Gene: HPSE2

60495
HPA2|HPR2|UFS|UFS1
heparanase 2 (inactive)
protein-coding
10q24.2
Ensembl:ENSG00000172987 MIM:613469 Vega:OTTHUMG00000018880 UniprotKB:Q8WWQ2
NG_023416.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.700e-2 (AD)  3.382e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2487891chr10:99040075 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24591300chr10:100993025HPSE25.100e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PYGM0.772
PSD20.727
PIPOX0.708
MMD20.702
EPHB10.696
KCNJ160.68
SLC7A100.671
SLC13A50.666
KCNJ100.661
ADAMTSL50.661

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD247-0.381
CD163L1-0.38
ARHGEF28-0.375
L3MBTL3-0.373
GCNT1-0.373
MEOX2-0.367
FBLN5-0.366
PLB1-0.359
IGFBP3-0.359
FANCD2-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of HPSE2 mRNA23792671
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HPSE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HPSE2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HPSE2 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HPSE2 gene27153756
C006780bisphenol Abisphenol A affects the expression of HPSE2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HPSE2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HPSE2 gene28505145
D004041Dietary FatsDietary Fats results in decreased expression of HPSE2 mRNA25016146
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of HPSE2 mRNA20846436
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of HPSE2 mRNA27935865
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HPSE2 mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of HPSE2 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of HPSE2 mRNA23557933
D013893ThiramThiram results in decreased expression of HPSE2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of HPSE2 mRNA20530235
D014635Valproic AcidValproic Acid results in increased expression of HPSE2 mRNA24935251

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030305heparanase activityNOTIDA20576607  
GO:0030305heparanase activity-TAS11027606  
GO:0043395heparan sulfate proteoglycan binding-IDA20576607  
GO ID GO Term Qualifier Evidence PubMed
GO:0006027glycosaminoglycan catabolic process-TAS-  
GO:0008150biological_process-ND-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0030198extracellular matrix organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-TAS11027606  
GO:0005886plasma membrane-TAS-  
GO:0031012extracellular matrix-IDA20576607  
KEGG ID KEGG Term
hsa00531Glycosaminoglycan degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-2024096HS-GAG degradationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal