Gene info: ID 6093

Gene: ROCK1

GENE ID: 6093

Synonyms: P160ROCK|ROCK-I

Description: Rho associated coiled-coil containing protein kinase 1

Gene type: protein-coding

Location: 18q11.1

dbXrefs: Ensembl:ENSG00000067900 MIM:601702 Vega:OTTHUMG00000131723 UniprotKB:Q13464

RefSeq: NG_042178.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.966e-2 (AD) 6.369e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BNIP2	0.89
SMAD5	0.869
ITGB1	0.868
TCF12	0.866
PTPN21	0.86
CALD1	0.855
ATL3	0.854
REST	0.846
STAG2	0.844
GABPA	0.841

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.543
ADRA1D	-0.529
GSG1	-0.518
SPEF1	-0.504
BHLHA9	-0.486
SLC7A4	-0.485
HAS1	-0.485
PIP5KL1	-0.485
FBLN7	-0.482
DLK2	-0.481

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04707	Hydroxyfasudil	Small Molecule	105628-72-6	Experimental	Target
DB07876	(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE	Small Molecule		Experimental	Target
DB08162	Fasudil	Small Molecule	103745-39-7	Investigational	Target
DB08756	(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE	Small Molecule		Experimental	Target
DB13165	Ripasudil	Small Molecule	223645-67-8	Approved	Target
DB13931	Netarsudil	Small Molecule	1254032-66-0	Approved	Target

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of ROCK1 mRNA"	20406850
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of ROCK1 mRNA	20829426
C489251	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [TNF protein results in increased phosphorylation of ROCK1 protein]"	28743511
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ROCK1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ROCK1 mRNA	19770486
D000496	Alloxan	Alloxan results in increased expression of ROCK1 mRNA	12605241
D000496	Alloxan	Alloxan results in increased expression of ROCK1 protein	12605241
D001151	Arsenic	Arsenic affects the methylation of ROCK1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ROCK1 mRNA	26238599
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ROCK1 protein	25419056
D017638	Asbestos, Crocidolite	"ROCK1 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"	24760326
D001280	Atrazine	Atrazine results in increased expression of ROCK1 mRNA	22982499
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of ROCK1 mRNA	26314263
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ROCK1 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ROCK1 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROCK1 mRNA"	19150397\|2623829
C110772	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]	20661774
D004958	Estradiol	Estradiol inhibits the reaction [TNF protein results in increased expression of ROCK1 mRNA]	24771768
C006780	bisphenol A	bisphenol A results in decreased expression of ROCK1 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of ROCK1 mRNA	26314263
C013418	bromfenacoum	bromfenacoum results in increased expression of ROCK1 protein	28903499
C022777	bufalin	bufalin results in decreased expression of ROCK1 protein	23949904
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of ROCK1 mRNA	17720352
D002104	Cadmium	Cadmium results in decreased expression of ROCK1 mRNA	18956198
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ROCK1 mRNA	24982889
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of ROCK1 promoter	22457795
D002220	Carbamazepine	Carbamazepine affects the expression of ROCK1 mRNA	24752500
D002737	Chloroprene	Chloroprene results in increased expression of ROCK1 mRNA	23125180
D002857	Chromium	Chromium results in increased expression of ROCK1 mRNA	17692352
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ROCK1 mRNA	26314263
D016572	Cyclosporine	Cyclosporine results in decreased expression of ROCK1 mRNA	19770486
D003630	Daunorubicin	Daunorubicin affects the expression of ROCK1 mRNA	20037814
D003630	Daunorubicin	fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]	20037814
C014347	decitabine	decitabine results in decreased expression of ROCK1 mRNA	27915011
C107676	deguelin	deguelin results in decreased expression of ROCK1 protein	25322282\|2688482
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ROCK1 mRNA]	27941970
D004008	Diclofenac	Diclofenac affects the expression of ROCK1 mRNA	24752500
C000944	dicrotophos	dicrotophos results in decreased expression of ROCK1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of ROCK1 mRNA	22010203
D004041	Dietary Fats	Testosterone inhibits the reaction [Dietary Fats results in increased expression of ROCK1 mRNA]	22010203
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNA	17602206
D004642	Emodin	Emodin results in decreased expression of ROCK1 mRNA	16045814
D004726	Endosulfan	Endosulfan results in increased expression of and affects the localization of ROCK1 protein	22677888
D004967	Estrogens	Estrogens results in decreased expression of ROCK1 mRNA	20970835
D000431	Ethanol	Ethanol results in decreased expression of ROCK1 mRNA	29018328
C049347	fasudil	fasudil results in decreased expression of ROCK1 mRNA	26172442
C049347	fasudil	fasudil results in decreased expression of ROCK1 protein	26172442
C049347	fasudil	fasudil affects the reaction [Daunorubicin affects the expression of ROCK1 mRNA]	20037814
C049347	fasudil	fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]	23376009
C049347	fasudil	fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]	22429817
D005947	Glucose	notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]	25305180
D005947	Glucose	[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein	25305180
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of ROCK1 mRNA	22634610
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of ROCK1 mRNA	22634610
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of ROCK1 mRNA	24680724
D012701	Serotonin	ROCK1 protein affects the susceptibility to Serotonin	14690016
D006820	Hyaluronic Acid	Hyaluronic Acid results in increased phosphorylation of ROCK1 protein	16864594
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of ROCK1 mRNA	19376150
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ROCK1 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of ROCK1 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of ROCK1 mRNA	15618438
C410337	K 7174	K 7174 results in increased expression of ROCK1 mRNA	24086573
C008261	lead acetate	lead acetate results in decreased expression of ROCK1 mRNA	22609695
C108255	levormeloxifene	levormeloxifene results in decreased expression of ROCK1 mRNA	20970835
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of ROCK1 mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of ROCK1 mRNA	21645290
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ROCK1 mRNA	26378955
D008344	Maneb	[Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA	22563483
D008731	Methoxychlor	Methoxychlor affects the expression of ROCK1 mRNA	20829426
C030957	methylmercury II	methylmercury II results in increased expression of ROCK1 mRNA	26314263
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ROCK1 mRNA"	26251327
D037742	Nanotubes, Carbon	"ROCK1 protein promotes the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]"	24760326
C025256	nonylphenol	nonylphenol results in increased expression of ROCK1 mRNA	22982499
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]	25305180
C025589	ochratoxin A	ochratoxin A metabolite results in increased expression of ROCK1 mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in increased expression of ROCK1 mRNA	26314263
D010100	Oxygen	notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]	25305180
D010100	Oxygen	[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein	25305180
D017239	Paclitaxel	Paclitaxel results in increased expression of ROCK1 mRNA	15000894
C019248	pamidronate	pamidronate results in decreased expression of ROCK1 protein	16298452
D010269	Paraquat	[Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA	22563483
D010269	Paraquat	Paraquat results in increased expression of ROCK1 mRNA	22563483
D052638	Particulate Matter	Particulate Matter results in increased expression of ROCK1 mRNA	18599801
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ROCK1 mRNA	27153767
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of ROCK1 mRNA	17616710
D010634	Phenobarbital	Phenobarbital results in decreased expression of ROCK1 mRNA	19363144\|2309116
D010936	Plant Extracts	Plant Extracts results in decreased expression of ROCK1 protein	23955962
D010936	Plant Extracts	Plant Extracts results in increased expression of ROCK1 mRNA	23557933
C045950	propiconazole	propiconazole results in decreased expression of ROCK1 mRNA	19363144\|2127805
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ROCK1 mRNA	24780913
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of ROCK1 mRNA"	21152443
C428725	pyridaben	pyridaben results in increased expression of ROCK1 mRNA	22563483
D011794	Quercetin	Quercetin results in increased expression of ROCK1 protein	15221776\|2364574
C012526	quercitrin	quercitrin affects the expression of ROCK1 mRNA	25193878
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of ROCK1 mRNA	20970835
C059514	resveratrol	resveratrol results in decreased expression of ROCK1 mRNA	18089832
C059514	resveratrol	resveratrol results in decreased expression of ROCK1 protein	18089832
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of ROCK1 mRNA	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of ROCK1 mRNA	21795629
C025451	sodium bisulfide	sodium bisulfide results in increased activity of ROCK1 protein	23479079
D018038	Sodium Selenite	Sodium Selenite results in increased expression of ROCK1 mRNA	18175754
C471405	sorafenib	sorafenib results in decreased expression of ROCK1 mRNA	19338580
C471405	sorafenib	sorafenib results in decreased expression of ROCK1 protein	19338580
C471405	sorafenib	sorafenib results in increased expression of ROCK1 protein	19338580
D013311	Streptozocin	fasudil inhibits the reaction [Streptozocin results in increased activity of ROCK1 protein]	23376009
D013311	Streptozocin	fasudil inhibits the reaction [Streptozocin results in increased expression of ROCK1 mRNA]	22429817
D013311	Streptozocin	Streptozocin results in increased activity of ROCK1 protein	23376009
D013311	Streptozocin	Streptozocin results in increased expression of ROCK1 mRNA	22429817
D010042	Ouabain	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]	20661774
D010042	Ouabain	Ouabain results in increased cleavage of ROCK1 protein	20661774
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ROCK1 mRNA	26378955
D013739	Testosterone	Testosterone inhibits the reaction [Dietary Fats results in increased expression of ROCK1 mRNA]	22010203
D013739	Testosterone	Testosterone affects the expression of ROCK1 mRNA	22028410
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNA	18691609\|2157046
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of ROCK1 protein	24760326
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ROCK1 mRNA	25613284
C402769	tipifarnib	tipifarnib results in increased expression of ROCK1 mRNA	16403772
C011559	tributyltin	tributyltin results in increased expression of ROCK1 mRNA	26314263
C001899	triptolide	triptolide results in decreased expression of ROCK1 mRNA	26420756
C001899	triptolide	triptolide results in decreased expression of ROCK1 mRNA	27554044
C057693	troglitazone	troglitazone results in increased expression of ROCK1 mRNA	19140230
D014635	Valproic Acid	Valproic Acid results in decreased expression of ROCK1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ROCK1 gene	29154799
D002762	Cholecalciferol	Cholecalciferol results in increased expression of ROCK1 mRNA	17170073
C108830	Y 27632	Y 27632 results in decreased activity of ROCK1 protein	10686302
C108830	Y 27632	[Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein	16675616
C108830	Y 27632	ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]	14615541
C108830	Y 27632	Y 27632 results in decreased activity of ROCK1 protein	14615541\|1978275

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	TAS	8798490 10436159
GO:0004674	protein serine/threonine kinase activity	-	IDA	10652353 11018042 18573880 18694941 19036714
GO:0004674	protein serine/threonine kinase activity	-	NAS	27853422
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	10652353 14660612 17853893 20230755 21281639 22085929 25416956 25448675 27853422
GO:0005524	ATP binding	-	IEA	-
GO:0017049	GTP-Rho binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003383	apical constriction	-	IEA	-
GO:0006468	protein phosphorylation	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0006939	smooth muscle contraction	-	TAS	12778124
GO:0007159	leukocyte cell-cell adhesion	-	IDA	12082081
GO:0007165	signal transduction	-	TAS	10436159
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	IMP	25816133
GO:0007266	Rho protein signal transduction	-	IGI	27160703
GO:0010506	regulation of autophagy	-	TAS	27853422
GO:0010508	positive regulation of autophagy	-	IGI	27853422
GO:0010613	positive regulation of cardiac muscle hypertrophy	-	IMP	28679962
GO:0010628	positive regulation of gene expression	-	IMP	27853422 28679962
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0016525	negative regulation of angiogenesis	-	IMP	19181962
GO:0022614	membrane to membrane docking	-	IDA	12082081
GO:0030036	actin cytoskeleton organization	-	TAS	10436159
GO:0030155	regulation of cell adhesion	-	TAS	12778124
GO:0030866	cortical actin cytoskeleton organization	-	IGI	25816133
GO:0030866	cortical actin cytoskeleton organization	-	IMP	25816133
GO:0031175	neuron projection development	-	IGI	27160703
GO:0032060	bleb assembly	-	IEA	-
GO:0032091	negative regulation of protein binding	-	IDA	18573880
GO:0032956	regulation of actin cytoskeleton organization	-	IDA	25911094
GO:0032956	regulation of actin cytoskeleton organization	-	TAS	12778124
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	-	IGI	25816133
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	-	IMP	25816133
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043410	positive regulation of MAPK cascade	-	IMP	28679962
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	-
GO:0045616	regulation of keratinocyte differentiation	-	IMP	19997641
GO:0045664	regulation of neuron differentiation	-	IGI	27160703
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0050900	leukocyte migration	-	IDA	12082081
GO:0050901	leukocyte tethering or rolling	-	IDA	12082081
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	-	TAS	27853422
GO:0051451	myoblast migration	-	ISS	-
GO:0051492	regulation of stress fiber assembly	-	TAS	12778124
GO:0051893	regulation of focal adhesion assembly	-	TAS	12778124
GO:0051894	positive regulation of focal adhesion assembly	-	ISS	-
GO:0070168	negative regulation of biomineral tissue development	-	ISS	-
GO:0071559	response to transforming growth factor beta	-	ISS	-
GO:0072659	protein localization to plasma membrane	-	IGI	25816133
GO:0072659	protein localization to plasma membrane	-	IMP	25816133
GO:0110061	regulation of angiotensin-activated signaling pathway	-	IMP	28679962
GO:0140058	neuron projection arborization	-	IGI	27160703
GO:1900223	positive regulation of amyloid-beta clearance	-	IGI	27853422
GO:1900242	regulation of synaptic vesicle endocytosis	-	IGI	27160703
GO:1902003	regulation of amyloid-beta formation	-	TAS	27853422
GO:1902430	negative regulation of amyloid-beta formation	-	IMP	24305806 27853422
GO:1902992	negative regulation of amyloid precursor protein catabolic process	-	IMP	24305806 27853422
GO:1903140	regulation of establishment of endothelial barrier	-	IGI	25816133
GO:1903140	regulation of establishment of endothelial barrier	-	IMP	25816133
GO:1903347	negative regulation of bicellular tight junction assembly	-	IGI	25816133
GO:1905205	positive regulation of connective tissue replacement	-	IMP	28679962
GO:1990776	response to angiotensin	-	ISS	-
GO:2000114	regulation of establishment of cell polarity	-	TAS	20803696
GO:2000145	regulation of cell motility	-	TAS	12778124

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IEA	-
GO:0001726	ruffle	-	ISS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005814	centriole	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	ISS	-
GO:0005886	plasma membrane	-	ISS	-
GO:0010494	cytoplasmic stress granule	-	ISS	-
GO:0030027	lamellipodium	-	ISS	-
GO:0032059	bleb	-	IEA	-
GO:0034774	secretory granule lumen	-	TAS	-
GO:0106003	amyloid-beta complex	colocalizes_with	IDA	27853422

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04310	Wnt signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04360	Axon guidance
hsa04510	Focal adhesion
hsa04670	Leukocyte transendothelial migration
hsa04810	Regulation of actin cytoskeleton
hsa05130	Pathogenic Escherichia coli infection
hsa05131	Shigellosis

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-111465	Apoptotic cleavage of cellular proteins	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194315	Signaling by Rho GTPases	IEA
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-195258	RHO GTPase Effectors	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	IEA
R-HSA-3928663	EPHA-mediated growth cone collapse	IEA
R-HSA-400685	Sema4D in semaphorin signaling	TAS
R-HSA-400685	Sema4D in semaphorin signaling	IEA
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	TAS
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5627117	RHO GTPases Activate ROCKs	TAS
R-HSA-5627117	RHO GTPases Activate ROCKs	IEA
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-75153	Apoptotic execution phase	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25380619	ROCK1 as a novel prognostic marker in vulvar cancer. (2014 Nov 7)	Akagi EM	BMC Cancer
20139919	Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers. (2010 Apr)	Hidaka T	Hypertens Res