Gene: ROBO1

6091
DUTT1|SAX3
roundabout guidance receptor 1
protein-coding
3p12.3
Ensembl:ENSG00000169855 MIM:602430 Vega:OTTHUMG00000158843 UniprotKB:Q9Y6N7
NG_011729.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.260e-1 (AD)  1.174e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSF10.81
TAOK10.795
ALCAM0.789
FAM172A0.782
FNDC3A0.781
SLC39A60.779
TNKS20.779
WDFY30.779
DNER0.778
UBL30.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.53
NANOGNB-0.236
OR6C74-0.217
FGA-0.208
GRHL2-0.201
AFM-0.194
HMHB1-0.181
CRP-0.176
PAEP-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ROBO1 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of ROBO1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ROBO1 mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ROBO1 mRNA25607892
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ROBO1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ROBO1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ROBO1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ROBO1 mRNA21757418
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ROBO1 mRNA25607892
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of ROBO1 mRNA18585445
D001151ArsenicArsenic affects the methylation of ROBO1 gene25304211
D001151ArsenicArsenic results in decreased expression of ROBO1 mRNA24019935
C006632arsenic trioxidearsenic trioxide results in decreased expression of ROBO1 mRNA15725085
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of ROBO1 mRNA"23917077
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of ROBO1 mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROBO1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROBO1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ROBO1 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROBO1 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ROBO1 mRNA20660070
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ROBO1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of ROBO1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ROBO1 gene28505145
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ROBO1 mRNA25607892
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ROBO1 mRNA27339419
C031180chrysenechrysene results in decreased expression of ROBO1 mRNA26377693
D003300CopperCopper results in decreased expression of ROBO1 mRNA26293553
D019327Copper SulfateCopper Sulfate results in increased expression of ROBO1 mRNA19549813
C014347decitabinedecitabine affects the methylation of ROBO1 promoter17671114
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ROBO1 mRNA]27941970
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ROBO1 mRNA21266533
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
C000944dicrotophosdicrotophos results in increased expression of ROBO1 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of ROBO1 mRNA19680557
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ROBO1 mRNA24535843
D004317DoxorubicinDoxorubicin affects the methylation of ROBO1 gene28962528
C118739entinostatentinostat results in decreased expression of ROBO1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO1 mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ROBO1 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ROBO1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ROBO1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ROBO1 mRNA23649840
D005047EtoposideROBO1 protein affects the susceptibility to Etoposide16217747
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ROBO1 mRNA24796395
C534333JZL 184JZL 184 affects the localization of and affects the expression of ROBO1 protein25030704
C534333JZL 184N-formyl-isoleucine-1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein]25030704
C534333JZL 184pyrazolanthrone inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein]25030704
C534333JZL 184U 0126 inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein]25030704
D007854LeadLead results in increased expression of ROBO1 mRNA19921347
C008261lead acetatelead acetate results in decreased expression of ROBO1 mRNA19737576
C045463leflunomideleflunomide results in increased expression of ROBO1 mRNA28988120
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ROBO1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ROBO1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ROBO1 mRNA23649840
C523799MRK 003ROBO1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ROBO1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ROBO1 mRNA"25620056
C585831N-formyl-isoleucine-1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl esterN-formyl-isoleucine-1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein]25030704
C022838nickel chloridenickel chloride results in increased expression of ROBO1 mRNA17312168
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ROBO1 mRNA25607892
D000073878Palm OilPalm Oil affects the expression of ROBO1 mRNA19680557
D010634PhenobarbitalPhenobarbital affects the expression of ROBO1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ROBO1 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ROBO1 mRNA26272509
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
D011374ProgesteroneProgesterone results in decreased expression of ROBO1 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ROBO1 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of ROBO1 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein]25030704
D011794QuercetinQuercetin results in decreased expression of ROBO1 mRNA21632981
C017947sodium arsenitesodium arsenite results in increased expression of ROBO1 mRNA12760830
C013698tallowtallow affects the expression of ROBO1 mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ROBO1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ROBO1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ROBO1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ROBO1 mRNA17586704
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ROBO1 mRNA26290441
D014212TretinoinTretinoin results in decreased expression of ROBO1 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of ROBO1 mRNA15363585
C012589trichostatin Atrichostatin A results in decreased expression of ROBO1 mRNA24935251
C113580U 0126U 0126 inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein]25030704
D014635Valproic AcidValproic Acid affects the expression of ROBO1 mRNA25979313
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA25607892
C025643vinclozolinvinclozolin results in increased expression of ROBO1 mRNA23034163
D024483Vitamin K 3ROBO1 affects the susceptibility to Vitamin K 322715409
D015034Zinc OxideZinc Oxide analog results in decreased expression of ROBO1 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of ROBO1 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of ROBO1 protein27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12504588  15207848  17848514  26365803  26529257  
GO:0008046axon guidance receptor activity-TAS9458045  
GO:0030275LRR domain binding-IPI17848514  
GO:0042802identical protein binding-IDA12504588  
GO ID GO Term Qualifier Evidence PubMed
GO:0002042cell migration involved in sprouting angiogenesis-IMP19351956  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0003180aortic valve morphogenesis-ISS-  
GO:0003184pulmonary valve morphogenesis-ISS-  
GO:0003272endocardial cushion formation-ISS-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IMP18566128  
GO:0007155cell adhesion-TAS9608531  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IDA12504588  
GO:0007399nervous system development-TAS9608531  
GO:0007411axon guidance-TAS-  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010629negative regulation of gene expression-ISS-  
GO:0016199axon midline choice point recognition-ISS-  
GO:0021836chemorepulsion involved in postnatal olfactory bulb interneuron migration-IDA15207848  
GO:0030336negative regulation of cell migration-IMP26529257  
GO:0033600negative regulation of mammary gland epithelial cell proliferation-IMP18829537  
GO:0035025positive regulation of Rho protein signal transduction-IMP26529257  
GO:0035385Roundabout signaling pathway-IMP18829537  26529257  
GO:0035481positive regulation of Notch signaling pathway involved in heart induction-ISS-  
GO:0035904aorta development-ISS-  
GO:0043406positive regulation of MAP kinase activity-IMP21385766  
GO:0050772positive regulation of axonogenesis-IDA12504588  
GO:0050925negative regulation of negative chemotaxis-IDA11748139  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0070100negative regulation of chemokine-mediated signaling pathway-IMP18829537  
GO:1900748positive regulation of vascular endothelial growth factor signaling pathway-IMP21385766  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA18566128  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9608531  
GO:0009986cell surface-IDA12504588  
GO:0030424axon-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-428540Activation of RAC1IEA
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOIEA
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOTAS
R-HSA-428543Inactivation of CDC42 and RAC1IEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingIEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingTAS
R-HSA-8985586SLIT2:ROBO1 increases RHOA activityTAS
R-HSA-8985801Regulation of cortical dendrite branchingIEA
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9010553Regulation of expression of SLITs and ROBOsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20651036Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. (2010 Dec)Duncan WCMol Hum Reprod