
D004041Dietary FatsDietary Fats affects the expression of BCL6 mRNA19680557
D004051Diethylhexyl Phthalate[OVAL protein co-treated with Diethylhexyl Phthalate] affects the expression of BCL6 mRNA25093321
D004051Diethylhexyl Phthalate[OVAL protein co-treated with Diethylhexyl Phthalate] affects the expression of BCL6 protein25093321
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of BCL6 mRNA21041162
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of BCL6 mRNA"23811387
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BCL6 mRNA22079256
C004912ethylbenzeneethylbenzene results in increased expression of BCL6 mRNA20359517
C024565ethylene dichlorideethylene dichloride results in decreased expression of BCL6 mRNA28189721
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of BCL6 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of BCL6 mRNA20655997|2341626
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of BCL6 mRNA20846436
C039281furanfuran results in increased expression of BCL6 mRNA26194646
C039281furanfuran results in increased methylation of BCL6 gene22079235
C056507gemcitabinegemcitabine results in increased expression of BCL6 mRNA17039268
D019833GenisteinGenistein results in decreased expression of BCL6 mRNA26865667
D005839GentamicinsGentamicins results in increased expression of BCL6 mRNA22061828
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]23737761
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]23737761
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]23737761
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]]23737761
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]23737761
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]23737761
C425931GW 501516BCL6 mutant form inhibits the reaction [GW 501516 inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]23737761
C000625835HFPO2 compoundHFPO2 compound results in decreased expression of BCL6 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in decreased expression of BCL6 mRNA27553808
C029424hydrazinehydrazine results in decreased expression of BCL6 mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BCL6 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of BCL6 mRNA26191083
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of BCL6 mRNA"26377693
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL6 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to BCL6 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BCL6 mRNA24332044|2443544
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BCL6 protein24332044|2565644
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BCL6 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of BCL6 mRNA25656449
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of BCL6 protein25656449
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of BCL6 protein]25656449
C410337K 7174K 7174 results in increased expression of BCL6 mRNA24086573
C045463leflunomideleflunomide results in increased expression of BCL6 mRNA28988120
D001556LindaneLindane results in increased expression of BCL6 mRNA24356939
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of BCL6 mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BCL6 mRNA25725100
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of BCL6 protein]25656449
D008070LipopolysaccharidesLipopolysaccharides affects the expression of BCL6 protein20348231
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of BCL6 protein25656449
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BCL6 mRNA19675145
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of BCL6 protein20348231
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of BCL6 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of BCL6 mRNA19564919
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to BCL6 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in increased expression of BCL6 mRNA20713471|2592637
D008752Methylene ChlorideMethylene Chloride results in increased expression of BCL6 mRNA20359517
D008752Methylene ChlorideMethylene Chloride results in increased expression of BCL6 mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BCL6 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of BCL6 mRNA16809437
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BCL6 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BCL6 mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of BCL6 mRNA23811387
C051752nefazodonenefazodone results in increased expression of BCL6 mRNA24136188
C015380neoechinulinneoechinulin results in increased expression of BCL6 mRNA19818335
C022838nickel chloridenickel chloride affects the expression of BCL6 mRNA22546817
C025589ochratoxin Aochratoxin A results in decreased expression of BCL6 mRNA23358140
D009966OrphenadrineOrphenadrine affects the expression of BCL6 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of BCL6 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BCL6 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of BCL6 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of BCL6 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BCL6 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BCL6 mRNA]17655762
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of BCL6 mRNA20705681
D000073878Palm OilPalm Oil affects the expression of BCL6 mRNA19680557
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of BCL6 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of BCL6 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BCL6 mRNA]17655762
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of BCL6 mRNA28659758
D010634PhenobarbitalPhenobarbital results in decreased expression of BCL6 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BCL6 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BCL6 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of BCL6 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of BCL6 mRNA18445702
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of BCL6 mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BCL6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BCL6 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of BCL617510236
D011441PropylthiouracilPropylthiouracil results in decreased expression of BCL6 mRNA24780913
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of BCL6 mRNA28659758
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of BCL6 mRNA16497877
C059514resveratrolresveratrol results in decreased expression of BCL6 protein17088997
C059514resveratrolresveratrol results in increased expression of BCL6 mRNA12002526|1256957
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of BCL6 mRNA19564919
C078903seocalcitolseocalcitol results in increased expression of BCL6 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BCL6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of BCL6 mRNA19073995
