Gene: BRD2

6046
BRD2-IT1|D6S113E|FSH|FSRG1|NAT|O27.1.1|RING3|RNF3
bromodomain containing 2
protein-coding
6p21.32
Ensembl:ENSG00000204256 MIM:601540 Vega:OTTHUMG00000031241 UniprotKB:P25440
NG_042801.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ILF30.921
EIF4H0.917
HDLBP0.908
APLP20.905
DDX420.899
EIF4G10.899
RNF100.897
PSAP0.897
PITPNA0.893
HNRNPUL20.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.803
OR4F29-0.8
MTRNR2L6-0.267
MTRNR2L10-0.239
MTRNR2L9-0.235
MTRNR2L3-0.208
KLRC2-0.183
KCNG4-0.183
XCL2-0.182
NANOGNB-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BRD2 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of BRD2 mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BRD2 mRNA"21346803
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]"11179685
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"BRD2 mutant form inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]]"26212199
D000082AcetaminophenAcetaminophen results in increased expression of BRD2 mRNA21420995|2649742
D000082AcetaminophenAcetaminophen affects the expression of BRD2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of BRD2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of BRD2 mRNA]17585979
C016601afimoxifeneBRD2 results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BRD2 mRNA19770486
C102351apicidinapicidin affects the localization of BRD2 protein25769527
C547126AZM551248AZM551248 results in increased expression of BRD2 mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of BRD2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BRD2 mRNA19770486|2050435
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BRD2 mRNA"19150397
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]"11179685
D004958EstradiolEstradiol results in increased expression of BRD2 mRNA11179685
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]11179685
C006780bisphenol Abisphenol A results in increased expression of BRD2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of BRD2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BRD2 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BRD2 mRNA25596134
C004656chloroacetaldehydechloroacetaldehyde affects the expression of BRD2 mRNA25596134
C100187chloropicrinchloropicrin results in increased expression of BRD2 mRNA26352163
C059262cidofovircidofovir results in decreased expression of BRD2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of BRD2 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of BRD2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of BRD2 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of BRD2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of BRD2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of BRD2 mRNA25562108|2559613
D003976DiazinonDiazinon results in increased methylation of BRD2 gene22964155
D002945CisplatinCisplatin results in decreased expression of BRD2 mRNA25596134
D002945CisplatinCisplatin results in increased expression of BRD2 mRNA19561079
D002945CisplatinCisplatin results in decreased expression of BRD2 mRNA21151649
D004221DisulfiramDisulfiram results in decreased expression of BRD2 mRNA20530235
D004317DoxorubicinDoxorubicin results in decreased expression of BRD2 mRNA19277126
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of BRD2 mRNA25198161
D011345FenofibrateFenofibrate results in decreased expression of BRD2 mRNA25596134
D005485FlutamideFlutamide results in increased expression of BRD2 mRNA24136188
C039281furanfuran results in increased expression of BRD2 mRNA24183702
D005839GentamicinsGentamicins results in decreased expression of BRD2 mRNA22061828
C014026hexamethylene bisacetamidehexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter]26941288
C492448ICG 001ICG 001 results in increased expression of BRD2 mRNA26191083
D007069IfosfamideIfosfamide results in decreased expression of BRD2 mRNA25596134
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in decreased expression of BRD2 mRNA25989842
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in decreased expression of BRD2 protein25989842
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in increased expression of BRD2 mRNA25989842
C561695(+)-JQ1 compound(+)-JQ1 compound binds to BRD2 protein20871596
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD2 protein binds to BCL2L1 promoter]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BRD2 protein25989842
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BRD2 mRNA23430699|2479639
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to CISH promoter]]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to OSM promoter]]25769527
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to CCNA2 promoter]]"24319289
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to IL6 promoter]]"23420887
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to TNF promoter]]"23420887
C410337K 7174K 7174 results in increased expression of BRD2 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of BRD2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"BRD2 mutant form inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]]"26212199
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL1B mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD2 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to CCNA2 promoter]]"24319289
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to IL6 promoter]]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to TNF promoter]]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to CCNA2 promoter]"24319289
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to IL6 promoter]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD2 protein binds to TNF promoter]"23420887
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of BRD2 mRNA26349765
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of BRD2 protein26349765
D008687MetforminMetformin affects the expression of BRD2 mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of BRD2 mRNA26307267
D008713MethimazoleMethimazole results in decreased expression of BRD2 mRNA22504374
D008727MethotrexateMethotrexate affects the expression of BRD2 mRNA18502557
C002950methylformamidemethylformamide analog results in increased expression of BRD2 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of BRD2 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BRD2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BRD2 mRNA23649840
C029938nickel sulfatenickel sulfate results in decreased expression of BRD2 mRNA18651567
C000605331OTX015OTX015 results in increased expression of BRD2 mRNA27388964
D010100OxygenOxygen deficiency results in decreased expression of BRD2 mRNA25596134
D010100OxygenOxygen deficiency results in increased expression of BRD227292261
D010416PentachlorophenolPentachlorophenol results in increased expression of BRD2 mRNA23892564
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of BRD2 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of BRD2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of BRD2 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of BRD2 mRNA16985257
D010938Plant OilsPlant Oils results in increased expression of BRD2 mRNA23370395
D011441PropylthiouracilPropylthiouracil results in decreased expression of BRD2 mRNA22504374
D011743PyrimidinesPyrimidines results in decreased splicing of BRD2 mRNA25281741
D011794QuercetinQuercetin results in increased expression of BRD2 mRNA21632981
D011799QuinazolinesQuinazolines results in decreased splicing of BRD2 mRNA25281741
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of BRD2 mRNA19244175
D012643SeleniumSelenium results in increased expression of BRD2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of BRD2 mRNA19073995
D012969Sodium FluorideSodium Fluoride results in increased expression of BRD2 mRNA27862939
C004648testosterone enanthatetestosterone enanthate affects the expression of BRD2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA]11179685
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BRD2 mRNA20702594|2157046
D013893ThiramThiram results in decreased expression of BRD2 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BRD2 mRNA28065790
D014204Trenbolone AcetateTrenbolone Acetate results in decreased expression of BRD2 mRNA25198161
C012589trichostatin Atrichostatin A affects the localization of BRD2 protein25769527
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to CISH promoter]]25769527
D014415TunicamycinTunicamycin results in increased expression of BRD2 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of BRD2 mRNA29154799
D014635Valproic AcidValproic Acid affects the localization of BRD2 protein25769527
C025643vinclozolinvinclozolin affects the expression of BRD2 mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of BRD2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of BRD2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of BRD2 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of BRD2 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA18406326  
GO:0005515protein binding-IPI20709061  24229708  
GO:0070577lysine-acetylated histone binding-IDA18406326  
GO ID GO Term Qualifier Evidence PubMed
GO:0006334nucleosome assembly-IMP18406326  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA18406326  
GO:0007283spermatogenesis-TAS9693039  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8951936RUNX3 regulates p14-ARFTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26558777Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. (2015 Nov 11)Sartor GCJ Neurosci