Gene: TNFRSF17

608
BCM|BCMA|CD269|TNFRSF13A
TNF receptor superfamily member 17
protein-coding
16p13.13
Ensembl:ENSG00000048462 MIM:109545 Vega:OTTHUMG00000129826 UniprotKB:Q02223
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.994e-1 (AD)  5.033e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF170.868
OR56A40.865
OR10K10.862
OR9Q20.858
PRDM140.849
TAS2R300.847
OR2A140.841
TMEM2470.829
MTRNR2L50.828
TAS2R410.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HDDC3-0.296
NPM3-0.293
ACRV1-0.28
HENMT1-0.27
CCL27-0.268
CES5A-0.267
KIF9-0.267
C11orf80-0.265
TEX30-0.263
FAM207A-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TNFRSF17 mRNA"23195993
D001151ArsenicArsenic affects the expression of TNFRSF17 protein24675094
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF17 mRNA17530438
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of TNFRSF17 promoter22457795
D003703DemecolcineDemecolcine results in decreased expression of TNFRSF17 mRNA23649840
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of TNFRSF17 mRNA19118595
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TNFRSF17 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of TNFRSF17 mRNA23649840
C039281furanfuran results in increased expression of TNFRSF17 mRNA27387713
D019833GenisteinGenistein results in increased expression of TNFRSF17 mRNA22553218
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF17 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFRSF17 mRNA21949397
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFRSF17 mRNA23649840
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of TNFRSF17 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFRSF17 mRNA"25554681
D009532NickelNickel results in decreased expression of TNFRSF17 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of TNFRSF17 mRNA19167457
D010615PhenacetinPhenacetin results in decreased expression of TNFRSF17 mRNA17698508
C030299phenylhydrazinephenylhydrazine results in decreased expression of TNFRSF17 mRNA17698508
C061133tamibarotenetamibarotene results in increased expression of TNFRSF17 mRNA17229644
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFRSF17 mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF17 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TNFRSF17 mRNA23557971
D014750VincristineVincristine results in decreased expression of TNFRSF17 mRNA23649840
D015032ZincZinc deficiency results in increased expression of TNFRSF17 mRNA22171008
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA16357179
D019345Zinc AcetateZinc Acetate results in decreased expression of TNFRSF17 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0038023signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002260lymphocyte homeostasis-IEA-  
GO:0007165signal transduction-TAS10908663  
GO:0007275multicellular organism development-TAS8165126  
GO:0008283cell proliferation-TAS10908663  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0012505endomembrane system-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04672Intestinal immune network for IgA production
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26614807Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)Martin FHum Exp Toxicol
26735770Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema. (2016 Jun 1)Faner RAm J Respir Crit Care Med