Gene: SCOC

60592
HRIHFB2072|SCOCO|UNC-69
short coiled-coil protein
protein-coding
4q31.1
Ensembl:ENSG00000153130 Vega:OTTHUMG00000133416 UniprotKB:Q9UIL1
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.938e-1 (AD)  3.546e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04761746chr4:141177756SCOC1.600e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2V20.971
SUB10.965
RAB2A0.959
ACP10.958
RAB6A0.957
PJA20.957
LAMTOR30.956
CMAS0.954
NDUFA50.953
PRKAR1A0.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.628
OR4F29-0.605
CSAG1-0.432
EVC2-0.409
MAGEA12-0.395
MTRNR2L10-0.393
MTRNR2L6-0.385
MTRNR2L9-0.377
RUNX3-0.375
TNFRSF10D-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SCOC mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SCOC mRNA16788091
D000082AcetaminophenAcetaminophen affects the expression of SCOC mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SCOC gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SCOC mRNA19770486
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SCOC mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SCOC mRNA22228805
D004958EstradiolEstradiol results in decreased expression of SCOC mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of SCOC mRNA21179406
C006780bisphenol Abisphenol A affects the expression of SCOC mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of SCOC mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of SCOC mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCOC mRNA28628672
C100187chloropicrinchloropicrin results in increased expression of SCOC mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SCOC mRNA28472532
D002994ClofibrateClofibrate results in increased expression of SCOC mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of SCOC mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SCOC mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCOC mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of SCOC mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SCOC mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of SCOC mRNA]19030233
D002117CalcitriolCalcitriol results in increased expression of SCOC mRNA16002434
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SCOC mRNA17942748
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SCOC mRNA22634610
D006046GoldGold results in decreased expression of SCOC mRNA25523186
D017313FenretinideFenretinide results in decreased expression of SCOC mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of SCOC mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCOC mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCOC mRNA28628672
C544151jinfukangjinfukang results in decreased expression of SCOC mRNA27392435
D007854LeadLead affects the expression of SCOC mRNA28903495
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SCOC mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of SCOC mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of SCOC mRNA]22629407
D010416PentachlorophenolPentachlorophenol results in increased expression of SCOC mRNA23892564
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of SCOC mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SCOC mRNA27153767
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of SCOC mRNA]19030233
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of SCOC mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCOC mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SCOC mRNA17942748
D013849ThimerosalThimerosal results in increased expression of SCOC mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SCOC mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of SCOC mRNA25979313
C025643vinclozolinvinclozolin affects the expression of SCOC mRNA19015723
C111237vorinostatvorinostat results in increased expression of SCOC mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of SCOC mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20195357  22354037  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0016239positive regulation of macroautophagy-IDA22354037  
GO:0061635regulation of protein complex stability-IMP22354037  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005768endosomecolocalizes_withIDA22354037  
GO:0005794Golgi apparatus-IDA-  
GO:0005802trans-Golgi networkcolocalizes_withIDA22354037  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27023175Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. (2016 Mar 29)Stringer STransl Psychiatry