D012834SilverSilver results in increased expression of BCL6 mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of BCL6 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of BCL6 mRNA12760830
C017947sodium arsenitesodium arsenite results in increased mutagenesis of BCL6 gene25787150
C016104sodium bichromatesodium bichromate results in increased expression of BCL6 mRNA22155349
C016104sodium bichromatesodium bichromate results in decreased expression of BCL6 mRNA25993096
D053260SootSoot results in decreased expression of BCL6 mRNA22461453
D020058StyreneStyrene results in decreased expression of BCL6 mRNA28951217
C016766sulforafansulforafan results in increased expression of BCL6 mRNA26833863
C013698tallowtallow affects the expression of BCL6 mRNA19680557
D013629TamoxifenTamoxifen results in increased expression of BCL6 mRNA15604281
D013629TamoxifenTamoxifen affects the expression of BCL6 mRNA20937368
D013629TamoxifenTamoxifen results in increased expression of BCL6 mRNA25123088
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of BCL6 mRNA25172293
D013749Tetrachlorodibenzodioxin2-chlorodibenzo-4-dioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of BCL6 protein]25543051
D013749TetrachlorodibenzodioxinAHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of BCL6 protein]25543051
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [BCL6 protein binds to CD80 enhancer]25543051
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCL6 mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased activity of BCL6 protein25543051
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCL6 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCL6 protein27546522
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of BCL6 protein] which results in decreased expression of CD69 protein25543051
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of BCL6 protein] which results in decreased expression of CD80 protein25543051
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCL6 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of BCL6 protein20348231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCL6 mRNA18684927|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCL6 mRNA17035482|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCL6 mRNA22298810
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of BCL6 protein] which results in decreased expression of CD80 protein27546522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL6 mRNA25613284
C402696TMC 120ATMC 120A results in increased expression of BCL6 mRNA19818335
D014050TolueneToluene results in increased expression of BCL6 mRNA20359517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of BCL6 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of BCL6 mRNA20359517
D014241TrichloroethyleneTrichloroethylene results in increased methylation of BCL6 gene27618143
C012589trichostatin Atrichostatin A affects the expression of BCL6 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BCL6 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of BCL6 mRNA29024780
D014415TunicamycinTunicamycin results in increased expression of BCL6 mRNA17127020
D014520UrethaneUrethane results in increased expression of BCL6 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of BCL6 mRNA17292431
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of BCL6 mRNA16330358
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of BCL6 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of BCL6 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of BCL6 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the methylation of BCL6 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of BCL6 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of BCL6 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of BCL6 mRNA20044591
D019287Zinc SulfateZinc Sulfate results in decreased expression of BCL6 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001161intronic transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IBA21873635  
GO:0003682chromatin binding-IDA12097386  
GO:0003700DNA-binding transcription factor activity-IMP15577913  
GO:0005515protein binding-IPI10898795  12590135  16147992  16819511  21390126  22113614  
25416956  27107012  
GO:0031490chromatin DNA binding-IEA-  
GO:0042802identical protein binding-IPI25416956  
GO:0043565sequence-specific DNA binding-IDA15577913  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000060protein import into nucleus, translocation-IGI11821949  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11929873  15577913  
GO:0000902cell morphogenesis-IEA-  
GO:0001953negative regulation of cell-matrix adhesion-IEA-  
GO:0002467germinal center formation-IEA-  
GO:0002634regulation of germinal center formation-NAS7795255  
GO:0002903negative regulation of B cell apoptotic process-NAS15577913  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA15577913  
GO:0007266Rho protein signal transduction-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030036actin cytoskeleton organization-IEA-  
GO:0030183B cell differentiation-IEA-  
GO:0030308negative regulation of cell growth-IDA10490843  
GO:0030890positive regulation of B cell proliferation-IEA-  
GO:0031065positive regulation of histone deacetylation-IEA-  
GO:0032764negative regulation of mast cell cytokine production-IEA-  
GO:0035024negative regulation of Rho protein signal transduction-IEA-  
GO:0042092type 2 immune response-IBA21873635  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043065positive regulation of apoptotic process-IDA10490843  
GO:0043087regulation of GTPase activity-IEA-  
GO:0043380regulation of memory T cell differentiation-IEA-  
GO:0045591positive regulation of regulatory T cell differentiation-IMP22387553  
GO:0045595regulation of cell differentiation-IBA21873635  
GO:0045629negative regulation of T-helper 2 cell differentiation-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IMP15577913  
GO:0045892negative regulation of transcription, DNA-templated-NAS9135990  
GO:0048294negative regulation of isotype switching to IgE isotypes-IEA-  
GO:0048821erythrocyte development-IEA-  
GO:0050727regulation of inflammatory response-IBA21873635  
GO:0050776regulation of immune response-NAS16455075  
GO:0051272positive regulation of cellular component movement-IEA-  
GO:1903464negative regulation of mitotic cell cycle DNA replication-NAS10490843  
GO:2000773negative regulation of cellular senescence-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA7795255  10898795  11929873  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication forkcolocalizes_withIDA10490843  
GO:0005794Golgi apparatus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26927796POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)Zhou HJ Immunol