Gene: RNF4

6047
RES4-26|SLX5|SNURF
ring finger protein 4
protein-coding
4p16.3
Ensembl:ENSG00000063978 MIM:602850 Vega:OTTHUMG00000160516 UniprotKB:P78317
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.193e-1 (AD)  2.293e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27289478chr4:2470262RNF45.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAF20.939
ELAVL10.935
TOP10.934
RPRD1B0.932
PRMT50.93
SURF40.929
TFG0.925
TMEM2480.925
PRPF40.923
BRAP0.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.678
OR4F29-0.618
CTNNA3-0.301
FCRL1-0.3
KLRK1-0.28
KLRB1-0.277
C5orf64-0.271
KLRC2-0.268
TNFRSF13B-0.268
OR6C74-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RNF4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of RNF4 mRNA"20406850
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of RNF4 mRNA19643169
D000082AcetaminophenAcetaminophen affects the expression of RNF4 mRNA17562736
D001151ArsenicRNF4 protein promotes the reaction [Arsenic results in increased degradation of PML protein]18408734
C006632arsenic trioxidearsenic trioxide affects the localization of RNF4 protein20943951
C006632arsenic trioxidearsenic trioxide promotes the reaction [RNF4 protein binds to and results in increased degradation of PML protein modified form]20943951
C006632arsenic trioxidearsenic trioxide promotes the reaction [RNF4 protein binds to SUMO2 protein]20943951
C006632arsenic trioxidearsenic trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein]20943951|2302869
C006632arsenic trioxidearsenic trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein alternative form]23028697
C006632arsenic trioxide[arsenic trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]23028697
C006632arsenic trioxide[[arsenic trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]] which results in increased degradation of PML protein alternative form23028697
C006632arsenic trioxide[arsenic trioxide results in increased sumoylation of PML protein] promotes the reaction [PML protein binds to RNF4 protein]23028697
C006632arsenic trioxide[[arsenic trioxide results in increased sumoylation of PML protein] promotes the reaction [PML protein binds to RNF4 protein]] which results in increased degradation of PML protein23028697
C006632arsenic trioxideRNF4 protein promotes the reaction [arsenic trioxide affects the localization of SUMO2 protein]20943951
C006632arsenic trioxideRNF4 protein promotes the reaction [arsenic trioxide results in increased degradation of PML protein]20943951
C006632arsenic trioxideRNF4 protein promotes the reaction [arsenic trioxide results in increased ubiquitination of PML protein]26060329
D001280AtrazineAtrazine results in decreased expression of RNF4 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RNF4 mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of RNF4 protein14749358
C044887beta-methylcholinebeta-methylcholine affects the expression of RNF4 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RNF4 mRNA25047013
C006780bisphenol Abisphenol A affects the methylation of RNF4 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of RNF4 mRNA26063408
D002104CadmiumCadmium results in increased expression of RNF4 mRNA24376830
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RNF4 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of RNF4 mRNA18353800
D005576Colforsin[Tetradecanoylphorbol Acetate co-treated with Colforsin] results in increased expression of RNF4 mRNA14749358
D003513CycloheximideCycloheximide results in decreased expression of RNF4 protein20943951
D016572CyclosporineCyclosporine results in increased expression of RNF4 mRNA20106945
D003907DexamethasoneRNF4 protein promotes the reaction [Dexamethasone results in increased activity of NR3C1 protein]9710597
D003976DiazinonDiazinon results in increased methylation of RNF4 gene22964155
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RNF4 mRNA14749358
D004054Diethylstilbestrolfulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of RNF4 mRNA]14749358
D004237DiuronDiuron results in increased expression of RNF4 mRNA21551480
D005419FlavonoidsFlavonoids results in decreased expression of RNF4 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of RNF4 mRNA16709241
D005485FlutamideFlutamide results in increased expression of RNF4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RNF4 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of RNF4 mRNA20655997
C069837fullerene C60fullerene C60 results in decreased expression of RNF4 mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of RNF4 mRNA]14749358
D005839GentamicinsGentamicins results in increased expression of RNF4 mRNA22061828
D006918HydroxyureaRNF4 protein results in decreased susceptibility to Hydroxyurea22661230
D006918HydroxyureaRNF4 protein results in decreased susceptibility to Hydroxyurea22661230
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of RNF4 mRNA19376150
D064704LevofloxacinLevofloxacin results in decreased expression of RNF4 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RNF4 gene20938992
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of RNF4 mRNA28349193
C005219methyl cellosolvemethyl cellosolve results in increased expression of RNF4 mRNA19643169
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RNF4 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RNF4 mRNA26924002
C051752nefazodonenefazodone results in increased expression of RNF4 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of RNF4 mRNA19167457
C006253pirinixic acidpirinixic acid results in increased expression of RNF4 mRNA23811191
D011374ProgesteroneRNF4 protein promotes the reaction [Progesterone results in increased activity of PGR protein]9710597
D011748PyrogallolPyrogallol results in increased expression of RNF4 mRNA20362636
C059514resveratrolresveratrol results in decreased expression of RNF4 mRNA12569576
D018038Sodium SeleniteSodium Selenite results in increased expression of RNF4 mRNA18175754
D013739TestosteroneTestosterone results in decreased expression of RNF4 mRNA21669218
D013739TestosteroneRNF4 protein promotes the reaction [Testosterone promotes the reaction [AR protein results in increased expression of PBSN mRNA]]9710597
D013739TestosteroneRNF4 protein promotes the reaction [Testosterone results in increased activity of AR protein]9710597
D013739TestosteroneTestosterone promotes the reaction [RNF4 protein binds to and results in increased activity of AR protein]9710597
D013739TestosteroneTestosterone promotes the reaction [RNF4 protein results in increased expression of PBSN mRNA]9710597
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of RNF4 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF4 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RNF4 mRNA20959002
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Colforsin] results in increased expression of RNF4 mRNA14749358
C009495titanium dioxidetitanium dioxide results in increased expression of RNF4 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RNF4 mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RNF4 mRNA19042947
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RNF4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-TAS9710597  
GO:0003713transcription coactivator activity-NAS15572661  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0005515protein binding-IPI12885770  20212317  
GO:0008134transcription factor binding-IBA21873635  
GO:0008270zinc ion binding-TAS9710597  
GO:0031491nucleosome binding-ISS-  
GO:0032184SUMO polymer binding-ISS-  
GO:0042802identical protein binding-IPI24714598  
GO:0050681androgen receptor binding-NAS15572661  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP18408734  20212317  20943951  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12885770  
GO:0046685response to arsenic-containing substance-IDA20943951  
GO:0051865protein autoubiquitination-ISS-  
GO:0070534protein K63-linked ubiquitination-ISS-  
GO:0070936protein K48-linked ubiquitination-ISS-  
GO:0070979protein K11-linked ubiquitination-ISS-  
GO:0085020protein K6-linked ubiquitination-ISS-  
GO:0090169regulation of spindle assembly-IMP20212317  
GO:0090234regulation of kinetochore assembly-IMP20212317  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12885770  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA12885770  
GO:0016605PML bodyCOLOCALIZES_WITHIBA21873635  
GO:0016605PML bodycolocalizes_withIDA20943951  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-73894DNA RepairTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27113098CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)Wu YYJ Formos Med Assoc