Gene: ROCK1

6093
P160ROCK|ROCK-I
Rho associated coiled-coil containing protein kinase 1
protein-coding
18q11.1
Ensembl:ENSG00000067900 MIM:601702 Vega:OTTHUMG00000131723 UniprotKB:Q13464
NG_042178.2
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.966e-2 (AD)  6.369e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BNIP20.89
SMAD50.869
ITGB10.868
TCF120.866
PTPN210.86
CALD10.855
ATL30.854
REST0.846
STAG20.844
GABPA0.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.543
ADRA1D-0.529
GSG1-0.518
SPEF1-0.504
BHLHA9-0.486
SLC7A4-0.485
HAS1-0.485
PIP5KL1-0.485
FBLN7-0.482
DLK2-0.481

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04707HydroxyfasudilSmall Molecule105628-72-6ExperimentalTarget
DB07876(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINESmall MoleculeExperimentalTarget
DB08162FasudilSmall Molecule103745-39-7InvestigationalTarget
DB08756(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDESmall MoleculeExperimentalTarget
DB13165RipasudilSmall Molecule223645-67-8ApprovedTarget
DB13931NetarsudilSmall Molecule1254032-66-0ApprovedTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of ROCK1 mRNA"20406850
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ROCK1 mRNA20829426
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [TNF protein results in increased phosphorylation of ROCK1 protein]"28743511
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ROCK1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ROCK1 mRNA19770486
D000496AlloxanAlloxan results in increased expression of ROCK1 mRNA12605241
D000496AlloxanAlloxan results in increased expression of ROCK1 protein12605241
D001151ArsenicArsenic affects the methylation of ROCK1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ROCK1 mRNA26238599
C006632arsenic trioxidearsenic trioxide results in increased expression of ROCK1 protein25419056
D017638Asbestos, Crocidolite"ROCK1 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"24760326
D001280AtrazineAtrazine results in increased expression of ROCK1 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of ROCK1 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROCK1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ROCK1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROCK1 mRNA"19150397|2623829
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]20661774
D004958EstradiolEstradiol inhibits the reaction [TNF protein results in increased expression of ROCK1 mRNA]24771768
C006780bisphenol Abisphenol A results in decreased expression of ROCK1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ROCK1 mRNA26314263
C013418bromfenacoumbromfenacoum results in increased expression of ROCK1 protein28903499
C022777bufalinbufalin results in decreased expression of ROCK1 protein23949904
D002101Cacodylic AcidCacodylic Acid results in decreased expression of ROCK1 mRNA17720352
D002104CadmiumCadmium results in decreased expression of ROCK1 mRNA18956198
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ROCK1 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ROCK1 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of ROCK1 mRNA24752500
D002737ChloropreneChloroprene results in increased expression of ROCK1 mRNA23125180
D002857ChromiumChromium results in increased expression of ROCK1 mRNA17692352
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of ROCK1 mRNA26314263
D016572CyclosporineCyclosporine results in decreased expression of ROCK1 mRNA19770486
D003630DaunorubicinDaunorubicin affects the expression of ROCK1 mRNA20037814
D003630Daunorubicinfasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]20037814
C014347decitabinedecitabine results in decreased expression of ROCK1 mRNA27915011
C107676deguelindeguelin results in decreased expression of ROCK1 protein25322282|2688482
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ROCK1 mRNA]27941970
D004008DiclofenacDiclofenac affects the expression of ROCK1 mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of ROCK1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of ROCK1 mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of ROCK1 mRNA]22010203
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA17602206
D004642EmodinEmodin results in decreased expression of ROCK1 mRNA16045814
D004726EndosulfanEndosulfan results in increased expression of and affects the localization of ROCK1 protein22677888
D004967EstrogensEstrogens results in decreased expression of ROCK1 mRNA20970835
D000431EthanolEthanol results in decreased expression of ROCK1 mRNA29018328
C049347fasudilfasudil results in decreased expression of ROCK1 mRNA26172442
C049347fasudilfasudil results in decreased expression of ROCK1 protein26172442
C049347fasudilfasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]20037814
C049347fasudilfasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]23376009
C049347fasudilfasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]22429817
D005947Glucosenotoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]25305180
D005947Glucose[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein25305180
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ROCK1 mRNA22634610
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of ROCK1 mRNA22634610
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of ROCK1 mRNA24680724
D012701SerotoninROCK1 protein affects the susceptibility to Serotonin14690016
