Gene info: ID 60468

Gene: BACH2

GENE ID: 60468

Synonyms: BTBD25

Description: BTB domain and CNC homolog 2

Gene type: protein-coding

Location: 6q15

dbXrefs: Ensembl:ENSG00000112182 MIM:605394 Vega:OTTHUMG00000015216 UniprotKB:Q9BYV9

RefSeq: NC_000006.12

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.382e-1 (AD) 3.997e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs16882302	chr6:89964732 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SIK3	0.777
FNIP1	0.764
CEP97	0.749
SMURF1	0.744
ZNF507	0.741
UNC5C	0.741
ZKSCAN2	0.74
PALM2	0.738
LRRC8D	0.735
BIRC6	0.731

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.401
OR4F29	-0.353
PHEX	-0.31
OR4F16	-0.297
CD8B	-0.289
LINC00189	-0.282
KLRC2	-0.275
XCL2	-0.273
PGF	-0.273
IFNG	-0.271

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BACH2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BACH2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of BACH2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of BACH2 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of BACH2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of BACH2 mRNA	19770486
D000841	Anisomycin	Anisomycin results in increased expression of BACH2 mRNA	24247028
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of BACH2 mRNA	15725085
D001280	Atrazine	Atrazine results in decreased expression of BACH2 mRNA	25929836
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of BACH2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BACH2 mRNA	19770486\|2171566
C006780	bisphenol A	bisphenol A affects the expression of BACH2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of BACH2 mRNA	29097150
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of BACH2 mRNA	24247028
D002104	Cadmium	Cadmium inhibits the reaction [MAFK protein affects the localization of BACH2 protein]	14504288
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of BACH2 protein	14504288
D019256	Cadmium Chloride	U 0126 inhibits the reaction [Cadmium Chloride affects the localization of BACH2 protein]	14504288
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BACH2 gene	20938992
C022990	chromic chloride	chromic chloride results in increased expression of BACH2 mRNA	12128095
D003042	Cocaine	Cocaine affects the expression of BACH2 mRNA	15681117
D016572	Cyclosporine	Cyclosporine results in increased expression of BACH2 mRNA	20106945
C007262	deoxynivalenol	deoxynivalenol results in increased expression of BACH2 mRNA	24247028
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BACH2 mRNA	17361019\|2126653
C042080	diisodecyl phthalate	diisodecyl phthalate results in decreased expression of BACH2 mRNA	25270620
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of BACH2 mRNA	29097150
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BACH2 gene	20938992
D015759	Ionomycin	Ionomycin results in increased expression of BACH2 mRNA	24247028
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BACH2 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound affects the expression of BACH2 mRNA	25656449
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of BACH2 mRNA	21296099
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] promotes the reaction [BACH2 protein binds to PRDM1 intron]	21296099
D008694	Methamphetamine	Methamphetamine results in decreased expression of BACH2 mRNA	26307267
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BACH2 gene	20938992
D008752	Methylene Chloride	Methylene Chloride results in decreased expression of BACH2 mRNA	28392392
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BACH2 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BACH2 mRNA	23179753
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BACH2 mRNA"	20188158
C523799	MRK 003	BACH2 results in decreased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of BACH2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of BACH2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BACH2 mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of BACH2 mRNA	19812364
C558013	NSC 689534	NSC 689534 results in increased expression of BACH2 mRNA	20971185
D010634	Phenobarbital	Phenobarbital results in decreased expression of BACH2 mRNA	19270015\|2309116
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of BACH2 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of BACH2 mRNA	18301758
D011441	Propylthiouracil	Propylthiouracil results in increased expression of BACH2 mRNA	24780913
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of BACH2 mRNA	27862939
D013629	Tamoxifen	Tamoxifen affects the expression of BACH2 mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in decreased expression of BACH2 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BACH2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] promotes the reaction [BACH2 protein binds to PRDM1 intron]	21296099
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BACH2 gene]	20819909\|2176248
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BACH2 intron]	21296099
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BACH2 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BACH2 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BACH2 mRNA	20819909\|2129609
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BACH2 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of BACH2 mRNA	24247028
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of BACH2 mRNA	20133372
C012589	trichostatin A	trichostatin A results in decreased expression of BACH2 mRNA	24935251
C057693	troglitazone	troglitazone results in decreased expression of BACH2 mRNA	28973697
C113580	U 0126	U 0126 inhibits the reaction [Cadmium Chloride affects the localization of BACH2 protein]	14504288
D014520	Urethane	Urethane results in decreased expression of BACH2 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BACH2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BACH2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BACH2 mRNA	26272509
D014635	Valproic Acid	Valproic Acid results in increased expression of BACH2 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in increased methylation of BACH2 gene	29154799
D014638	Vanadates	Vanadates results in increased expression of BACH2 mRNA	22714537
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of BACH2 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0016567	protein ubiquitination	-	IEA	-
GO:0051170	import into nucleus	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-
GO:0005829	cytosol	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25345847	The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease. (2015 Oct)	Kus A	Clin Endocrinol (Oxf)