Gene: ROBO2

6092
SAX3
roundabout guidance receptor 2
protein-coding
3p12.3
Ensembl:ENSG00000185008 MIM:602431 Vega:OTTHUMG00000158935 UniprotKB:Q9HCK4
NG_027734.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.022e-1 (AD)  7.597e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB3C0.954
NRXN30.949
PGM2L10.947
FRMPD40.942
PTPRR0.94
NBEA0.939
GDA0.939
EPHA50.937
KRT2220.936
PAK30.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.635
RNF135-0.629
RAB13-0.614
ROM1-0.59
SYDE1-0.589
CHST14-0.588
TGIF1-0.585
AGTRAP-0.58
CMTM3-0.57
REST-0.57

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ROBO2 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ROBO2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ROBO2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ROBO2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ROBO2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ROBO2 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ROBO2 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ROBO2 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ROBO2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROBO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROBO2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ROBO2 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of ROBO2 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ROBO2 mRNA21298039
C041524aluminum sulfatealuminum sulfate results in decreased expression of ROBO2 mRNA15961160
D001280AtrazineAtrazine results in decreased expression of ROBO2 mRNA25929836
C487081belinostatbelinostat results in decreased expression of ROBO2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ROBO2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROBO2 mRNA26001963
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROBO2 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of ROBO2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ROBO2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ROBO2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ROBO2 mRNA22079614
D002220Carbamazepine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of ROBO2 mRNA22701549
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
D002737ChloropreneChloroprene results in decreased expression of ROBO2 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of ROBO2 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ROBO2 mRNA20938992
D003033Coal TarCoal Tar results in decreased expression of ROBO2 mRNA27858113
D003471CuprizoneCuprizone results in decreased expression of ROBO2 mRNA26577399
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNA"18606552
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ROBO2 mRNA25380136
D004147DioxinsDioxins affects the expression of ROBO2 mRNA20463971
C118739entinostatentinostat results in decreased expression of ROBO2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C082360fipronilfipronil results in increased expression of ROBO2 mRNA23962444
D005473Fluoxetine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of ROBO2 mRNA22701549
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ROBO2 mRNA20938992
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNA"18606552
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ROBO2 mRNA17183730
C008261lead acetatelead acetate affects the expression of ROBO2 mRNA21147602
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ROBO2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ROBO2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ROBO2 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ROBO2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ROBO2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ROBO2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ROBO2 mRNA25380136
D009532NickelNickel results in decreased expression of ROBO2 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in increased expression of ROBO2 mRNA24236059
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ROBO2 mRNA"25510870
D010433PentylenetetrazolePentylenetetrazole affects the expression of ROBO2 mRNA21503142
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ROBO2 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ROBO2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of ROBO2 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ROBO2 mRNA21570461
D014212TretinoinTretinoin results in increased expression of ROBO2 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of ROBO2 mRNA24935251
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ROBO2 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROBO2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ROBO2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ROBO2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ROBO2 gene25560391
D000069470Venlafaxine Hydrochloride[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of ROBO2 mRNA22701549
D019287Zinc SulfateZinc Sulfate results in decreased expression of ROBO2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12504588  15207848  
GO:0008046axon guidance receptor activity-ISS-  
GO:0008046axon guidance receptor activity-NAS9458045  
GO:0042802identical protein binding-IDA12504588  
GO ID GO Term Qualifier Evidence PubMed
GO:0001656metanephros development-ISS-  
GO:0001657ureteric bud development-IMP17357069  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0003180aortic valve morphogenesis-ISS-  
GO:0003184pulmonary valve morphogenesis-ISS-  
GO:0003272endocardial cushion formation-ISS-  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IDA12504588  
GO:0007411axon guidance-ISS-  
GO:0007411axon guidance-TAS-  
GO:0007417central nervous system development-NAS9458045  
GO:0007420brain development-IEP10197527  
GO:0016199axon midline choice point recognition-ISS-  
GO:0021510spinal cord development-IEA-  
GO:0021891olfactory bulb interneuron development-ISS-  
GO:0031290retinal ganglion cell axon guidance-ISS-  
GO:0032870cellular response to hormone stimulus-IEP18566128  
GO:0035385Roundabout signaling pathway-IEA-  
GO:0035481positive regulation of Notch signaling pathway involved in heart induction-ISS-  
GO:0035904aorta development-ISS-  
GO:0050772positive regulation of axonogenesis-IDA12504588  
GO:0050925negative regulation of negative chemotaxis-IDA11748139  
GO:0051964negative regulation of synapse assembly-ISS-  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0061364apoptotic process involved in luteolysis-IEP18566128  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA12504588  
GO:0016021integral component of membrane-IEA-  
GO:0030673axolemma-ISS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOTAS
R-HSA-8985801Regulation of cortical dendrite branchingIEA
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9010642ROBO receptors bind AKAP5IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20651036Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. (2010 Dec)Duncan WCMol Hum Reprod