Gene info: ID 6048

Gene: RNF5

GENE ID: 6048

Synonyms: RING5|RMA1

Description: ring finger protein 5

Gene type: protein-coding

Location: 6p21.32

dbXrefs: Ensembl:ENSG00000204308 MIM:602677 Vega:OTTHUMG00000031093 UniprotKB:Q99942

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PARK7	0.945
MRFAP1	0.944
GABARAPL2	0.943
TCEAL4	0.94
TBCB	0.94
YWHAE	0.939
PEBP1	0.937
OAZ2	0.936
EDF1	0.934
UBL5	0.934

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.857
OR4F29	-0.849
MTRNR2L6	-0.28
MTRNR2L9	-0.26
MTRNR2L10	-0.242
TTLL10	-0.235
KCNJ15	-0.22
MTRNR2L3	-0.22
C8orf74	-0.219
TTLL10-AS1	-0.206

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of RNF5 mRNA	15982314
D000082	Acetaminophen	Acetaminophen results in decreased expression of RNF5 mRNA	29067470
D020106	Acrylamide	Acrylamide results in increased expression of RNF5 mRNA	28959563
C103303	alitretinoin	alitretinoin results in decreased expression of RNF5 mRNA	15982314
C006780	bisphenol A	bisphenol A results in increased expression of RNF5 mRNA	25181051
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of RNF5 mRNA	19376846
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RNF5 mRNA	19549813
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of RNF5 mRNA	27281708
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RNF5 mRNA	21266533
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of RNF5 mRNA	27638505
C007738	fluoranthene	[fluoranthene co-treated with Permethrin] results in decreased expression of RNF5 mRNA	22406618
D005839	Gentamicins	Gentamicins results in decreased expression of RNF5 mRNA	22061828
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF5 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RNF5 mRNA	27432991
C005219	methyl cellosolve	methyl cellosolve results in increased expression of RNF5 mRNA	21061450
D008748	Methylcholanthrene	Methylcholanthrene affects the expression of RNF5 mRNA	18804290
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium affects the expression of RNF5 mRNA	25234470
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of RNF5 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of RNF5 mRNA"	25620056
D026023	Permethrin	[fluoranthene co-treated with Permethrin] results in decreased expression of RNF5 mRNA	22406618
D026023	Permethrin	Permethrin results in decreased expression of RNF5 mRNA	22406618
D010795	Phthalic Acids	Phthalic Acids results in increased expression of RNF5 mRNA	21061450
D011374	Progesterone	Progesterone results in increased expression of RNF5 mRNA	18497975
D015474	Isotretinoin	Isotretinoin results in decreased expression of RNF5 mRNA	15982314
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of RNF5 mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in increased expression of RNF5 mRNA	12016162
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RNF5 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RNF5 mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF5 mRNA	25613284
D014212	Tretinoin	Tretinoin results in decreased expression of RNF5 mRNA	15982314
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of RNF5 gene	27618143
D014635	Valproic Acid	Valproic Acid affects the expression of RNF5 mRNA	17963808
D014810	Vitamin E	Vitamin E results in increased expression of RNF5 mRNA	19244175
D015032	Zinc	Zinc deficiency results in increased expression of RNF5 mRNA	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004842	ubiquitin-protein transferase activity	-	IDA	19269966
GO:0005515	protein binding	-	IPI	12861019 14667819 16901789 19269966 19549727 20152160 24019521 25416956 25759021 27107014
GO:0008270	zinc ion binding	-	TAS	9533025
GO:0042802	identical protein binding	-	IPI	25416956
GO:0044390	ubiquitin-like protein conjugating enzyme binding	-	IBA	21873635
GO:0061630	ubiquitin protein ligase activity	-	TAS	24019521

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0009617	response to bacterium	-	IEA	-
GO:0010507	negative regulation of autophagy	-	IEA	-
GO:0030433	ubiquitin-dependent ERAD pathway	-	IGI	24019521
GO:0031648	protein destabilization	-	IEA	-
GO:0036503	ERAD pathway	-	IMP	24019521
GO:0044257	cellular protein catabolic process	-	IMP	19285439
GO:0055085	transmembrane transport	-	TAS	-
GO:0070534	protein K63-linked ubiquitination	-	IDA	19269966
GO:0070936	protein K48-linked ubiquitination	-	IDA	19285439
GO:0071712	ER-associated misfolded protein catabolic process	-	IBA	21873635
GO:0071712	ER-associated misfolded protein catabolic process	-	IMP	19269966
GO:1904380	endoplasmic reticulum mannose trimming	-	TAS	-
GO:2000785	regulation of autophagosome assembly	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0031966	mitochondrial membrane	-	IEA	-
GO:0036513	Derlin-1 retrotranslocation complex	-	IBA	21873635
GO:0036513	Derlin-1 retrotranslocation complex	colocalizes_with	IDA	24019521
GO:0044322	endoplasmic reticulum quality control compartment	-	IEA	-

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382556	ABC-family proteins mediated transport	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5678895	Defective CFTR causes cystic fibrosis	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-901032	ER Quality Control Compartment (ERQC)	TAS
R-HSA-901042	Calnexin/calreticulin cycle	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27909437	Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study. (2016)	Svendsen AJ	Front Immunol