D006820Hyaluronic AcidHyaluronic Acid results in increased phosphorylation of ROCK1 protein16864594
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of ROCK1 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ROCK1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of ROCK1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of ROCK1 mRNA15618438
C410337K 7174K 7174 results in increased expression of ROCK1 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of ROCK1 mRNA22609695
C108255levormeloxifenelevormeloxifene results in decreased expression of ROCK1 mRNA20970835
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ROCK1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ROCK1 mRNA21645290
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ROCK1 mRNA26378955
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA22563483
D008731MethoxychlorMethoxychlor affects the expression of ROCK1 mRNA20829426
C030957methylmercury IImethylmercury II results in increased expression of ROCK1 mRNA26314263
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ROCK1 mRNA"26251327
D037742Nanotubes, Carbon"ROCK1 protein promotes the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]"24760326
C025256nonylphenolnonylphenol results in increased expression of ROCK1 mRNA22982499
C072936notoginsenoside R1notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]25305180
C025589ochratoxin Aochratoxin A metabolite results in increased expression of ROCK1 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of ROCK1 mRNA26314263
D010100Oxygennotoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]25305180
D010100Oxygen[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein25305180
D017239PaclitaxelPaclitaxel results in increased expression of ROCK1 mRNA15000894
C019248pamidronatepamidronate results in decreased expression of ROCK1 protein16298452
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA22563483
D010269ParaquatParaquat results in increased expression of ROCK1 mRNA22563483
D052638Particulate MatterParticulate Matter results in increased expression of ROCK1 mRNA18599801
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ROCK1 mRNA27153767
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of ROCK1 mRNA17616710
D010634PhenobarbitalPhenobarbital results in decreased expression of ROCK1 mRNA19363144|2309116
D010936Plant ExtractsPlant Extracts results in decreased expression of ROCK1 protein23955962
D010936Plant ExtractsPlant Extracts results in increased expression of ROCK1 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of ROCK1 mRNA19363144|2127805
D011441PropylthiouracilPropylthiouracil results in increased expression of ROCK1 mRNA24780913
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of ROCK1 mRNA"21152443
C428725pyridabenpyridaben results in increased expression of ROCK1 mRNA22563483
D011794QuercetinQuercetin results in increased expression of ROCK1 protein15221776|2364574
C012526quercitrinquercitrin affects the expression of ROCK1 mRNA25193878
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of ROCK1 mRNA20970835
C059514resveratrolresveratrol results in decreased expression of ROCK1 mRNA18089832
C059514resveratrolresveratrol results in decreased expression of ROCK1 protein18089832
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ROCK1 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of ROCK1 mRNA21795629
C025451sodium bisulfidesodium bisulfide results in increased activity of ROCK1 protein23479079
D018038Sodium SeleniteSodium Selenite results in increased expression of ROCK1 mRNA18175754
C471405sorafenibsorafenib results in decreased expression of ROCK1 mRNA19338580
C471405sorafenibsorafenib results in decreased expression of ROCK1 protein19338580
C471405sorafenibsorafenib results in increased expression of ROCK1 protein19338580
D013311Streptozocinfasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]23376009
D013311Streptozocinfasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]22429817
D013311StreptozocinStreptozocin results in increased activity of ROCK1 protein23376009
D013311StreptozocinStreptozocin results in increased expression of ROCK1 mRNA22429817
D010042Ouabainbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]20661774
D010042OuabainOuabain results in increased cleavage of ROCK1 protein20661774
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ROCK1 mRNA26378955
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of ROCK1 mRNA]22010203
D013739TestosteroneTestosterone affects the expression of ROCK1 mRNA22028410
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ROCK1 mRNA18691609|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ROCK1 mRNA22298810
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ROCK1 protein24760326
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ROCK1 mRNA25613284
C402769tipifarnibtipifarnib results in increased expression of ROCK1 mRNA16403772
C011559tributyltintributyltin results in increased expression of ROCK1 mRNA26314263
C001899triptolidetriptolide results in decreased expression of ROCK1 mRNA26420756
C001899triptolidetriptolide results in decreased expression of ROCK1 mRNA27554044
C057693troglitazonetroglitazone results in increased expression of ROCK1 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of ROCK1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of ROCK1 gene29154799
