Gene: BCL9

607
LGS
B cell CLL/lymphoma 9
protein-coding
1q21.2
Ensembl:ENSG00000116128 MIM:602597 Vega:OTTHUMG00000014031 UniprotKB:O00512
NC_000001.11
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.555e-1 (AD)  1.736e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs716703chr1:147549375 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs12072533chr1:147545754 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAK10.904
RPRD20.891
ZNF1420.89
ARID1A0.889
PRPF80.888
LONP20.887
LRRC410.886
SAP1300.883
CLASP10.882
MTMR10.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.597
OR4F29-0.53
SH2D1A-0.371
CTNNA3-0.359
ANXA13-0.316
KLRC2-0.311
SGMS2-0.303
OR6C74-0.297
C5orf64-0.293
KLRC3-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of BCL9 mRNA28329830
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BCL9 mRNA"19167446
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of BCL9 mRNA"12734338
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of BCL9 mRNA21983209
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BCL9 gene27153756
D001280AtrazineAtrazine results in decreased expression of BCL9 mRNA25929836
D001280AtrazineAtrazine results in increased expression of BCL9 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCL9 mRNA26001963
C006780bisphenol Abisphenol A affects the expression of BCL9 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of BCL9 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of BCL9 mRNA25181051
C026690cerous chloridecerous chloride results in increased expression of BCL9 mRNA23573234
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of BCL9 mRNA17382205
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BCL9 mRNA"19167446
D003907DexamethasoneDexamethasone results in decreased expression of BCL9 mRNA21356098
C000944dicrotophosdicrotophos results in increased expression of BCL9 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of BCL9 mRNA25016146
D004221DisulfiramDisulfiram results in decreased expression of BCL9 mRNA20530235
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of BCL9 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of BCL9 mRNA24793618
D017313FenretinideFenretinide results in decreased expression of BCL9 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BCL9 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of BCL9 mRNA15956246
C051890irinotecanirinotecan results in increased expression of BCL9 mRNA15956246
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BCL9 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BCL9 mRNA"20188158
D008774MethylphenidateMethylphenidate results in decreased expression of BCL9 mRNA22470460
D008777MethyltestosteroneMethyltestosterone results in increased expression of BCL9 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BCL9 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of BCL9 mRNA17382205
D009534NiclosamideNiclosamide results in decreased expression of BCL9 mRNA27338550
C006253pirinixic acidpirinixic acid results in increased expression of BCL9 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BCL9 mRNA17382205
D011794QuercetinQuercetin results in decreased expression of BCL9 mRNA21356098
D018038Sodium SeleniteSodium Selenite results in decreased expression of BCL9 mRNA18175754
D053260SootSoot results in decreased expression of BCL9 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BCL9 mRNA17337447
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BCL9 mRNA25613284
D013893ThiramThiram results in decreased expression of BCL9 mRNA20530235
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of BCL9 mRNA"21356098
D014520UrethaneUrethane results in increased expression of BCL9 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of BCL9 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BCL9 gene25560391
D012256RiboflavinRiboflavin results in decreased expression of BCL9 mRNA21356098

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IEA-  
GO:0005515protein binding-IPI11955446  16630820  17113272  18498752  21399610  
GO:0008013beta-catenin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0014908myotube differentiation involved in skeletal muscle regeneration-IEA-  
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayNOTIMP19328798  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005801cis-Golgi network-IDA23386608  
GO:1990907beta-catenin-TCF complex-IDA28296634  
GO:1990907beta-catenin-TCF complex-IPI11955446  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal