Gene: SLC5A7

60482
CHT|CHT1|CMS20|HMN7A
solute carrier family 5 member 7
protein-coding
2q12.3
Ensembl:ENSG00000115665 MIM:608761 Vega:OTTHUMG00000130959 UniprotKB:Q9GZV3
NG_042267.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.360e-1 (AD)  9.942e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ISL10.981
SLITRK60.961
DDC0.929
LHX80.924
IRX10.916
SLC18A30.871
FAM183A0.851
GHSR0.846
DGKK0.834
EBF20.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.541
SOHLH1-0.473
NEUROD2-0.463
TNNT2-0.446
TESPA1-0.429
EMX1-0.413
NXPH3-0.413
TBR1-0.41
SYTL2-0.405
CABP1-0.396

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalTransporter
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of SLC5A7 mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SLC5A7 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC5A7 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC5A7 mRNA24449571
C015001arsenitearsenite results in increased methylation of SLC5A7 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC5A7 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of SLC5A7 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC5A7 mRNA22079614
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of SLC5A7 mRNA19395590
C026690cerous chloridecerous chloride results in decreased expression of SLC5A7 mRNA23573234
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SLC5A7 mRNA26210949
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SLC5A7 mRNA18812211
D003976DiazinonDiazinon affects the expression of SLC5A7 mRNA17452286
C049863ginsenoside Rdginsenoside Rd results in increased expression of SLC5A7 mRNA24599032
C049864ginsenoside Reginsenoside Re results in increased expression of SLC5A7 mRNA24599032
D006426Hemicholinium 3Nicotine affects the reaction [Hemicholinium 3 binds to SLC5A7 protein]21633116
D006426Hemicholinium 3Hemicholinium 3 binds to SLC5A7 protein21633116
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SLC5A7 protein22381256
D006861Hydrogen Peroxide[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein22381256
D006861Hydrogen Peroxideshogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]22381256
D006861Hydrogen Peroxidestaurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]22381256
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of SLC5A7 protein22381256
D006861Hydrogen Peroxidestaurosporine aglycone inhibits the reaction [[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of SLC5A7 protein]22381256
C008261lead acetatelead acetate affects the expression of SLC5A7 mRNA22641619
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of SLC5A7 mRNA22563483
D009538NicotineNicotine affects the reaction [Hemicholinium 3 binds to SLC5A7 protein]21633116
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC5A7 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC5A7 mRNA27935865
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of SLC5A7 mRNA22563483
D010278ParathionParathion affects the expression of SLC5A7 protein18941570
D010278ParathionParathion results in increased expression of SLC5A7 protein20015457
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC5A7 mRNA27935865
D059808PolyphenolsPolyphenols results in decreased expression of SLC5A7 mRNA16293270
D011374ProgesteroneProgesterone results in increased expression of SLC5A7 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC5A7 mRNA24780913
C040115shogaol[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein22381256
C040115shogaolshogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]22381256
C040115shogaol[shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein22381256
C040115shogaolshogaol results in increased expression of SLC5A7 protein22381256
C040115shogaolstaurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]22381256
D018038Sodium SeleniteSodium Selenite results in decreased expression of SLC5A7 mRNA18175754
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]22381256
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of SLC5A7 protein]22381256
D013849ThimerosalThimerosal results in decreased expression of SLC5A7 mRNA27188386
D014212TretinoinTretinoin results in increased expression of SLC5A7 mRNA21934132
C005460uranyl acetateuranyl acetate results in decreased expression of SLC5A7 mRNA19409444
D014635Valproic AcidValproic Acid affects the expression of SLC5A7 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC5A7 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC5A7 mRNA27935865
D015034Zinc OxideZinc Oxide analog results in decreased expression of SLC5A7 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of SLC5A7 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005307choline:sodium symporter activity-IBA21873635  
GO:0005307choline:sodium symporter activity-IMP12237312  
GO:0015220choline transmembrane transporter activity-IMP11068039  
GO:0015220choline transmembrane transporter activity-TAS-  
GO:0033265choline binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-IEA-  
GO:0007269neurotransmitter secretion-TAS-  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0008292acetylcholine biosynthetic process-IBA21873635  
GO:0008292acetylcholine biosynthetic process-IMP11068039  
GO:0015871choline transport-IBA21873635  
GO:0015871choline transport-IEA-  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA12237312  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IDA11027560  
GO:0030054cell junction-IEA-  
GO:0030424axon-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0031594neuromuscular junction-IDA27569547  
GO:0043204perikaryon-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1643685DiseaseTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619114Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)TAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5658471Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav
23222296Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. (2013 Feb 15)Lau JKCancer Res