D002762CholecalciferolCholecalciferol results in increased expression of ROCK1 mRNA17170073
C108830Y 27632Y 27632 results in decreased activity of ROCK1 protein10686302
C108830Y 27632[Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein16675616
C108830Y 27632ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]14615541
C108830Y 27632Y 27632 results in decreased activity of ROCK1 protein14615541|1978275

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS8798490  10436159  
GO:0004674protein serine/threonine kinase activity-IDA10652353  11018042  18573880  18694941  19036714  
GO:0004674protein serine/threonine kinase activity-NAS27853422  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI10652353  14660612  17853893  20230755  21281639  22085929  
25416956  25448675  27853422  
GO:0005524ATP binding-IEA-  
GO:0017049GTP-Rho binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003383apical constriction-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006939smooth muscle contraction-TAS12778124  
GO:0007159leukocyte cell-cell adhesion-IDA12082081  
GO:0007165signal transduction-TAS10436159  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IMP25816133  
GO:0007266Rho protein signal transduction-IGI27160703  
GO:0010506regulation of autophagy-TAS27853422  
GO:0010508positive regulation of autophagy-IGI27853422  
GO:0010613positive regulation of cardiac muscle hypertrophy-IMP28679962  
GO:0010628positive regulation of gene expression-IMP27853422  28679962  
GO:0010628positive regulation of gene expression-ISS-  
GO:0016525negative regulation of angiogenesis-IMP19181962  
GO:0022614membrane to membrane docking-IDA12082081  
GO:0030036actin cytoskeleton organization-TAS10436159  
GO:0030155regulation of cell adhesion-TAS12778124  
GO:0030866cortical actin cytoskeleton organization-IGI25816133  
GO:0030866cortical actin cytoskeleton organization-IMP25816133  
GO:0031175neuron projection development-IGI27160703  
GO:0032060bleb assembly-IEA-  
GO:0032091negative regulation of protein binding-IDA18573880  
GO:0032956regulation of actin cytoskeleton organization-IDA25911094  
GO:0032956regulation of actin cytoskeleton organization-TAS12778124  
GO:0035509negative regulation of myosin-light-chain-phosphatase activity-IGI25816133  
GO:0035509negative regulation of myosin-light-chain-phosphatase activity-IMP25816133  
GO:0043312neutrophil degranulation-TAS-  
GO:0043410positive regulation of MAPK cascade-IMP28679962  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045616regulation of keratinocyte differentiation-IMP19997641  
GO:0045664regulation of neuron differentiation-IGI27160703  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0050900leukocyte migration-IDA12082081  
GO:0050901leukocyte tethering or rolling-IDA12082081  
GO:0051045negative regulation of membrane protein ectodomain proteolysis-TAS27853422  
GO:0051451myoblast migration-ISS-  
GO:0051492regulation of stress fiber assembly-TAS12778124  
GO:0051893regulation of focal adhesion assembly-TAS12778124  
GO:0051894positive regulation of focal adhesion assembly-ISS-  
GO:0070168negative regulation of biomineral tissue development-ISS-  
GO:0071559response to transforming growth factor beta-ISS-  
GO:0072659protein localization to plasma membrane-IGI25816133  
GO:0072659protein localization to plasma membrane-IMP25816133  
GO:0110061regulation of angiotensin-activated signaling pathway-IMP28679962  
GO:0140058neuron projection arborization-IGI27160703  
GO:1900223positive regulation of amyloid-beta clearance-IGI27853422  
GO:1900242regulation of synaptic vesicle endocytosis-IGI27160703  
GO:1902003regulation of amyloid-beta formation-TAS27853422  
GO:1902430negative regulation of amyloid-beta formation-IMP24305806  27853422  
GO:1902992negative regulation of amyloid precursor protein catabolic process-IMP24305806  27853422  
GO:1903140regulation of establishment of endothelial barrier-IGI25816133  
GO:1903140regulation of establishment of endothelial barrier-IMP25816133  
GO:1903347negative regulation of bicellular tight junction assembly-IGI25816133  
GO:1905205positive regulation of connective tissue replacement-IMP28679962  
GO:1990776response to angiotensin-ISS-  
GO:2000114regulation of establishment of cell polarity-TAS20803696  
GO:2000145regulation of cell motility-TAS12778124  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0001726ruffle-ISS-  
GO:0005576extracellular region-TAS-  
GO:0005814centriole-IEA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0010494cytoplasmic stress granule-ISS-  
GO:0030027lamellipodium-ISS-  
GO:0032059bleb-IEA-  
GO:0034774secretory granule lumen-TAS-  
GO:0106003amyloid-beta complexcolocalizes_withIDA27853422  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-400685Sema4D in semaphorin signalingTAS
R-HSA-400685Sema4D in semaphorin signalingIEA
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5627117RHO GTPases Activate ROCKsTAS
R-HSA-5627117RHO GTPases Activate ROCKsIEA
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-75153Apoptotic execution phaseTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25380619ROCK1 as a novel prognostic marker in vulvar cancer. (2014 Nov 7)Akagi EMBMC Cancer
20139919Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers. (2010 Apr)Hidaka THypertens Res