Gene: DHX35

60625
C20orf15|DDX35|KAIA0875
DEAH-box helicase 35
protein-coding
20q11.23-q12
Ensembl:ENSG00000101452 Vega:OTTHUMG00000032463 UniprotKB:Q9H5Z1
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.840e-1 (AD)  9.809e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH10.914
VPS33B0.912
CMTR10.912
GLE10.903
TCERG10.903
COG10.899
TRAPPC110.899
C16orf580.899
PPIL20.896
DHX570.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.531
OR4F29-0.483
MTRNR2L6-0.429
MTRNR2L9-0.42
MTRNR2L10-0.375
MTRNR2L8-0.346
KLRC2-0.338
MTRNR2L2-0.331
TMSB15A-0.313
CSAG1-0.312

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of DHX35 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of DHX35 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DHX35 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DHX35 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DHX35 mRNA19770486
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DHX35 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DHX35 mRNA22228805
D002104CadmiumCadmium results in decreased expression of DHX35 mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of DHX35 promoter22457795
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DHX35 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DHX35 mRNA17555576
D017313FenretinideFenretinide results in increased expression of DHX35 mRNA28973697
D007854LeadLead affects the expression of DHX35 mRNA28903495
D008774MethylphenidateMethylphenidate results in decreased expression of DHX35 mRNA22470460
C028007nickel monoxidenickel monoxide results in increased expression of DHX35 mRNA19167457
C410127PCB 180PCB 180 results in decreased expression of DHX35 mRNA23829299
C006253pirinixic acidpirinixic acid results in increased expression of DHX35 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of DHX35 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DHX35 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DHX35 mRNA22079256
D013629TamoxifenTamoxifen affects the expression of DHX35 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHX35 mRNA21570461
C057693troglitazonetroglitazone results in decreased expression of DHX35 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of DHX35 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of DHX35 gene29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of DHX35 mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of DHX35 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0034459ATP-dependent 3'-5' RNA helicase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21546767Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (2011)Murea MAm J Nephrol